Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planning in chronic periodontitis: A multicenter trial

Journal of Periodontology

Volumn 75, Issue 8, 2004, Pages 1068-1076

  Preshaw, Philip M ^a   Hefti, Arthur F ^b   Novak, M John ^c   Michalowicz, Bryan S ^d   Pihlstrom, Bruce L ^e   Schoor, Robert ^f   Trummel, Clarence L ^g   Dean, John ^g   Van Dyke, Thomas E ^h   Walker, Clay B ⁱ   Bradshaw, Mark H ^j  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b PHILIPS RESEARCH LABORATORIES   (Germany)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^f NEW YORK UNIVERSITY   (United States)

^g UNIVERSITY OF CONNECTICUT   (United States)

^h BOSTON UNIVERSITY   (United States)

ⁱ UNIVERSITY OF FLORIDA   (United States)

^j 206 Carnegie Center   (United States)

more..

Author keywords

Adjunctive therapy; Clinical trials, controlled; Double masked method; Doxycycline therapeutic use; Multicenter studies; Periodontitis drug therapy; Planning; Scaling

Indexed keywords

ANTIINFECTIVE AGENT; DOXYCYCLINE; PLACEBO;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BACKACHE; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; ENTEROCOLITIS; FEMALE; FEVER; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INFECTION; INFLUENZA; INTERMETHOD COMPARISON; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAIN; PERIODONTITIS; PHOTOSENSITIVITY DISORDER; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; STANDARD; STATISTICAL SIGNIFICANCE; SUNBURN; THORAX DISEASE; TREATMENT OUTCOME; UROGENITAL TRACT DISEASE;

ADULT; AGED; ANTI-BACTERIAL AGENTS; BIOLOGICAL RESPONSE MODIFIERS; CHEMOTHERAPY, ADJUVANT; DENTAL SCALING; DOUBLE-BLIND METHOD; DOXYCYCLINE; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIODONTITIS;

EID: 4644370370     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.8.1068     Document Type: Article

References (25)

1. Offenbacher S. Periodontal diseases: Pathogenesis. Ann Periodontol 1996;1:821-878.
2. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future directions. Periodontol 2000 1997;14:216-248.
3. Hassell TM. Tissues and cells of the periodontium. Periodontol 2000 1993;3:9-38.
4. Fullmer HM, Gibson W. Collagenolytic activity in gingivae of man. Nature 1966;209:728-729.
5. Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relatiortsbip between neutrophil collagenase activity and periodontal tissue destruction in vivo: Role of active enzyme in human periodontitis. J Periodont Res 1995;30: 23-33.
6. Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infect Immun 1999;67:2319-2326.
7. Reynolds JJ, Meickle MC. Mechanisms of connective tissue matrix destruction in periodontitis. Periodontol 2000 1997;14:144-157.
8. Golub LM, Sorsa T, Lee HM, et al. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 1995;22:100-109.
9. Golub LM, Ciancio SG, Ramamurthy NS, Leung M, McNamara TF. Low-dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans. J Periodontal Res 1990;25:321-330.
10. Golub LM, Lee HM, Greenwald RA, et al. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res 1997;46:310-319.
11. Crout RJ, Lee HM, Schroeder K, et al. The "cyclic" regimen of low-dose doxycycline for adult periodontitis: A preliminary study. J Periodontol 1996;67:506-514.
12. Caton JG, Ciancio SG, Blieden TM, et al. Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. J Periodontol 2000;71:521-532.
13. Walker C, Thomas J, Nango S, Lennon J, Wetzel J, Powala C. Long-term treatment with subantimicrobial dose doxycycline exerts no antibacterial effect on the subgingival microflora associated with adult periodontitis. J Periodontol 2000;71:1465-1471.
14. Pihlstrom BL, McHugh R, Oliphant T, Ortiz-Campos C. Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 6 1/2 years. J Clin Periodontol 1983; 10:524-541.
15. Badersten A, Nilveus RE, Egelberg JH. Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. J Clin Periodontol 1984;11:63-76.
16. Cobb CM. Clinical significance of non-surgical periodontal therapy: An evidence-based perspective of scaling and root planing. J Clin Periodontal 2002;29(Suppl. 2):6-16.
17. Cobb CM. Non-surgical pocket therapy: Mechanical. Ann Periodontol 1996;1:443-490.
18. Hujoel PP, Baab DA, DeRouen TA. Measures of treatment efficacy. J Clin Periodontol 1993;20:601-605.
19. Jeffcoat M. What is clinical significance? J Clin Periodontol 2002;29(Suppl. 2):30-32.
20. Preshaw PM, Heasman PA. How new periodontal therapies are developed and evaluated. Br Dent J 1997;182:149-152.
21. Pihlstrom BL. Measurement of attachment level in clinical trials: Probing methods. J Periodontol 1992;63:1072-1077.
22. Machtei EE, Norderyd J, Koch G, Dunford R, Grossi S, Genco RJ. The rate of periodontal attachment loss in subjects with established periodontitis. J Periodontol 1993; 64:713-718.
23. Kinane DF, Chestnutt IG. Smoking and periodontal disease. Crit Rev Oral Biol Med 2000;11:356-365.
24. Thomas JG, Metheny RJ, Karakiozis JM, Wetzel JM, Crout RJ. Long-term sub-antimicrobial doxycycline (Periostat) as adjunctive management in adult periodontitis: Effects on subgingival bacterial population dynamics. Adv Dent Res 1998;12:32-39.
25. Novak MJ, Johns LP, Miller RC, Bradshaw MH. Adjunctive benefits of subantimicrobial dose doxycycline in the management of severe, generalized, chronic periodontitis. J Periodontol 2002;73:762-769.