On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations

International Journal of Cancer

Volumn 122, Issue 8, 2008, Pages 1916-1917

  Simon, Richard ^a   Zhang, Xinan ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

Breast cancer; Oncogenesis; Stochastic model

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ALLELE; ARTICLE; BREAST CARCINOGENESIS; BREAST TUMOR; CANCER CELL; CELL CLONE; CELL PROLIFERATION; GENE MUTATION; GENOMIC INSTABILITY; GERM LINE; MATHEMATICAL MODEL; MUTATIONAL ANALYSIS; ONCOGENE; PRIORITY JOURNAL; RETINOBLASTOMA; ADULT; AGED; DISEASE COURSE; FEMALE; GENE FREQUENCY; GENETICS; HETEROZYGOTE; HUMAN; INCIDENCE; MATHEMATICAL COMPUTING; MIDDLE AGED; MUTATION; STATISTICAL MODEL; STATISTICS; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BREAST NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE FREQUENCY; GENES, BRCA1; GENES, BRCA2; GERM-LINE MUTATION; HETEROZYGOTE; HUMANS; INCIDENCE; MATHEMATICAL COMPUTING; MIDDLE AGED; MODELS, STATISTICAL; STOCHASTIC PROCESSES;

EID: 40349108598     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23323     Document Type: Article

References (13)

1. Struewing J, Hartge P, Wacholder S, Baker S, Berlin M, McAdams M, Timmerman M, Brody L, Tucker M. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Asheennazi Jews. New Engl J Med 1997;336:1401-8.
2. Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS. Stem cells in normal breast development and breast cancer. Cell Prolif 2003;36:59-72.
3. Stingl J, Eirew P, Ricketson I, Shackelton M, Vaillant F, Choi D, Li H, Eaves C. Purification and unique properties of mammary epithelial stem cells. Nature 2006;439:993-7.
4. Zhang X, Simon R. Estimating the number of rate-limiting genomic changes for human breast cancer. Breast Cancer Res Treat 2005;91:121-4.
5. Osorio A, Hoya MDL, Rodriguez-Lopez R, Martinez-Ramirez A, Granizo J, Esteller M, Rivas C, Caldes T, Benitez J. Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer. Int J Cancer 2002;99:305-9.
6. Staff S, Nupponen N, Borg A, Isola J, Tanner M. Multiple copies of mutant BRCA1 and BRCA2 alleles in breast tumors from germ-line mutation carriers. Genes Chromosomes Cancer 2000;28:432-42.
7. Knudson A. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci 1971;68:820-3.
8. Kumar S, Subramanian S. Mutation rates in mammalian genomes. Proc Natl Acad Sci 2002;99:803-8.
9. Narod S, Foulkes W. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 2004;4:665-76.
10. Benezra M, Chevallier N, Morrison D, MacLachlan T, El-Deiry W, Licht J. BRCA1 augments transcription of the NF-κB transcription factor by binding to the Rel domain of the p65/RelA subunit. J Biol Chem 2003;278:26333-41.
11. Kinzler K, Vogelstein B. Gatekeepers and caretakers. Nature 1997;386:761-3.
12. Tong D, Kucera E, Schuster E, Schmutzler R, Swoboda H, Reinthaller A, Leodolter S, zeillinger R. Loss of heterozygosity (LOH) at p53 is correlated with LOH at BRCA1 and BRCA2 in various human malignant tumors. Int J Cancer 2000;88:319-22.
13. Xu X, Wagner K, Larson D, Weaver Z, Li C, Ried T, Henninghausen L, Wynshaw-Boris A, Deng C. Conditional mutation of BRCA1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation. Nature Genet 1999;22:37-43.