Low-dose doxycycline inhibits bone resorption associated with apical periodontitis

International Endodontic Journal

Volumn 41, Issue 4, 2008, Pages 303-309

  Metzger, Z ^a   Belkin, D ^a   Kariv, N ^a   Dotan, M ^a   Kfir, A ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Apical periodontitis; Bone resorption; Doxycycline; Low dose; Rats

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE;

ANIMAL; ARTICLE; BLOOD; FEASIBILITY STUDY; FEMALE; ORAL DRUG ADMINISTRATION; OSTEOLYSIS; RAT; TOOTH PERIAPICAL DISEASE; WISTAR RAT;

ADMINISTRATION, ORAL; ALVEOLAR BONE LOSS; ANIMALS; ANTI-BACTERIAL AGENTS; DOXYCYCLINE; FEASIBILITY STUDIES; FEMALE; PERIAPICAL PERIODONTITIS; RATS; RATS, WISTAR;

EID: 40249107774     PISSN: 01432885     EISSN: 13652591     Source Type: Journal    
DOI: 10.1111/j.1365-2591.2007.01363.x     Document Type: Article

References (34)

1. Bennet JV, Brito GAC, Riberio RA, Rocha FAC (1966) Simplified, accurate method for antibiotic assay of clinical specimens. Applied Microbiology 14, 170 7.
2. Bezerra MM, Brito GA, Ribeiro RA, Rocha FA (2002) Low-dose doxycycline prevents inflammatory bone resorption in rats. Brazilian Journal of Medical and Biological Research 35, 613 6.
3. Buduneli E, Buduneli N, Vardar-Sengul S et al. (2005) Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. Journal of Periodontology 76, 1927 33.
4. Chang KM, Ramamurthy NS, McNamara TF et al. (1994) Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism. Journal of Periodontal Research 29, 242 9.
5. Ciancio S, Ashley R (1998) Safety and efficacy of sub-antimicrobial dose doxycycline therapy in patients with adult periodontitis. Advances in Dental Research 12, 27 31.
6. Cummings GR, Torabinejad M (2000) Effect of systemic doxycycline on alveolar bone loss after periradicular surgery. Journal of Endodontics 26, 325 7.
7. Golub LM, Ciancio S, Ramamamurthy NS, Leung M, McNamara TF (1990) Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. Journal of Periodontal Research 25, 321 30.
8. Golub LM, Suomalainen K, Sorsa T (1992) Host modulation with tetracyclines and their chemically modified analogues. Current Opinions in Dentistry 2, 80 90.
9. Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T (1998) Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Advances in Dental Research 12, 12 26.
10. Greenstein G (1995) Clinical significance of bacterial resistance to tetracyclines in the treatment of periodontal diseases. Journal of Periodontology 66, 925 32.
11. Greenstein G (2004) Efficacy of subantimicrobial-dose doxycycline in the treatment of periodontal diseases: a critical evaluation. International Journal of Periodontics and Restorative Dentistry 24, 528 43.
12. Grevstad HJ (1993) Doxycycline prevents root resorption and alveolar bone loss in rats after periodontal surgery. Scandinavian Journal of Dental Research 101, 287 91.
13. Grevstad HJ, Boe OE (1995) Effect of doxycycline on surgically induced osteoclast recruitment in the rat. European Journal of Oral Science 103, 156 9.
14. Kakehashi S, Stanley HR, Fitzgerald RJ (1965) The effect of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surgery Oral Medicine Oral Pathology 20, 340 9.
15. Kuo ML, Lamster IB, Hasselgren G (1998a) Host mediators in endodontic exudates. I. Indicators of inflammation and humoral immunity. Journal of Endodontics 24, 598 603.
16. Kuo ML, Lamster IB, Hasselgren G (1998b) Host mediators in endodontic exudates. II. Changes in concentration with sequential sampling. Journal of Endodontics 24, 636 40.
17. Lee HM, Ciancio SG, Tuter G, Ryan ME, Komaroff E, Golub LM (2004) Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug. Journal of Periodontology 75, 453 63.
18. Matsuo T, Ebisu S, Nakanishi T, Yonemura K, Harada Y, Okada H (1994) Interleukin-1 alpha and interleukin-1 beta periapical exudates of infected root canals: correlations with the clinical findings of the involved teeth. Journal of Endodontics 20, 432 5.
19. Metzger Z (2000) Macrophages in periapical lesions. Endodontics and Dental Traumatology 16, 1 8.
20. Metzger Z, Klein H, Klein A, Tagger M (2002) Periapical lesion development in rats inhibited by dexamethasone. Journal of Endodontics 28, 643 5.
21. Pallasch TJ (2003) Antibiotic resistance. Dental Clinics of North America 47, 623 39.
22. Politis AD, Sivo J, Driggers PH, Ozato K, Vogel SN (1992) Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages. Induction by IFN-gamma and down-regulation by IFN-alpha, dexamethasone, and protein kinase inhibitors. Journal of Immunology 148, 801 7.
23. Preshaw PM, Hefti AF, Jepsen S, Etienne D, Walker C, Bradshaw MH (2004a) Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review. Journal of Clinical Periodontology 31, 697 707.
24. Preshaw PM, Hefti AF, Novak MJ et al. (2004b) Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial. Journal of Periodontology 75, 1068 76.
25. Ramamurthy NS, Rifkin BR, Greenwald RA et al. (2002) Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. Journal of Periodontology 73, 726 34.
26. Sasaki T, Ramamurthy NS, Golub LM (1998) Long-term therapy with new chemically modified tetracycline (CMT-8) inhibits bone loss in femurs of ovariectomized rats. Advances in Dental Research 12, 81 7.
27. Shapira L, Houri Y, Barak V, Soskolne WA, Halabi A, Stabholz A (1997) Tetracycline inhibits Porphyromonas gingivalis lipopolysaccharide- induced lesions in vivo and TNF alpha processing in vitro. Journal of Periodontal Research 32, 183 8.
28. Slots J, Rams TE (1990) Antibiotics in periodontal therapy: advantages and disadvantages. Journal of Clinical Periodontology 17, 479 93.
29. Stashenko P, Teles R, D'Souza R (1998) Periapical inflammatory responses and their modulation. Critical Reviews in Oral Biology and Medicine 9, 498 521.
30. Tjäderhane L, Hotakainen T, Kinnunen S, Ahonen M, Salo T (2007) The effect of chemical inhibition of matrix metalloproteinases on the size of experimentally induced apical periodontitis. International Endodontic Journal 40, 282 9.
31. Toth A, Beck FM, Beck EX, Flaxman N, Rosen S (1986) Effect of antimicrobial agents on root surface caries, alveolar bone loss and microflora in rice rats. Journal of Dental Research 65, 695 7.
32. Vernillo AT, Rifkin BR (1998) Effects of tertacyclines on bone metabolism. Advances in Dental Research 12, 56 62.
33. Wang CY, Stashenko P (1993) Characterization of bone-resorbing activity in human periapical lesions. Journal of Endodontics 19, 107 11.
34. Yaffe A, Herman A, Bahar H, Binderman I (2003) Combined local application of tetracycline and bisphosphonate reduces alveolar bone resorption in rats. Journal of Periodontology 74, 1038 42.