FK506 to prevent lung injury after hindlimb ischemia and reperfusion in a rat model? An electron microscopic study

Surgery Today

Volumn 34, Issue 8, 2004, Pages 678-684

  Akgun, Serdar ^a,d   Tekeli, Atike ^a   Isbir, Selim C ^a   Civelek, Ali ^a   Koray, Ak ^a   Sirvanci, Serap ^a   Arbak, Serap ^a   Yaylim, Ilhan ^b   Arsan, Sinan ^c  

^a MARMARA UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c MALTEPE UNIVERSITY   (Turkey)

^d MUTFV Academic Hospital   (Turkey)

Author keywords

Extremities; Ischemia reperfusion injury; Lung

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTRON MICROSCOPY; HINDLIMB; HISTOPATHOLOGY; ISCHEMIA; LUNG INJURY; MALE; MICROSCOPY; NONHUMAN; RAT; REPERFUSION; REPERFUSION INJURY;

EID: 4043065059     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00595-004-2799-0     Document Type: Article

References (23)

1. Prem JT, Eppinger M, Lemmon G, Miller S, Nolan D, Peoples J. The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model. Am J Surg 1999;178:147-50.
2. Klausner JM, Paterson IS, Valeri R, Hechtman HB. Limb ischemia induced increase in permeability is mediated by leukocytes and leukotrienes. Ann Surg 1988;208:755-60.
3. Klausner JM, Paterson IS, Kozbik L, Valeri R, Shepro D, Hechtman HB. Oxygen free radicals mediate ischemia-induced lung injury. Surgery 1989;105:192-9.
4. Bengisun U, Koksoy C, Bengisun JS, Bayraktaroglu G, Camur A, Aras N. Ischemia and reperfusion injury: prevention of pulmonary hypertension and leukosequestration following lower limb ischemia. Prostagland Leukotrienes Essent Fatty Acids 1997;56:117-20.
5. Fantini GA, Conte MS. Pulmonary failure following lower torso ischemia: clinical evidence for remote effect of reperfusion injury. Am J Surg 1995;61:316-9.
6. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury: modulating effects of FK506 and cyclosporine. Transplantation 1993;55:1265-72.
7. Dhar DK, Nagasue N, Kimoto T, Uchida M, Takemoto Y, Nakamura T. The salutary effect of FK506 in ischemia reperfusion injury of the canine liver. Transplantation 1992;54:583-8.
8. Kubes P, Hunter J, Granger DN. Effects of cyclosporine A and FK506 on ischemia reperfusion injury induced neutrophil infiltration in the cat. Dig Dis Sci 1991;36:1469-72.
9. Sakr M, Zetti G, McClain C, Gavaler J, Nalesnik M, Todo S, et al. The protective effect of FK506 pretreatment against renal ischemia reperfusion injury in rats. Transplantation 1992;53:987-91.
10. Nishinaka Y, Sugiyama S, Yokota M, Saito H, Ozawa T. Protective effect of FK506 on ischemia reperfusion induced myocardial damage in canine heart. J Cardiovasc Pharmacol 1993;21:448-54.
11. Cetinkale O, Bilgic L, Bolayirli M, Sengul R, Ayan F, Burcak G. Involvement of neutrophils in ischemia reperfusion injury of inguinal island skin flaps in rats. Plast Reconstr Surg 1998;102:153-60.
12. Shin MS, Angel MF, Im MJ, Manson PN. Effects of 21-aminosteroid U74389F on skin-flap survival after secondary ischemia. Plast Reconst Surg 1994;94:661-6.
13. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265-75.
14. Ellman GL. Tissue sulphydryl groups. Arch Biochem Biophys 1959;82:70-7.
15. Ozveri ES, Bozkurt A, Haklar G, Cetinel S, Arbak S, Yegen C, et al. Estrogens ameliorate remote organ inflammation induced by burn injury in rats. Infl Res 2001;50:585-91.
16. Sakon M, Ariyoshi H, Umehita K, Monden M. Ischemia-reperfusion injury of the liver with special reference to calcium-dependent mechanisms. Surg Today 2002;32:1-12.
17. Lee C, Kerrigan CL, Tellado JM. Altered neutrophil function following reperfusion of an ischemic myocutaneous flap. Plast Reconstr Surg 1992;89:916-23.
18. Cetinkale O, Bilgic L, Ayan F, Kandilci A. Neutrophil mediated injury ischemic skin flaps: amelioration of ischemic injury by cyclosporine in the rat. Ann Plast Surg 1996;37:66-74.
19. Messent M, Griffiths MJD, Evans TW. Pulmonary vascular reactivity and ischemia reperfusion injury in the rat. Clin Sci 1993;85:71-5.
20. Blaisdell FW. The reperfusion syndrome. Microcirc Endothelium Lymphatics 1989;5:127-41.
21. Reilly PM, Schiller HJ, Bulkley GB. Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. Am J Surg 1991;161:488-503.
22. Cetinkale O, Konukoglu D, Senel O, Kemerli GD, Yazar S. Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury. Burns 1999;25:105-12.
23. Kawano K, Kim YI, Goto S, Ono M, Kobayashi M. A protective effect of FK506 in ischemically injured rat livers. Transplantation 1991;52:143-5.