Vulnerable and frail elderly: An approach to the management of the main tumour types

European Journal of Cancer

Volumn 44, Issue 4, 2008, Pages 488-493

  Monfardini, Silvio ^a   Gridelli, Cesare ^b   Pasetto, Lara M ^a   Soubeyran, Pierre ^c   Droz, Jean Pierre ^d   Basso, Umberto ^a  

^a VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^b S G MOSCATI HOSPITAL   (Italy)

^c INSTITUT BERGONIÉ   (France)

^d CENTRE LÉON BÉRARD   (France)

Author keywords

Breast cancer; Cancer in the elderly; Colorectal cancer; Frailty; Non Hodgkin's Lymphoma; Prostate cancer; Vulnerability

Indexed keywords

AROMATASE INHIBITOR; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; FULVESTRANT; GEFITINIB; GEMCITABINE; HEMOPOIETIC GROWTH FACTOR; IRINOTECAN; METHOTREXATE; NAVELBINE; OXALIPLATIN; PACLITAXEL; PREDNISONE; RITUXIMAB; SORAFENIB; TAMOXIFEN; TAXANE DERIVATIVE; UNINDEXED DRUG; VANDETANIB; VINCRISTINE;

ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER THERAPY; CLINICAL TRIAL; COLORECTAL CANCER; COMBINATION CHEMOTHERAPY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; FRAIL ELDERLY; HIGH RISK PATIENT; HUMAN; LUNG NON SMALL CELL CANCER; MONOTHERAPY; NEPHROTOXICITY; NEUROTOXICITY; NONHODGKIN LYMPHOMA; OTOTOXICITY; PRIORITY JOURNAL; PROSTATE CANCER; THROMBOEMBOLISM; VOMITING;

AGED; ANTINEOPLASTIC AGENTS; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMANS; NEOPLASMS; VULNERABLE POPULATIONS;

EID: 40249088147     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.01.002     Document Type: Article

References (47)

1. Rubenstein L.Z., Josephson K.R., Wieland G.D., English P.A., Sayre J.A., and Kane R.L. Effectiveness of a geriatric assessment unit: a randomized clinical trial. N Engl J Med 311 (1984) 1664-1671
2. Monfardini S., Ferrucci L., Fratino L., Del Lungo I., Serraino D., and Zagonel V. Validation of a multidimensional evaluation scale for use in elderly cancer patients. Cancer 77 (1996) 395-401
3. Extermann M., Overcash J., Lyman G.H., Parr J., and Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 16 (1998) 1582-1587
4. Repetto L., Fratino L., Audisio R.A., et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol 20 2 (2002) 494-502
5. Monfardini S., Fratino L., Zagonel V., Abu Rumeileh I., and Serraino D. Elderly cancer patients (pts) undergoing chemotherapy or radiotherapy should be tested for their ability in drug self-administration, use of means of transportation and telephone. Proc Am Soc Clin Oncol 15 (1996) abstr1628
6. Monfardini S., Pasetto L., Jirillo A., et al. "Taking care of older cancer patients: results of a survey addressed to the Chiefs of the Medical Oncology". Crit Rev Oncol Hematol 58 1 (2006) 53-59
7. Monfardini S., Aapro M.S., Bennett J.M., et al. Organization of the clinical activity of Geriatric Oncology: Report of a SIOG (International Society of Geriatric Oncology) task force. Crit Rev Oncol Hematol 62 (2007) 62-73
8. Saliba D., Orlando M., Wenger N.S., Hays R.D., and Rubensteine L.Z. Identifying a short functional disability screen for older persons. J Gerontol 55 (2000) M750-M756
9. Overcash J.A., Beckstead J., Extermann M., et al. The abbreviated comprehensive geriatric assessment (aCGA): retrospective analysis. Crit Rev Oncol Hematol 54 (2005) 129-136
10. Soubeyran P., Rainfray M., Mathoulin-Pelissier S., et al. Prediction of early death risk in the elderly with cancer: results of a prospective multicentric study of 364 patients under chemotherapy. J Clin Oncol 25 18s (2007) abstr 9040
11. Basso U., Brunello A., Pogliani C., and Monfardini S. Treatment options for early breast cancer in the elderly. Exp Rev Anticancer Therapy 4 (2004) 197-211
12. Extermann M., Meyer J., McGinnis M., et al. A comprehensive geriatric intervention detects multiple problems in older breast cancer patients. Crit Rev Oncol Hematol 49 (2004) 69-75
13. Monfardini S., Brunello A., Molino A., et al. Comorbidity and choice of adjuvant endocrine therapy in breast cancer patients (pts) older than 70 years. Proc Am Soc Clin Oncol (2006) 24 abstr 8546
14. Nabholtz J.M., and Gligorov J. Cardiovascular safety profiles of aromatase inhibitors: a comparative review. Drug Saf 29 (2006) 785-801
15. Chien A.J., and Goss P.E. Aromatase Inhibitors and bone health in women with breast cancer. J Clin Oncol 20 (2006) 5305-5312
16. Monfardini S., and Basso U. Do older women with breast cancer benefit from adjuvant chemotherapy?. Nat Clin Pract Oncol 3 (2006) 652-653
17. Extermann M., Balducci L., and Lyman G.H. What threshold for adjuvant therapy in older breast cancer patients?. J Clin Oncol 18 (2000) 1709-1717
18. Rossi A., Gridelli C., Gebbia V., et al. Single agent vinorelbine as first-line chemotherapy in elderly patients with advanced breast cancer. Anticancer Res 23 (2003) 1657-1664
19. Basso U., Fratino L., Brunello A., et al. Which benefit from adding gemcitabine to vinorelbine in elderly (>or=70 years) women with metastatic breast cancer? Early interruption of a phase II study. Ann Oncol 18 (2007) 58-63
20. Addeo R, Faiola V, Guarrasi R, et al. Liposomal pegylated doxorubicin plus vinorelbine combination as first-line chemotherapy for metastatic breast cancer in elderly women >/=65 years of age. Cancer Chemother Pharmacol epub ahead of print, 9 Oct 2007.
21. Wildiers H., and Paridaens R. Taxanes in elderly breast cancer patients. Cancer Treat Rev 30 (2004) 333-342
22. Bajetta E., Procopio G., Celio L., et al. Safety and efficacy of two different doses of capecitabine in the treatment of advanced breast cancer in older women. J Clin Oncol 23 (2005) 2155-2161
23. Del Mastro L., Perrone F., Repetto L., et al. Gruppo Italiano di Oncologia Geriatrica (GIOGer). Weekly paclitaxel as first-line chemotherapy in elderly advanced breast cancer patients: a phase II study of the Gruppo Italiano di Oncologia Geriatrica (GIOGer). Ann Oncol 6 (2005) 253-258
24. Hamberg P., Verweij J., and Seynaeve C. Cytotoxic therapy for the elderly with metastatic breast cancer: a review on safety, pharmacokinetics and efficacy. Eur J Cancer 43 (2007) 1514-1528
25. Gridelli C., Aapro M., Ardizzoni A., et al. Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel. J Clin Oncol 23 (2005) 3125-3137
26. Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) Group. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 91 (1999) 66-72
27. Gridelli C., Perrone F., Gallo C., et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst 95 (2003) 362-372
28. Perrone F., Gallo C., and Gridelli C. Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: Implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst 94 (2002) 1029-1030
29. Jackman D.M., Yeap B.Y., Lindeman N.I., et al. Phase II clinical trial of chemotherapy-nai{dotless}̈ve patients > or = 70 years of age treated with erlotinib for advanced non small cell lung cancer. J Clin Oncol 25 (2007) 760-766
30. Crinò L., Zatlukal S., Reck P., et al. Gefitinib (IRESSA) versus vinorelbine in chemonaive elderly patients with advanced non small cell lung cancer (INVITE): a randomized phase II study. J Thorac Oncol 8 (2007) S341
31. Newschaffer C.J., Otani K., McDonald K., and Penberthy L.T. Causes of death in elderly prostate cancer patients and in a comparison nonprostate cancer cohort. J Natl Cancer Inst 92 (2000) 613-621
32. Terret C., Albrand G., and Droz J.P. Geriatric assessment in elderly patients with prostate cancer. Clin Prostate Cancer 2 (2004) 236-240
33. Mohile S.G., Bylow K., Dale W., et al. A pilot study of the Vulnerable Elders Survey-13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation. Cancer 109 (2007) 802-810
34. Joly F., Alibhai S.M.H., Galica J., et al. Impact of androgen deprivation therapy on physical and cognitive function, as well as quality of life of patients with nonmetastatic prostate cancer. J Urol 176 (2006) 2443-2447
35. Bylow K, Mohile SG, Stakler WM, Dale W. Does androgen-deprivation therapy accelerate the development of frailty in older men with prostate cancer? Cancer epub 24 Oct 2007.
36. Studer U.E., Hauri D., Hanselmann S., et al. Immediate versus deferred hormonal treatment for patients with prostate cancer who are not suitable for curative local treatment: Results of the randomized trial SAKK 08/88. J Clin Oncol 22 (2004) 4109-4118
37. Beer T.M., Berry W., Wersinger E.M., and Bland L.B. Weekly docetaxel in elderly patients with prostate cancer: efficacy and toxicity in patients at least 70 years of age compared with patients younger than 70 years. Clin Prostate Cancer 2 (2003) 167-172
38. Droz J.P., and on behalf of the SIOG taskforce. Guidelines on the treatment of elderly prostate cancer patients. Crit Rev Oncol Hematol 60 (2006) S9
39. Body J.J., Coleman R., Clezardin P., Ripamonti C., Rizzoli R., and Aapro M. International Society of Geriatric Oncology. International Society of Geriatric Oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients. Eur J Cancer 43 (2007) 852-858
40. Sargent D.J., Goldberg R.M., Jacobson S.D., et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. New Engl J Med 345 (2001) 1091-1097
41. Yellen S.B., Cella D.F., and Leslie W.T. Age and clinical decision making in oncology patients. J Natl Cancer Inst 86 (1994) 1766-1770
42. Fratino L, Serraino D, Rossi E, Lonardi S, Monfardini S. Survival of elderly patients with metastatic colorectal cancer is improved by inclusion in phase II trials. 4th Meeting of International Society of Geriatric Oncology, Rome, 21-22 November 2003:abstr74.
43. Monfardini S., and Carbone A. Non-Hodgkin's Lymphomas. In Comprehensive geriatric oncology (1998) 577-594
44. Coiffier B., Lepage E., Briere J., et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B-cell lymphoma. N Engl J Med 346 (2002) 235-242
45. Spina M., Balzarotti M., Lilj U., et al. Comprehensive Geriatric assessment-adapted chemotherapy in 100 elderly patients (>70 years) with diffuse large b-cell non-Hodgkin's lymphoma (DLBCL). Blood 108 (2006) abstr 2440
46. Hamlin PA. Treatment of aggressive Non-Hodgkin's and Hodgkin Lymphoma in older patients. 43rd Annual Meeting of American Society of Clinical Oncology-Educational Book 2007;12:295-299.
47. Monfardini S., Aversa S.M., Zoli V., et al. Vinorelbine and prednisone in frail elderly patients with internediate-high grade non-Hodgkin's lymphomas. Ann Oncol 16 (2005) 1352-1358