Marginal maternal vitamin B 12 status increases the risk of offspring with spina bifida

American Journal of Obstetrics and Gynecology

Volumn 191, Issue 1, 2004, Pages 11-17

  Groenen, Pascal M W ^a   Van Rooij, Iris A L M ^a   Peer, Petronella G M ^a   Gooskens, Rob H ^a   Zielhuis, Gerhard A ^a   Steegers Theunissen, Régine P M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

B vitamin; Neural tube defect; Nutrition

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

AGE; ARTICLE; BLOOD SAMPLING; CONFIDENCE INTERVAL; ERYTHROCYTE; HUMAN; MOTHER; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; RISK; SERUM; SPINA BIFIDA;

CASE-CONTROL STUDIES; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; INFANT; MALE; PREGNANCY; RISK ASSESSMENT; RISK FACTORS; SPINAL DYSRAPHISM; VITAMIN B 12; VITAMIN B 6;

EID: 4043060851     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2003.12.032     Document Type: Article

References (26)

1. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. 338:1991;131-137
2. Berry R.J., Li Z., Erickson J.D., Li S., Moore C.A., Wang H., et al. Prevention of neural-tube defects with folic acid in China. N Engl J Med. 341:1999;1485-1490
3. Czeizel A.E., Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 327:1992;1832-1835
4. Steegers-Theunissen R.P.M., Boers G.H., Trijbels F.J., Eskes T.K.A.B. Neural-tube defects and derangement of homocysteine metabolism. N Engl J Med. 324:1991;199-200
5. Steegers-Theunissen R.P.M., Boers G.H., Trijbels J.F., Finkelstein J.D., Blom H.J., Thomas C.M. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism. 43:1994;1475-1480
6. Rosenquist T.H., Ratashak S.A., Selhub J. Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid. Proc Natl Acad Sci U S A. 93:1996;15227-15232
7. Kirke P.N., Molloy A.M., Daly L.E., Burke H., Weir D.G., Scott J.M. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med. 86:1993;703-708
8. Schorah C.J., Smithells R.W., Scott J. Vitamin B12 and anencephaly [Letter]. Lancet. 1:1980;880
9. Smithells R.W., Sheppard S., Schorah C.J. Vitamin deficiencies and neural tube defects. Arch Dis Child. 51:1976;944-950
10. Carmel R., Melnyk S., James S.J. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism. Blood. 101:2003;3302-3308
11. Scott J.M., Weir D.G. The methyl folate trap: a physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet. 2:1981;337-340
12. Afman L.A., van der Put N.M., Thomas C.M., Trijbels J.M., Blom H.J. Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects. QJM. 94:2001;159-166
13. Groenen P.M., Peer P.G.M., Wevers R.A., Swinkels D.W., Franke B., Mariman E.C.M., et al. Maternal myo-inositol, glucose and zinc status is associated with the risk of spina bifida offspring. Am J Obstet Gynecol. 189:2003;1713-1719
14. Van Rooij I.A.L.M., Vermeij-Keers C., Kluijtmans L.A., Ocke M.C., Zielhuis G.A., Goorhuis-Brouwer S.M., et al. Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate? Am J Epidemiol. 157:2003;583-591
15. van Rooij I.A.L.M., Swinkels D., Blom H.J., Merkus H.M.W.M., Steegers-Theunissen R.P.M. Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol. 189:2003;1155-1160
16. Kuemmerle S.C., Boltinghouse G.L., Delby S.M., Lane T.L., Simondsen R.P. Automated assay of vitamin B-12 by the Abbott IMx analyzer. Clin Chem. 38:1992;2073-2077
17. Molloy A.M., Scott J.M. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol. 281:1997;43-53
18. Schrijver J., Speek A.J., Schreurs W.H. Semi-automated fluorometric determination of pyridoxal-5′-phosphate (vitamin B6) in whole blood by high-performance liquid chromatography (HPLC). Int J Vitam Nutr Res. 51:1981;216-222
19. te Poele-Pothoff M.T., van den B.M., Franken D.G., Boers G.H., Jakobs C., de Kroon I.F., et al. Three different methods for the determination of total homocysteine in plasma. Ann Clin Biochem. 32:(suppl):1995;218-220
20. van der Put N.M., Thomas C.M., Eskes T.K., Trijbels F.J., Steegers-Theunissen R.P., Mariman E.C., et al. Altered folate and vitamin B12 metabolism in families with spina bifida offspring. QJM. 90:1997;505-510
21. Mills J.L., McPartlin J.M., Kirke P.N., Lee Y.J., Conley M.R., Weir D.G., et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet. 345:1995;149-151
22. Brouwer I.A., van Dusseldorp M., Thomas C.M., van der Put N.M., Gaytant M.A., Eskes T.K., et al. Homocysteine metabolism and effects of folic acid supplementation in patients affected with spina bifida. Neuropediatrics. 31:2000;298-302
23. Botto L.D., Moore C.A., Khoury M.J., Erickson J.D. Neural-tube defects. N Engl J Med. 341:1999;1509-1519
24. Steegers-Theunissen R.P.M., Steegers E.A.P. Nutrient-gene interactions in early pregnancy: a vascular hypothesis. Eur J Obstet Gynecol Reprod Biol. 106:2003;115-117
25. Minet J.C., Bisse E., Aebischer C.P., Beil A., Wieland H., Lutschg J. Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates. Am J Clin Nutr. 72:2000;751-757
26. Gallagher P.G., Ehrenkranz R.A. Nutritional anemias in infancy. Clin Perinatol. 22:1995;671-692