Pharmacokinetic/pharmacodynamic modelling of effects of dexamethasone and prednisolone in combination with endogenous cortisol on lymphocyte counts and systemic markers of bone turn over and inflammation in healthy and asthmatic men

European Journal of Clinical Pharmacology

Volumn 60, Issue 5, 2004, Pages 315-328

  Dubois, E F L ^a   Derks, M G M ^b   Schweitzer, D H ^a   Swinderman, A H ^b   Dekhuijzen, P N R ^c   Van Boxtel, C J ^b  

^a REINIER DE GRAAF HOSPITAL   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cortisol; Dexamethasone; Efficacy; Potency

Indexed keywords

DEXAMETHASONE; EOSINOPHIL CATIONIC PROTEIN; GLUCOCORTICOID; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROCORTISONE; OSTEOCALCIN; PREDNISOLONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENCY; HORMONE SYNTHESIS; HUMAN; LYMPHOCYTE COUNT; MALE; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL;

EID: 4043076220     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-004-0738-z     Document Type: Article

References (43)

1. Marble A, Selenkow HA, Rose LI, Dluhy RG, Williams GH (1980) Endocrine diseases. In: Avery GS (ed) Drug treatment, 2nd edn. Churchill Livingstone, Edinburgh and London, p 530
2. McKenzie AW, Stoghton RB (1962) Method for comparing percitaneous absorption of steroids. Arch Dermatol 86:608-610
3. Sommer A, Veraart J, Neumann M, Kessels A (1998) Evaluation of the vasoconstrictive effects of topical steroids Doppler-perfusion-imaging. Acta Derm Venereol 78:15-18
4. Noon JP, Evans CE, Haynes WG, Webb DJ, Walker BR (1996) A comparison of techniques to assess skin blanching following the topical application of glucocorticoids. Br J Dermatol 134:837-842
5. Langhoff E, Ladefoged J (1983) Relative immunosuppressive potency of various corticosteroids measured in vitro. Eur J Clin Pharmacol 25:459-462
6. Mullol J, Xaubet A, Lopez E, Roca-Ferrer J, Picado C (1995) Comparative study of the effects of different glucocorticosteroids on eosinophil survival primed by cultured epithelial cell supernatants obtained from nasal mucosa and nasal polyps. Thorax 50:270-274
7. Snijdewint FG, Kapsenberg ML, Wauben-Penris PJ, Bos JD (1995) Corticosteroids class dependently inhibit in vitro Th1-and Th2-type cytokine production. Immunopharmacology 29:93-101
8. Derks MGM, Dubois EFL, Koopmans RP, Boxtel van CJ (1999) Effect of hydrocortisone on plasma tyrosine concentration and lymphocyte counts in healthy volunteers. Clin Drug Invest 18:390-401
9. Ekenstam E, Stålenheim G, Hällgren R (1988) The acute effect of high dose corticosteroid treatment on serum osteocalcin. Metabolism 37:141-144
10. Godschalk MF, Downs RW (1988) Effect of short-term glucocorticoids on serum osteocalcin in healthy young men. J Bone Miner Res 3:113-115
11. Bijlsma JWJ, Lems WF, Gerrits MI, Jacobs JWG, van Vugt RM, van Rijn HJM (1995) Effect of high-dose corticosteroid pulse therapy on (markers of) bone formation and resorption in rheumatoid arthritis (abstract). Calcif Tissue Int 56:500
12. Gerrits MI, Lems WF, Bijlsma JWJ, Thijssen JHH, van Rijn HJM (1996) Botmetabolisme een overzicht van Klinischchemische markers. Ned Tijdschr Klin Chem 21:184-192
13. Khosla S, Kleerekoper M (1999) Biochemical markers of bone turnover. In: Favus MJ, Goldring SR, Christakos S (eds) Primer on the bone diseases and disorders of mineral metabolism 4th edn. Lippincott, Williams and Wilkins, Philadelphia, pp 128-134
14. Epstein S (1988) Serum and urinary markers of bone remodeling: assessment of bone turnover. Endocr Rev 9:437-449
15. Lian JB, Gundberg CM (1988) Osteocalcin: biochemical considerations and clinical applications. Clin Orthopaed Relat Res 226:267-291
16. Szulc P, Seeman E, Delmas PD (2000) Biochemical measurements of bone turnover in children and adolescents. Osteoporos Int 11:281-294
17. Wald J, Jusko W (1992) Corticosteroid pharmacodynamic modelling: osteocalcin suppression by prednisolone. Pharm Res 9:1096-1098
18. Nielsen H, Charles P, Moskilde L (1988) The effect of single oral doses of prednisolone in circadian rhythm of serum osteocalcin in normal subjects. J Clin Endocrinol Metab 67:1025-1030
19. Nielsen HK, Laurberg P, Brixen K, Mosekilde L (1991) Relationship between diurnal variations in serum osteocalcin, cortisol, parathyroid hormone, and ionized calcium in normal individuals. Acta Endocrinol 124:391-398
20. Nielsen HK, Brixen K, Kassem M, Charles P, Moskilde L (1992) Inhibition of the morning cortisol peak abolishes the expected morning decrease in serum osteocalcin in normal males: evidence of a controlling effect of serum cortisol on the circadian rhythm in serum osteocalcin. J Clin Endocrinol Metab 74:1410-1414
21. Heshmati HM, Riggs BL, Burritt MF, Mc Allister CA, Wollan PC, Khosla S (1998) Effects of the circadian variation in serum cortisol on markers of bone turnover and calcium homeostasis in normal postmenopausal women. J Clin Endocrinol Metab 83:751-756
22. Dubois EFL, Derks MGM, Zwinderman AH, Dekhuijzen PNR, van Boxtel CJ, Schweitzer DH (2003) Distinct actions of prednisolone and dexamethasone towards osteocalcin and eosinophilic cationic protein in assumed clinically equivalent doses: a study in healthy men. Eur J Clin Pharmacol 58:733-737
23. Denburg JA (1997) Effects of corticosteroids on basophils and mast cells. In: Schleimer RP, Busse WW, O'Byrne PM (eds) Lung biology in health and disease. Marcel Dekker, New York, pp 259-277
24. Wever AM, Wever Hess J, Hermans J (1997) The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma. Clin Exp Allergy 27:519-529
25. Karawajczyk M, Höglund M, Ericsson J, Venge P (1997) Administration of G-CSF to healthy subjects: the effects on eosinophil counts and mobilization of eosinophil granule proteins. Br J Haematol 96:259-265
26. van Boxtel CJ, Oosterhuis B (1992) Pharmacokinetic-pharmacodynamic modeling of corticosteroids. In: van Boxtel CJ, Holford NHG, Danhof M (eds) The in vivo study of drug action. Elsevier, Amsterdam, pp 357-377
27. Leuppi JD, Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, Chan HK, Woolcock AJ (2001) Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. Am J Respir Crit Care Med 163:406-412
28. Gibson PG, Wong BJ, Hepperle MJ, Kline PA, Girgis-Gabardo A, Guyatt G, Dolovich J, Denburg JA, Ramsdale EH, Hargreave FE (1992) A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid. Clin Exp Allergy 22:525-532
29. Rose JQ, Jusko WJ (1979) Corticosteroid analysis in biological fluids by high-performance liquid chromatography. J Chromatogr 162:273-280
30. Masters PW, Jones RG, Purves DA, Cooper EH, Cooney JM (1994) Commercial essays for serum osteocalcin give clinically discordant results. Clin Chem 40:358-363
31. Anonymous (1986) Micromath, Inc., Scientist, ver 2.0. Salt MicroMath Scientific Software, Lake City
32. Gibaldi M, Perrier D (1975) Pharmacokinetics. Marcel Dekker, New York
33. Braat MC, Oosterhuis B, Koopmans RP, Meewis JM, van Boxtel CJ (1992) Kinetic-dynamic modeling of lymphocytopenia induced by the combined action of dexamethasone and hydrocortisone in humans, after inhalation and intravenous administration of dexamethasone. J Pharmacol Exp Ther 262:509-515
34. Holford NH, Sheiner LB (1982) Kinetics of pharmacologic response. Pharmacol Ther 16:143-166
35. Holford NH, Sheiner LB (1981) Pharmacokinetic and pharmacodynamic modeling in vivo. CRC Crit Rev Bioeng 5:273-322
36. Koopmans RP, Braat MC, Oosterhuis B, van Boxtel CJ (1992) Time-dependent effects of dexamethasone administration on the suppression of plasma hydrocortisone, assessed with a pharmacokinetic model. J Pharmacol Exp Ther 262:503-508
37. Aris RM, Stephens AR, Ontjes DA, Denene Blackwood A, Lark RK, Hensler MB, Neuringer IP, Lester GE (2000) Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am J Respir Crit Care Med 162:1674-1678
38. Cortet B, Guyot MH, Solau E, Pigny P, Dumoulin F, Flipo RM, Marchandise X, Delcambre B (2000) Factors influencing bone loss in rheumatoid arthritis: a longitudinal study. Clin Exp Rheumatol 18:683-690
39. Oosterhuis B, ten Berge RJ, Sauerwein HP, Endert E, Schellekens PT, van Boxtel CJ (1984) Pharmacokinetic-pharmacodynamic modeling of prednisolone-induced lymphocytopenia in man. J Pharmacol Exp Ther 229:539-546
40. Futijaka M, Kawaguchi H, Kato Y, Sakura N, Ueda K, Abe Y (2001) Significance of eosinophil cationic protein/eosinophil count ratio in asthmatic patients: its relationship to disease severity. Ann Allergy Immunol 86:323-329
41. Wark PA, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG (2002) Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 19:68-75
42. Malo JL, Cartier A, Ghezzo H, Mark S, Brown J, Laviolette M, Boulet LP (1999) Skin bruising, adrenal function and markers of bone metabolism in asthmatics using inhaled beclomethasone and fluticasone. Eur Respir J 13:993-998
43. Lipworth BJ (1999) Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Arch Intern Med 159:941-55