Altered cardiac function and minimal cardiac damage during prolonged exercise

Medicine and Science in Sports and Exercise

Volumn 36, Issue 7, 2004, Pages 1098-1103

  Shave, Robert ^a   Dawson, Ellen ^b   Whyte, Gregory ^c   George, Keith ^d   Gaze, David ^e   Collinson, Paul ^e  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b Rigshospitalet   (Denmark)

^c Olympic Medical Institute   (United Kingdom)

^d LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^e ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Diastolic function; Endurance exercise; Heart; Troponin

Indexed keywords

CREATINE KINASE; CREATINE KINASE MB; TROPONIN T;

ADULT; ARTICLE; ATHLETE; BLOOD ANALYSIS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDURANCE; ENZYME ACTIVITY; EXERCISE; HEART FUNCTION; HEART INJURY; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE VOLUME; HEART STROKE VOLUME; HUMAN; HUMAN EXPERIMENT; MALE; RUNNING; STRESS; SWIMMING; SYSTOLIC BLOOD PRESSURE; VENOUS BLOOD;

ADULT; BLOOD PRESSURE; CARDIAC OUTPUT; ELECTROCARDIOGRAPHY; EXERCISE; HEART FUNCTION TESTS; HUMANS; MALE; SENSITIVITY AND SPECIFICITY; TROPONIN C;

EID: 3042849990     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000131958.18154.1E     Document Type: Article

References (30)

1. COLLINSON, P., F. BOA, and D. GAZE. Measurement of cardiac troponins. Ann. Clin. Biochem. 38:423-449, 2001.
2. DAWSON, E., K. GEORGE, R. SHAVE, G. WHYTE, and D. BALL. Does the human heart fatigue subsequent to prolonged exercise. Sports Med. 33:365-380, 2003.
3. DENVIR, M. A., P. J. GALLOWAY, A. S. MEIGHAN, et al. Changes in skeletal and cardiac muscle enzymes during the Scottish coast to coast triathlon. Scot. Med. J. 44:49-51, 1999.
4. DOUGLAS, P., M. O'TOOLE, W. DOUGLAS, B. HILLER, K. HACKNEY, and N. REICHEK. Cardiac fatigue after prolonged exercise. Circulation 76:1206-1213, 1987.
5. DOUGLAS, P., M. O'TOOLE, and J. WOOLARD. Regional wall motion abnormalities after prolonged exercise in the normal left ventricle. Circulation 82:2108-2114, 1990.
6. DOUGLAS, P., M. O'TOOLE, and S. KATZ. Prolonged exercise alters cardiac chronotropic responsiveness in endurance athletes. J. Sports Med. Phys. Fimess 38:158-163, 1998.
7. GERTZ, S., G. URETSKY, R. WAJNBERG, N. NAVOT, and M. GOTSMAN. Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction. Circulation 63:476-486, 1981.
8. GOODMAN, J. M., P. R. McLAUGHLIN, and P. P. LIU. Left ventricular performance during prolonged exercise: absence of systolic dysfunction. Clin. Sci. (Lond.) 100:529-537, 2001.
9. HAYKOWSKY, M., R. WELSH, D. HUMEN, D. WARBURTON, and D. TAYLOR. Impaired left ventricular systolic function after a half-Ironman race. Can. J. Cardiol. 17:687-690, 2001.
10. KOLLER, A., P. SUMMER, and H. MOSER. Regular exercise and subclinical myocardial injury during prolonged aerobic exercise. JAMA 282:1816, 1999.
11. LUCIA, A., L. SERRATOSA, A. SABORIDO, et al, Short-term effects of marathon running: no evidence of cardiac dysfunction. Med. Sci. Sports Exerc. 31:1414-1421, 1999.
12. MCGAVOCK, J., D. WARBURTON, D. TAYLOR, R. WELSH, A. QUINNEY, and M. HAYKOWSKY. The effects of prolonged strenuous exercise on left ventricular function: a brief review. Heart Lung 31:279-292, 2002.
13. MCGAVOCK, J., M. HAYKOWSKY, D. WARBURTON, D. TAYLOR, A. QUINNEY, and R. WELSH. Left ventricular systolic performance during prolonged strenuous exercise in female triathletes. Dyn. Med. 2:2, 2003.
14. NEUMAYR, G., R. PFISTER, G. MITTERBAUER, et al. Effect of the "Race Across The Alps" in elite cyclists on plasma cardiac troponins I and T. Am. J. Cardiol. 89:484-486, 2002.
15. OHBA, H., H. TAKADA, H. MUSHA, et al. Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men. Am. Heart J. 141:751-758, 2001.
16. REICHEK, N., J. WILSON, S. M. ST JOHN, T. A. PLAPPERT, S. GOLDBERG, and J. W. HIRSHFELD. Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application. Circulation 65:99-108, 1982.
17. REMPPIS, A., T. SCHEFFOLD, J. GRETEN, et al. Intracellular compartmentation of troponin T: release kinetics after global ischemia and calcium paradox in the isolated perfused rat heart. J. Mol. Cell Cardiol. 27:793-803, 1995.
18. RIFAI, N., P. S. DOUGLAS, M. O'TOOLE, E. RIMM, and G. S. GINSBERG. Cardiac troponin T and I, electrocardiographic wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman triathlon. Am. J. Cardiol. 83:1085-1089, 1999.
19. ROWE, W. J. Endurance exercise and injury to the heart. Sports Med. 16:73-79, 1993.
20. SAHN, D., A. DEMARIA, J. KISSLO, and A. WEYMAN. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 58:1072-1083, 1978,
21. SHAVE, R., E. DAWSON, G. WHYTE, et al. The cardiospecificity of the third-generation cTnT assay after exercise-induced muscle damage. Med. Sci. Sports Exerc. 34:651-654, 2002.
22. SHAVE, R., E. DAWSON, G. WHYTE, et al. Evidence of exercise-induced cardiac dysfunction and elevated cTnT in separate cohorts competing in an ultra-endurance mountain marathon race. Int. J. Sports Med. 23:489-494, 2002,
23. SHAVE, R., G. WHYTE, E. DAWSON, K. GEORGE, D. GAZE, and P. COLLINSON. The impact of prolonged exercise upon markers of cardiac function and damage. Med. Sci. Sports Exerc. 35:s120, 2003.
24. SHAVE, R., E. DAWSON, G. WHYTE, K. GEORGE, D. GAZE, and P. COLLINSON. Effect of prolonged exercise in a hypoxic environment on cardiac function and cardiac troponin T. Br. J. Sports Med. 38:86-88, 2004.
25. SIEGEL, A., M. SCHOLAR, J. YANG, E. DHANAK, and K. LEWAND-ROWSKI. Elevated serum cardiac markers in asymptomatic marathon runners after competition: is the myocardium stunned? Cardiology 88:487-491, 1997.
26. STARNES, J., and D. BOWLES. Role of exercise in the cause and prevention of cardiac dysfunction. Exerc. Sport Sci. Rev. 23:349-374, 1995.
27. VANOVERSCHELDE, J., L. YOUNIS, J. MELIN, et al. Prolonged exercise induces left ventricular dysfunction in healthy subjects. J. Appl. Physiol. 70:1356-1363, 1991.
28. VENDITTI, P., and S. DI MEO. Antioxidants, tissue damage, and endurance in trained and untrained young male rats. Arch. Biochem. Biophys. 331:63-68, 1996.
29. WHYTE, G., K. GEORGE, S. SHARMA, et al. Cardiac fatigue following prolonged endurance exercise of differing distances. Med. Sci. Sports Exerc. 32:1067-1072, 2000.
30. Wu, A. H. B., R. VALDES JR., F. S. APPLE, et al. Cardiac troponin-T immunoassay for diagnosis of acute myocardial infarction. Clin. Chem. 40:900-907, 1994.