EO/EP copolymer membranes as reservoir in a transdermal therapeutic system for caffeine delivery: Modeling and simulation

Journal of Membrane Science

Volumn 241, Issue 2, 2004, Pages 297-304

  Mourgues, A ^a   Charmette, C ^a   Sanchez, J ^a   Marti Mestres, G ^b   Gramain, Ph ^a  

^a CNRS   (France)

^b UNIV MONTPELLIER   (France)

Author keywords

Caffeine; Elastomer membrane; EO EP copolymer; Human skin; Modeling; Transdermal therapeutic system

Indexed keywords

ABSORPTION; COPOLYMERS; DESORPTION; DRUG PRODUCTS; MASS TRANSFER; POLYETHYLENE OXIDES;

COPOLYMER MEMBRANES; TRANSDERMAL THERAPEUTIC SYSTEMS;

POLYMERIC MEMBRANES;

CAFFEINE; COPOLYMER; EPICHLOROHYDRIN; ETHYLENE OXIDE;

MEMBRANE;

ABSORPTION; ARTICLE; CROSS LINKING; DESORPTION; DIFFUSION; MEMBRANE TRANSPORT; MOLECULAR MODEL; PRIORITY JOURNAL; SIMULATION; SKIN; TRANSDERMAL DRUG ADMINISTRATION;

EID: 4043085644     PISSN: 03767388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.memsci.2004.05.021     Document Type: Article

References (21)

1. Boucaud A., Machet L., Arbeille B., Mavhet M.C., Sournac M., Mavon A., Patat F., Vaillant L. In vitro study of low-frequency ultrasound-enhanced transdermal of fentanyl and caffeine across human and hairless rat skin. Int. J. Pharm. 228:2001;69-77
2. Ouriemchi E.M., Vergnaud J.M. Processes of drug transfer with three different polymeric systems with transdermal drug delivery. Comput. Theor. Polym. Sci. 10:2000;391-401
3. Barry B.W. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci. 14:2001;101-114
4. Gore A.V., Chien Y.W. The nicotine transdermal system. Clin. Dermatol. 16:1998;599-615
5. Lien E.J., Tong G.L. Physicochemical properties and percutaneous absorption of drugs. J. Soc. Cosmet. Chem. 24:1973;371-384
6. Potts R.O., Guy R.H. Predicting skin permeability. Pharm. Res. 9:1992;663-669
7. Degim I.T., Pugh W.J., Hadgraft J. Skin permeability data: anomalous results. Int. J. Pharm. 170:1998;128-133
8. Roberts M.S., Pugh W.J., Hadgraft J. Epidermal permeability: penetrant structure relationships. 2. The effect of H-bonding groups in penetrants on their diffusion through the stratum corneum. Int. J. Pharm. 132:1996;23-32
9. Taft R.W., Abrahamet N.H., Doherty R.M., Kamlet M.J. The molecular properties governing solubilities of organic nonelectronlytes in water. Nature. 315:1985;384-386
10. Kamlet M.J., Abboud J.L., Abraham M.H., Taft R.W. Lineal solvation energy relationships. 23. A comprehensive collections of the solvatochromic parameters, π*, α and β, and some methods for simplifying the generalized solvatochromic equation. J. Org. Chem. 48:1983;2877-2887
11. Abraham M.H., Martins F., Mitchell R.C. Algorithms for skin permeability using hydrogen bond descriptions: the problem of steroids. J. Pharm. Pharmacol. 49:1997;858-865
12. Anderson B.D., Raykar P.V. Solute structure-permeability relationships in human stratum corneum. J. Invest. Dermatol. 93:1989;280-286
13. Tayar E., Tsai R.S., Testa B., Carrupt P.A., Hansch C., Leo A. Percutaneous penetration of drugs: a quantitative structure-permeability relationship study. J. Pharm. Sci. 80:1991;744-749
14. Ouriemchi E.M., Ghosh T.P., Vergnaud J.M. Transdermal drug transfer from a polymer device: study of the polymer and the process. Polym. Test. 19:2000;889-897
15. Sanchez J., Charmette C., Gramain P. Poly(ethylene oxide-co- epichlorohydrin) membranes for carbon dioxide separation. J. Membr. Sci. 205:2002;259-263
16. J. Sanchez, P. Gramain, Membranes pour la séparation sélective de gaz, CNRS Patents: FR 0011811, 15/09/2000, EP1322409, 02/07/2003, US 200330180425, 25/09/2003.
17. Cevc G., Blume G., Scätzlein A., Gebauer D., Paul A. The skin: a pathway for systemic treatment with patches and lipid-based agent carriers. Adv. Drug Deliv. Rev. 18:1996;349-378
18. M. Mokhtari, Matlab 5.2 & 5.3 et Simulink 2 & 3 pour étudiants et ingénieurs, Springer, Berlin, 2000.
19. R.H. Perry, H. Green, Chemical Engineers Handbook, McGraw-Hill, 1999, pp. 2-330.
20. Dias M., Farinha A., Faustino E., Hadgraft J., Pais J., Toscano C. Topical delivery of caffeine from some commercial formulations. Int. J. Pharm. 182:1999;41-47
21. Monti D., Giannelli R., Chetoni P., Burgalassi S. Comparison of the effect of ultrasound and of chemical enhancers on transdermal permeation of caffeine and morphine through hairless mouse skin in vitro. Int. J. Pharm. 229:2001;131-137