-
1
-
-
7744240083
-
Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women
-
Rademeyer C, van Harmelen JH, Ramjee G, et al. Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women. AIDS 2004; 18:2096-2098.
-
(2004)
AIDS
, vol.18
, pp. 2096-2098
-
-
Rademeyer, C.1
van Harmelen, J.H.2
Ramjee, G.3
-
2
-
-
33646858570
-
-
Sagar M, Kirkegaard E, Lavreys L, Overbaugh J. Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses 2006; 22:430-437.
-
Sagar M, Kirkegaard E, Lavreys L, Overbaugh J. Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses 2006; 22:430-437.
-
-
-
-
3
-
-
36348979223
-
Biological mechanisms of vertical human immunodeficiency virus (HIV-1) transmission
-
In press
-
Lehman DA, Farquhar C. Biological mechanisms of vertical human immunodeficiency virus (HIV-1) transmission. Rev Med Virol 2007; In press.
-
(2007)
Rev Med Virol
-
-
Lehman, D.A.1
Farquhar, C.2
-
4
-
-
0031036514
-
Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes
-
Contag CH, Ehrnst A, Duda J, et al. Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes. J Virol 1997; 71:1292-1300.
-
(1997)
J Virol
, vol.71
, pp. 1292-1300
-
-
Contag, C.H.1
Ehrnst, A.2
Duda, J.3
-
5
-
-
0035121355
-
Perinatal transmission of major, minor, and multiple maternal human immunodeficiency virus type 1 variants in utero and intrapartum
-
Dickover RE, Garratty EM, Plaeger S, Bryson YJ. Perinatal transmission of major, minor, and multiple maternal human immunodeficiency virus type 1 variants in utero and intrapartum. J Virol 2001; 75:2194-2203.
-
(2001)
J Virol
, vol.75
, pp. 2194-2203
-
-
Dickover, R.E.1
Garratty, E.M.2
Plaeger, S.3
Bryson, Y.J.4
-
6
-
-
0026551082
-
Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants
-
Wolinsky SM, Wike CM, Korber BT, et al. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants. Science 1992; 255:1134-1137.
-
(1992)
Science
, vol.255
, pp. 1134-1137
-
-
Wolinsky, S.M.1
Wike, C.M.2
Korber, B.T.3
-
7
-
-
0027457362
-
Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers
-
Scarlatti G, Leitner T, Halapi E, et al. Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers. Proc Natl Acad Sci USA 1993; 90:1721-1725.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1721-1725
-
-
Scarlatti, G.1
Leitner, T.2
Halapi, E.3
-
8
-
-
0028935432
-
Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child
-
Mulder-Kampinga GA, Simonon A, Kuiken CL, et al. Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child. J Virol 1995; 69:2285-2296.
-
(1995)
J Virol
, vol.69
, pp. 2285-2296
-
-
Mulder-Kampinga, G.A.1
Simonon, A.2
Kuiken, C.L.3
-
9
-
-
0027176286
-
Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo
-
Lamers SL, Sleasman JW, She JX, et al. Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo. J Virol 1993; 67:3951-3960.
-
(1993)
J Virol
, vol.67
, pp. 3951-3960
-
-
Lamers, S.L.1
Sleasman, J.W.2
She, J.X.3
-
10
-
-
0028854679
-
Genetic analysis of human immunodeficiency virus type 1 envelope V3 region isolates from mothers and infants after perinatal transmission
-
Ahmad N, Baroudy BM, Baker RC, Chappey C. Genetic analysis of human immunodeficiency virus type 1 envelope V3 region isolates from mothers and infants after perinatal transmission. J Virol 1995; 69:1001-1012.
-
(1995)
J Virol
, vol.69
, pp. 1001-1012
-
-
Ahmad, N.1
Baroudy, B.M.2
Baker, R.C.3
Chappey, C.4
-
11
-
-
30344485709
-
-
Wu X, Parast AB, Richardson BA, et al. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol 2006; 80:835-844. This study evaluated the susceptibility of individual env genes from mother and infant to neutralization by antibody in maternal plasma using a pseudovirus assay. The authors demonstrated that infant viruses are among the more resistant to maternal neutralizing antibody, and that fewer glycosylation sites in gp120 accompany this phenotype. Importantly, the results suggest multiple levels of selection during MTC transmission.
-
Wu X, Parast AB, Richardson BA, et al. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J Virol 2006; 80:835-844. This study evaluated the susceptibility of individual env genes from mother and infant to neutralization by antibody in maternal plasma using a pseudovirus assay. The authors demonstrated that infant viruses are among the more resistant to maternal neutralizing antibody, and that fewer glycosylation sites in gp120 accompany this phenotype. Importantly, the results suggest multiple levels of selection during MTC transmission.
-
-
-
-
12
-
-
33947600590
-
Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding
-
Rainwater SM, Wu X, Nduati R, et al. Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding. Curr HIV Res 2007; 5:189-197.
-
(2007)
Curr HIV Res
, vol.5
, pp. 189-197
-
-
Rainwater, S.M.1
Wu, X.2
Nduati, R.3
-
13
-
-
33745234845
-
Role of maternal autologous neutralizing antibody in selective perinatal transmission of human immunodeficiency virus type 1 escape variants
-
This study demonstrated both phenotypically and genetically that infant viruses are resistant to maternal neutralizing antibody, and described a potential protective effect for maternal neutralizing antibody in preventing in utero transmission
-
Dickover R, Garratty E, Yusim K, et al. Role of maternal autologous neutralizing antibody in selective perinatal transmission of human immunodeficiency virus type 1 escape variants. J Virol 2006; 80:6525-6533. This study demonstrated both phenotypically and genetically that infant viruses are resistant to maternal neutralizing antibody, and described a potential protective effect for maternal neutralizing antibody in preventing in utero transmission.
-
(2006)
J Virol
, vol.80
, pp. 6525-6533
-
-
Dickover, R.1
Garratty, E.2
Yusim, K.3
-
14
-
-
33750969378
-
Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease
-
Zhang H, Hoffmann F, He J, et al. Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease. Retrovirology 2006; 3:73.
-
(2006)
Retrovirology
, vol.3
, pp. 73
-
-
Zhang, H.1
Hoffmann, F.2
He, J.3
-
15
-
-
0037369116
-
Diversity of the human immunodeficiency virus type 1 (HIV-1) env sequence after vertical transmission in mother-child pairs infected with HIV-1 subtype A
-
Verhofstede C, Demecheleer E, De Cabooter N, et al. Diversity of the human immunodeficiency virus type 1 (HIV-1) env sequence after vertical transmission in mother-child pairs infected with HIV-1 subtype A. J Virol 2003; 77:3050-3057.
-
(2003)
J Virol
, vol.77
, pp. 3050-3057
-
-
Verhofstede, C.1
Demecheleer, E.2
De Cabooter, N.3
-
16
-
-
0003462242
-
-
UNAIDS-WHO, Geneva: Joint United Nations Programme on HIV/AIDS and World Health Organization;
-
UNAIDS-WHO. Report on the global AIDS epidemic, Geneva: Joint United Nations Programme on HIV/AIDS and World Health Organization; 2006.
-
(2006)
Report on the global AIDS epidemic
-
-
-
17
-
-
23244434512
-
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies
-
Li M, Gao F, Mascola JR, et al. Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. J Virol 2005; 79:10108-10125.
-
(2005)
J Virol
, vol.79
, pp. 10108-10125
-
-
Li, M.1
Gao, F.2
Mascola, J.R.3
-
18
-
-
33751224478
-
-
Li M, Salazar-Gonzalez JF, Derdeyn CA, et al. Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in southern Africa. J Virol 2006; 80:11776-11790. In this study, a well-characterized panel of subtype C Envs from acute/early infection was generated for use in evaluating vaccine reagents. A comparison between the characteristics of subtype B and C Envs from acute/early infection provide more evidence for subtype-specific differences during the transmission or establishment of infection.
-
Li M, Salazar-Gonzalez JF, Derdeyn CA, et al. Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in southern Africa. J Virol 2006; 80:11776-11790. In this study, a well-characterized panel of subtype C Envs from acute/early infection was generated for use in evaluating vaccine reagents. A comparison between the characteristics of subtype B and C Envs from acute/early infection provide more evidence for subtype-specific differences during the transmission or establishment of infection.
-
-
-
-
19
-
-
12144289425
-
Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission
-
Derdeyn CA, Decker JM, Bibollet-Ruche F, et al. Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission. Science 2004; 303:2019-2022.
-
(2004)
Science
, vol.303
, pp. 2019-2022
-
-
Derdeyn, C.A.1
Decker, J.M.2
Bibollet-Ruche, F.3
-
20
-
-
4644300726
-
Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers
-
Grobler J, Gray CM, Rademeyer C, et al. Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers. J Infect Dis 2004; 190:1355-1359.
-
(2004)
J Infect Dis
, vol.190
, pp. 1355-1359
-
-
Grobler, J.1
Gray, C.M.2
Rademeyer, C.3
-
21
-
-
18144429071
-
Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B
-
Frost SD, Liu Y, Pond SL, et al. Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B. J Virol 2005; 79:6523-6527.
-
(2005)
J Virol
, vol.79
, pp. 6523-6527
-
-
Frost, S.D.1
Liu, Y.2
Pond, S.L.3
-
22
-
-
33646751914
-
-
Li B, Decker JM, Johnson RW, et al. Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1. J Virol 2006; 80:5211-5218. This study directly compared autologous neutralizing antibody responses in early subtype B and C infection using a pseudovirus assay, and demonstrated that the neutralizing antibody titers in subtype C are more potent than in subtype B infection and are associated with compact Envs in the subtype C cohort.
-
Li B, Decker JM, Johnson RW, et al. Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1. J Virol 2006; 80:5211-5218. This study directly compared autologous neutralizing antibody responses in early subtype B and C infection using a pseudovirus assay, and demonstrated that the neutralizing antibody titers in subtype C are more potent than in subtype B infection and are associated with compact Envs in the subtype C cohort.
-
-
-
-
23
-
-
34147180438
-
HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry
-
Blish CA, Nedellec R, Mandaliya K, et al. HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry. AIDS 2007; 21:693-702.
-
(2007)
AIDS
, vol.21
, pp. 693-702
-
-
Blish, C.A.1
Nedellec, R.2
Mandaliya, K.3
-
24
-
-
0033978489
-
Gender differences in HIV-1 diversity at time of infection
-
Long EM, Martin HL Jr, Kreiss JK, et al. Gender differences in HIV-1 diversity at time of infection. Nat Med 2000; 6:71-75.
-
(2000)
Nat Med
, vol.6
, pp. 71-75
-
-
Long, E.M.1
Martin Jr, H.L.2
Kreiss, J.K.3
-
25
-
-
2942665473
-
Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes
-
Sagar M, Kirkegaard E, Long EM, et al. Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes. J Virol 2004; 78:7279-7283.
-
(2004)
J Virol
, vol.78
, pp. 7279-7283
-
-
Sagar, M.1
Kirkegaard, E.2
Long, E.M.3
-
26
-
-
4644296727
-
Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1
-
Ritola K, Pilcher CD, Fiscus SA, et al. Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1. J Virol 2004; 78:11208-11218.
-
(2004)
J Virol
, vol.78
, pp. 11208-11218
-
-
Ritola, K.1
Pilcher, C.D.2
Fiscus, S.A.3
-
27
-
-
0242491896
-
Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression
-
Sagar M, Lavreys L, Baeten JM, et al. Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression. J Virol 2003; 77:12921-12926.
-
(2003)
J Virol
, vol.77
, pp. 12921-12926
-
-
Sagar, M.1
Lavreys, L.2
Baeten, J.M.3
-
28
-
-
0034826484
-
Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa
-
Fideli US, Allen S, Musonda R, et al. Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses 2001; 17:901-910.
-
(2001)
AIDS Res Hum Retroviruses
, vol.17
, pp. 901-910
-
-
Fideli, U.S.1
Allen, S.2
Musonda, R.3
-
29
-
-
33847755116
-
Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
-
This study presents an in-vitro model in which langerin, expressed on Langerhans cells, is a natural barrier to HIV-1 infection. Langerhans cells are positioned within the mucosal epithelia and therefore may trap and degrade virus, preventing transmission to CD4 T cells
-
De Witte L, Nabatov A, Pion M, et al. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med 2007; 13:367-371. This study presents an in-vitro model in which langerin, expressed on Langerhans cells, is a natural barrier to HIV-1 infection. Langerhans cells are positioned within the mucosal epithelia and therefore may trap and degrade virus, preventing transmission to CD4 T cells.
-
(2007)
Nat Med
, vol.13
, pp. 367-371
-
-
De Witte, L.1
Nabatov, A.2
Pion, M.3
-
30
-
-
33847249013
-
-
Hladik F, Sakchalathorn P, Ballweber L, et al. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 2007; 26:257-270. Using an elegant ex-vivo organ culture system, the authors demonstrated that CD4 T cells in the vaginal epithelium can be directly and productively infected by HIV-1, and that this strictly requires CD4 and CCR5. In contrast, infection of Langerhans cells involved endocytosis and was not CD4 and CCR5 dependent. Importantly, this study demonstrated that Langerhans cells are not required to transfer infection to CD4 T cells in this system.
-
Hladik F, Sakchalathorn P, Ballweber L, et al. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 2007; 26:257-270. Using an elegant ex-vivo organ culture system, the authors demonstrated that CD4 T cells in the vaginal epithelium can be directly and productively infected by HIV-1, and that this strictly requires CD4 and CCR5. In contrast, infection of Langerhans cells involved endocytosis and was not CD4 and CCR5 dependent. Importantly, this study demonstrated that Langerhans cells are not required to transfer infection to CD4 T cells in this system.
-
-
-
-
31
-
-
33645046393
-
Selective transmission of CCR5-utilizing HIV-1: The 'gatekeeper' problem resolved?
-
Margolis L, Shattock R. Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved? Nat Rev Microbiol 2006; 4:312-317.
-
(2006)
Nat Rev Microbiol
, vol.4
, pp. 312-317
-
-
Margolis, L.1
Shattock, R.2
-
32
-
-
21644455405
-
Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus
-
Miller CJ, Li Q, Abel K, et al. Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus. J Virol 2005; 79:9217-9227.
-
(2005)
J Virol
, vol.79
, pp. 9217-9227
-
-
Miller, C.J.1
Li, Q.2
Abel, K.3
-
33
-
-
33845949180
-
-
Chomont N, Hocini H, Gresenguet G, et al. Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1. AIDS 2007; 21:153-162. This study demonstrated limited viral diversity in the female genital tract and blood during primary infection, suggesting that the bottleneck occurs at the portal of entry, before dissemination. Viral diversity increased over time and the two compartments became distinct. The results argue against the transmission of multiple variants with selective outgrowth of one dominant variant.
-
Chomont N, Hocini H, Gresenguet G, et al. Early archives of genetically-restricted proviral DNA in the female genital tract after heterosexual transmission of HIV-1. AIDS 2007; 21:153-162. This study demonstrated limited viral diversity in the female genital tract and blood during primary infection, suggesting that the bottleneck occurs at the portal of entry, before dissemination. Viral diversity increased over time and the two compartments became distinct. The results argue against the transmission of multiple variants with selective outgrowth of one dominant variant.
-
-
-
-
34
-
-
23244453195
-
Evidence for frequent reinfection with human immunodeficiency virus type 1 of a different subtype
-
Chohan B, Lavreys L, Rainwater SM, Overbaugh J. Evidence for frequent reinfection with human immunodeficiency virus type 1 of a different subtype. J Virol 2005; 79:10701-10708.
-
(2005)
J Virol
, vol.79
, pp. 10701-10708
-
-
Chohan, B.1
Lavreys, L.2
Rainwater, S.M.3
Overbaugh, J.4
-
35
-
-
29444442970
-
Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
-
Frost SD, Wrin T, Smith DM, et al. Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection. Proc Natl Acad Sci USA 2005; 102:18514-18519.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18514-18519
-
-
Frost, S.D.1
Wrin, T.2
Smith, D.M.3
-
36
-
-
34249940652
-
-
Gray ES, Moore PL, Choge IA, et al. Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. J Virol 2007; 81:6187-6196. This study demonstrates high titer autologous neutralizing antibody in acute/early subtype C infection and its association with Env length and glycosylation.
-
Gray ES, Moore PL, Choge IA, et al. Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. J Virol 2007; 81:6187-6196. This study demonstrates high titer autologous neutralizing antibody in acute/early subtype C infection and its association with Env length and glycosylation.
-
-
-
|