Effect of hydrocortisone on plasma tyrosine concentration and lymphocyte counts in healthy volunteers

Clinical Drug Investigation

Volumn 18, Issue 5, 1999, Pages 391-401

  Derks, M G M ^a   Dubois, E F L ^b   Koopmans, R P ^a   Van Boxtel, C J ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b REINIER DE GRAAF HOSPITAL   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; HYDROCORTISONE; TYROSINE; TYROSINE AMINOTRANSFERASE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; ENZYME INDUCTION; HUMAN; HUMAN EXPERIMENT; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032749358     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199918050-00006     Document Type: Article

References (31)

1. Rivlin RS, Kenneth LM. Cortisone-provoked depression of plasma Tyrosine concentration: relation to enzyme induction in man. J Clin Invest 1965; 44 (10): 1690-8
2. Milad MA, Ludwig EA, Anne S, et al. Pharmacodynamic model for joint exogenous and endogenous corticosteroid suppression of lymphocyte trafficking. J Pharmacokinet Biopharm 1994; 22 (6): 469-80
3. Xu ZX, Sun YN, DuBois DC, et al. Third-generation model for corticosteroid pharmacodynamics: roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver. J Pharmacokinet Biopharm 1995; 23: 163-81
4. Shimizu H, Taniguchi K, Sugiyama M, et al. Rapid enzymatic analysis of plasma for tyrosine. Clin Chem 1990; 36: 32-5
5. Munro HN, editor. Mammalian protein metabolism. New York: Academic Press, 1969
6. Nichols AI, Boudinot FD, Jusko WJ. Second generation model for prednisolone pharmacodynamics in the rat. J Pharmacokinet Biopharm 1989; 17: 209-27
7. Nichols AI, D'Ambrosio R, Pyszczynski NA, et al. Pharmacokinetics and pharmacodynamics of prednisolone in obese rats. J Pharmacol Exp Ther 1989; 250: 963-70
8. Oosterhuis B, Ten Berge I, Schellekens PT, et al. Concentration dependent effects of prednisolone on lymphocyte subsets and mixed lymphocyte culture in humans. J Pharmacol Exp Ther 1987; 243 (2): 716-22
9. Fernstrom JD, Wurtman RJ, Hammarstrom-Wiklund B, et al. Diurnal variations in plasma concentrations of tryptophan, tryosine, and other neutral amino acids: effect of dietary protein intake. Am J Clin Nutr 1979; 32: 1912-22
10. Akbulat H, Icli F, Buyukcelik, A, et al. The role of granulocyte-macrophage-colony stimulating factor, cortisol, and melatonin in the regulation of the circadian rhythms of peripheral blood cells in healthy volunteers and patients with breast cancer. J Pin Res 1999; 26: 1-8
11. Barnes PJ, Adcock IM. Steroid resistance in asthma. Q J Med 1995; 88: 455-68
12. Rohatagi S, Tauber U, Richter K, et al. Pharmacokinetic/pharmacodynamic modeling of cortisol suppression after oral administration of fluocortolone. J Clin Pharmacol 1996; 36: 311-4
13. van Boxtel CJ, Oosterhuis B. Pharmacokinetic-pharmacodynamic modelling of glucocorticosteroid action. In: van Boxtel CJ, Holford NHG, Danhof M, editors. The in vivo study of drug action. Amsterdam: Elsevier Science Publisher B.V., 1992; 357-75
14. Oosterhuis B, Ten Berge I, Schellekens PT, et al. Prednisolone concentration-effect relations in humans and the influence of plasma hydrocortisone. J Pharmacol Exp Ther 1986; 239 (3): 919-26
15. Jusko WJ, Ko HC. Physiologic indirect response models characterize diverse types of pharmacodynamic effects. Clin Pharmacol Ther 1994; 56: 406-19
16. Le YY, Xu RB. The molecular mechanism of the action of the pharmacological doses of glucocorticoids. Studies on the low-affinity glucocorticoid receptor. Receptor 1995; 5; 63-9
17. Boudinot FD, D'Ambrosio R, Jusko WJ. Receptor-mediated pharmacodynamics of prednisolone in the rat. J Pharmacokinet Biopharm 1986; 14 (5): 469-93
18. Dayneka NL, Garg V, Jusko WJ. Comparison of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharm 1993; 21 (4): 457-78
19. Rose JQ, Jusko WJ. Corticosteroid analysis in biological fluids by high-performance liquid chromatography. J Chromatogr 1979; 162 (3): 273-80
20. Oosterhuis B, Ten Berge, Sauerwein HP, et al. Pharmacokinetic-pharmacodynamic modeling of prednisolone-induced lymphocytopenia in man. J Pharmacol Exp Ther 1984; 229 (2): 539-46
21. Edwards DJ, Sorisio D, Knopf S, et al. Assay for L-p-tyrosine in plasma and brain by column liquid chromatography with electrochemical detection using m-tyrosine as the internal standard. J Chromatogr 1986; 383 (1): 142-7
22. Gibaldi M, Perrier D. Pharmacokinetics. New York: Marcel Dekker Inc., 1975
23. Koopmans RP, Braat MC, Oosterhuis B, et al. Time-dependent effects of dexamethasone administration on the suppression of plasma hydrocortisone, assessed with a pharmacokinetic model. J Pharmacol Exp Ther 1992; 262: 503-8
24. Scientist, MicroMath i. 2.0. Salt Lake City: MicroMath Scientific Software, 1986
25. Lundin PM, Hedman I.A. Influence of corticosteroids on lymphocyte recirculalion. Lymphology 1978; 11 (4): 216-21
26. Fisher LE, Ludwig EA, Jusko WJ. Pharmacoimmunodynamics of methylprednisolone: trafficking of helper T lymphocytes. J Pharmacokinet Biopharm 1992; 20 (4): 319-31
27. DuBois DC, Xu ZX, McKay L, et al. Differential dynamics of receptor down-regulation and tyrosine aminotransferase induction following glucocorticoid treatment. J Steroid Biochem Mol Biol 1995; 54 (5-6): 237-43
28. Haughey DB, Jusko WJ. Receptor-mediated methylprednisolone pharmacodynamics in rats: steroid-induced receptor down-regulation. J Pharmacokinet Biopharm 1992; 20 (4): 333-55
29. Jusko WJ. Receptor-mediated pharmacodynamics of corticosteroids. Prog Clin Biol Res 1994; 387; 261-70
30. Piruzian LA, Rass IT. The safety problem and a physiological strategy for using glucocorticoid hormones [in Russian]. Izv Akad Nauk SSSR Biol 1991 Sep-Oct; (5): 735-43
31. Agharanya JC, Alonso R, Wurtman RJ. Changes in catecholamine excretion after short-term tyrosine ingestion in normally fed human subjects. Am J Clin Nutrition 1981; 34: 82-7