Elevation of serum N-terminal pro-brain natriuretic peptide after exercise is an index of myocardial damage or a cytoprotective reflection?

Journal of Sports Medicine and Physical Fitness

Volumn 48, Issue 1, 2008, Pages 92-96

  Faviou, E ^a,b,c   Zachari, A ^a   Nounopoulos, C ^a   Agrafiotis, E ^b   Vourli, G ^a   Dionyssiou Asteriou, A ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Biocheck International   (Greece)

^c Medical School University of Athens ^*  (Greece)

Author keywords

Brain Troponin Heart; Natriuretic peptide; Physiology Physical education and training Physical fitness

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; PEPTIDE FRAGMENT; PRO BRAIN NATRIURETIC PEPTIDE (1 76); PRO-BRAIN NATRIURETIC PEPTIDE (1-76); TROPONIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD; CELL PROTECTION; EXERCISE; FITNESS; HEALTH SURVEY; HEART MUSCLE; HUMAN; MALE; METABOLISM; PATHOLOGY; PHYSICAL EDUCATION; PHYSIOLOGY; PILOT STUDY; SPORTS MEDICINE;

ADULT; BIOLOGICAL MARKERS; CYTOPROTECTION; EXERCISE; HEALTH STATUS INDICATORS; HUMANS; MALE; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; PHYSICAL EDUCATION AND TRAINING; PHYSICAL FITNESS; PILOT PROJECTS; SPORTS MEDICINE; TROPONIN;

EID: 40249099413     PISSN: 00224707     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Maron BJ. Sudden death in young athletes. N Engl J Med 2003;349:1064-75.
2. Cowie MR, Jourdain P, Maisel A, Dahlstrom U, Follath F, Isnard R et al. Clinical application of B-type natriuretic peptide (BNP) testing. Eur Heart J 2003;24:1710-8.
3. De Lemos JA, McGuire DK, Drazner MH. B-Type natriuretic peptide in cardiovascular disease. Lancet 2003;362:316-22.
4. Clerico A, Emdin M. Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a review. Clin Chem 2004;50:33-50.
5. Richards M, Troughton R, Lainchbury J, Doughty R, Wright S. Health gains by using natriuretic peptides in diagnosis, prognosis and treatment. Scand J Clin Lab Invest Suppl 2005;240:129-37.
6. Konig D, Schumacher YO, Heinrich L, Schmid A, Berg A, Dickhuth HH. Myocardial stress after competitive exercise in professional road cyclists. Med Sci Sports Exerc 2003;35:1679-83.
7. Ohba H, Takada H, Musha H, Nagashima J, Mori N, Awaya T et al. Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men. Am Heart J 2001;141:751-8.
8. Neumayr G, Pfister R, Mitterbauer G, Eibl G, Hoertnagl H. Effect of competitive marathon cycling on plasma N-terminal pro-brain natriuretic peptide and cardiac troponin T in healthy recreational cyclists. Am J Cardiol 2005;96:732-5.
9. Herrmann M, Scharhag J, Miclea M, Urhausen A, Herrmann W, Kindermann W. Post-race kinetics of cardiac troponin T and 1 and N-terminal pro-brain natriuretic peptide in marathon runners. Clin Chem 2003;49:831-4.
10. Lijnen P, Hespel P, M'Buyamba-Kabangu JR, Goris M, Lysens R, Vanden Eynde E et al. Plasma atrial natriuretic peptide and cyclic nucleotide levels before and after a marathon. J Appl Physiol 1987;63:1180-4.
11. Tanabe K, Yamamoto A, Suzuki N, Akashi Y, Seki A, Samejima H et al. Exercise-induced changes in plasma atrial natriuretic peptide and brain natriuretic peptide concentrations in healthy subjects with chronic sleep deprivation. Jpn Circ J 1999;63:447-52.
12. Tanaka M, Ishizuka Y, Ishiyama Y, Kato J, Kida O, Kitamura K et al. Exercise-induced secretion of brain natriuretic peptide in essential hypertension and normal subjects. Hypertens Res 1995;18:159-66.
13. Shave R, Dawson E, Whyte G, George K, Ball D, Collinson P et al. The cardiospecificity of the third generation cTnT assay after exercise-induced muscle damage. Med Sci Sports Exerc 2002;34:651-4.
14. Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem 2002;48:1097-100.
15. Neumayr G, Gaenzer H, Pfister R, Sturm W, Schwarzacher SP, Eibl G et al. Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise. Am J Cardiol 2001;87:369-71.
16. Cleve P, Boswell TD, Speedy DB, Boswell DR. Plasma cardiac troponin concentrations after extreme exercise. Clin Chem 2001;47:608-10.
17. Scharhag J, Herrmann M, Urhausen A, Haschke M, Herrmann W, Kindermann W. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J 2005;150:1128-34.
18. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult a report of the American College of Cardiology/American Heart Association task force on practice guidelines. American College of Cardiology Web Site. Available at: http://www.acc.org/ clinical/guidelines/failure//index.pdf.
19. Downie PF, Talwar S, Squire IB, Davies JE, Barnett DB, Ng LL. Assessment of the stability of N-terminal pro-brain natriuretic peptide in vitro: implications for assessment of left ventricular dysfunction. Clin Sci Colch 1999;97:255-8.
20. Wijbenga JA, Balk AH, Boomsma F, Man in't Veld AJ, Hall C. Cardiac peptides differ in their response to exercise. Implications for patients with heart failure. Eur Heart J 1999;20:1424-8.
21. Jernberg T, Venge P, Lindahl B. Comparison between second and third generation troponin T assay in patients with symptoms suggestive of an acute coronary syndrome but without ST segment elevation. Cardiology 2003;100:29-35.
22. Hunt PJ, Yandle TG, Nicholls MG, Richards AM, Espiner EA. The amino-terminal portion of pro-brain natriuretic peptide (pro-BNP) circulates in human plasma. Biochem Biophys Res Commun 1995;214:1175-83.
23. Mueller T, Gegenhuber A, Poelz W, Haltmayer M. Head-to-head comparison of the diagnostic utility of BNP and NT-proBNP in symptomatic and asymptomatic structural heart disease. Clin Chim Acta 2004;341:41-8.
24. Yeo KT, Dumont KE, Brough T. Elecsys NT-ProBNP and BNP assays: are there analytically and clinically relevant differences? J Card Fail 2005;11(5 Suppl):S84-8.
25. Richards AM, Nicholls GM, Yandle TG, Frampton C, Espiner EA, Turner JG et al. Plasma N-terminal pro brain natriuretic peptide and adrenomedullin. New neurohumoral predictors of left ventricular function and prognosis after myocardial infarction. Circulation 1998;97:1921-9.
26. Date H, Imamura T, Onitsuka H, Maeno M, Watanabe R, Nishihira K et al. Differential increase in natriuretic peptides in elite dynamic and static athletes. Circ J 2003;67:691-6.
27. Douglas PS, O'Toole ML, Woolard J. Regional wall motion abnormalities after prolonged exercise in the normal left ventricle. Circulation 1990;82:2108-14.
28. Kasikcioglu E. Cardiac response to prolonged strenuous exercise: a physiologic model for stunning myocardium. Am J Cardiol 2005;95:707.
29. Koller A, Summer P, Moser H. Regular exercise and subclinical myocardial injury during prolonged aerobic exercise. JAMA 1999;282:1816.
30. Koller A, Mair J, Mayr M, Calzolari C, Larue C, Puschendorf B. Diagnosis of myocardial injury in marathon runners. Ann NY Acad Sci 1995;27:234-5.
31. Laslett L, Eisenbud E, Lind R. Evidence of myocardial injury during prolonged strenuous exercise. Am J Cardiol 1996;78:488-90.
32. Nagashima J, Musha H, Takada H. Myocardial injury after an ultra-marathon: echocardiographic assessment during isometric exercise and serum cardiac troponin T level. Int J Sports Cardiol 1999;8:77-82.
33. Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem 2002;48:1097-100.
34. Neumayr N, Pfister R, Mitterbauer G, Gaenzer H, Sturm W, Hoertnagl H. Effect of the bRace across the AlpsQ in elite cyclists on plasma cardiac troponins I and T. Am J Cardiol 2002;89:484-6.
35. Shave R, Dawson E, Whyte G, George K, Ball D, Gaze DC et al. Evidence of exercise-induced cardiac dysfunction and elevated cTnT in separate cohorts competing in an ultra-endurance mountain marathon race. Int J Sports Med 2002;23:489-94.
36. Siegel AJ, Lewandrowski EL, Chun KY, Sholar MB, Fischman AJ, Lewandrowski KB. Changes in cardiac markers including B-natriuretic peptide in runners after the Boston marathon. Am J Cardiol 2001;88:920-3.
37. Shave R, Dawson E, Whyte G, George K, Gaze D, Collinson P. Altered cardiac function and minimal cardiac damage during prolonged exercise. Med Sci Sports Exerc 2004;36:1098-103.
38. George K, Whyte G, Stephenson C, Shave R, Dawson E, Edwards B et al. Postexercise left ventricular function and cTnT in recreational marathon runners. Med Sci Sports Exerc 2004;36:1709-15.
39. Katus HA, Müller-Bardorff M, Hallermayer K, Zuchhold HD, Borgya A, Klein G et al. The second generation of the cardiac troponin T Elisa: improved specificity. Clin Chem 1995;41:S79.
40. Muller-Bardorff M, Hallermayer K, Schroder A, Ebert C, Borgya A, Gerhardt W et al. Improved troponin T ELISA specific for cardiac troponin T isoform: assay development and analytical and clinical validation. Clin Chem 1997;43:458-66.
41. Rifai N, Douglas PS, O'Toole M, Rimm E, Ginsburg GS. Cardiac troponin T and I, electrocardiographic wall motion analyses and ejection fractions in athletes participating in the Hawaii Ironman triathlon. Am J Cardiol 1999;83:1085-9.
42. Urhausen A, Scharhag J, Hermann M, Kindermann W. Clinical significance of increase cardiac troponins T and I participants of ultra-endurance events. Am J Cardiol 2004;94:696-8.
43. Chen Y, Serfass RC, Mackey-Bojack SM, Kelly KL, Titus JL, Apple FS. Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. J Appl Physiol 2000;88:1749-55.
44. Wang J, Larson MG, Levy D, Benjamin EJ, Leip EP, Omland T et al. Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med 2004;350:655-63.
45. Clerico A, Recchia FA, Passino C, Emdin M. Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications. Am J Physiol Heart Circ Physiol 2006;290:H17-29.
46. Scharhag J, Urhausen A, Herrmann M, Schneider G, Kramann B, Herrmann W et al. No difference in N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations between endurance athletes with athlete's heart and healthy untrained controls. Heart 2004;90:1055-6.
47. Omland T, Persson A, Ng L, O'Brien R, Karlsson T, Herlitz J et al. N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes. Circulation 2002;106:2913-8.
48. De Lemos J, Morrow D, Bentley J, Omland T, Sabatine M, McCabe C et al. The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med 2001;345:1014-21.
49. Goetze JP, Christoffersen C, Perko M, Arendrup H, Rehfeld JF, Kastrup J et al. Increased cardiac BNP expression associated with myocardial ischemia. FASEB J 2003;17:1105-7.