Protein kinase C synergistically stimulates tumor necrosis factor-α-induced secretion of urokinase-type plasminogen activator in human dental pulp cells

Journal of Physiological Sciences

Volumn 58, Issue 1, 2008, Pages 83-86

  Hashizume, Hideki ^a   Kamio, Naoto ^a   Nakao, Sumi ^a   Matsushima, Kiyoshi ^a   Sugiya, Hiroshi ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Protein kinase C; TNF ; Urokinase type plasminogen activator

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ENZYME ANTIBODY; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UROKINASE;

ARTICLE; CELL; CELL STIMULATION; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; TOOTH PULP;

CARCINOGENS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DENTAL PULP; DRUG SYNERGISM; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDOLES; MOLAR; PROTEIN KINASE C; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA; URINARY PLASMINOGEN ACTIVATOR;

EID: 40149093563     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.2170/physiolsci.SC013607     Document Type: Article

References (28)

1. Morand MA, Schilder H, Blondin J, Stone PJ, Franzblau C. Collagenolytic and elastinolytic activities from diseased human dental pulps. J Endodont. 1981;7:156-60.
2. Zehnder M, Delaleu N, Du Y, Bickel M. Cytokine gene expression - part of host defense in pulpititis. Cytokine. 2003;22:84-8.
3. Dinarello CA. Proinflammatory cytokines. Chest. 2000;118:503-508.
4. Tani-Ishii N, Wang CY, Stashenco P. Immunolocalization of bone-responsive cytokines in rat pulp and periapical lesions following surgical pulp exposure. Oral Microbiol Immunol. 1995;10:213-9.
5. Blesta A, Berggreen E, Fristad I, Tenstad O, Wiig H. Cytokine signaling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammation. J Physiol. 2006;573:225-36.
6. Pezelj-Ribaric S, Anic I, Brekalo I, Miletic I, Hasan M, Simunovic-Soskic M. Detection of tumor necrosis factor ? in normal and inflamed human dental pulps. Archs Medical Res. 2002;33:482-4.
7. Kokkas AB, Goulas A, Varsamidis K, Mirtsou V, Tziafas D. Irreversible but not reversible pulpitis is associated with up-regulation of tumor necrosis factor-alpha gene expression in human dental pulp. Int Endodont J. 2007;40:198-203.
8. Panagakos FS, O'Boskey FJ Jr, Rodriguez E. Regulation of pulp cell matrix metalloproteinase production by cytokine and lipopolysaccharides. J Endodont. 1996;22:358-61.
9. O'Boskey FJ Jr, Panagakos FS. Cytokines stimulate matrix metalloproteinase production by human dental pulp cells during long-term culture. J Endodont. 1998;24:7-10.
10. Lin SK, Wang CC, Huang S, Lee JJ, Chiang CP, Lan WH, Hong CY. Induction of dental pulp fibroblast metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene by expression interleukin 1 α and tumor necrosis factor-α through prostaglandin-dependent pathway. J Endodont. 2001;27:185-9.
11. Wun TC. Plasminogen activation: biochemistry, physiology, and therapeutics. Crit Rev Biotechnol. 1988;8:131-48.
12. Saksela O. Plasminogen activation and regulation of pericellular proteolysis. Biochim Biophys Acta. 1985;823:35-65.
13. Irigoyen JP, Muñoz-Cánoves P, Montero L, Koziczak M and Nagamine Y. The plasminogen activator system: biology and regulation. Cell Mol Life Sci. 1999;56:104-32.
14. Ueda I, Matsushima K. Stimulation of plasminogen activator activity and matrix metalloproteinases of human dental pulp-derived cells by tumor necrosis factor-α. J Endodont. 2001;27:175-9.
15. Chang YC, Yang SF, Huang FM, Liu CM, Tai KW, Hsieh YS. Induction of tissue plasminogen activator gene expression by proinflammatory of cytokines in human pulp and gingival fibroblasts. J Endodont. 2003;29:114-7.
16. Sundqvist G, Rosenquist JB, Lerner UH. Effects of bradykinin and thrombin on prostaglandin formation, cell proliferation nd collagen biosynthesis in human dental-pulp fibroblasts. Archs Oral Biol, 1995;40:247-56.
17. Pfeilschifter J, Erdmann J, Schmidt W, Naumann A, Minne HW, Ziegler R. Differential regulation of plasminogen activator and plasminogen activator inhibitor by osteotropic factors in primary cultures of mature osteoblasts and osteoblast precursors. Endocrinol. 1990;126,703-11.
18. Kamio N, Hashizume H, Nakao S, Matsushima K, Sugiya H. IL-1β stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells. Biomed Res. 2007;28:315-22.
19. Niedbala MJ, Stein-Picarella M. Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator. Blood. 1993;81:2608-17.
20. Kobayashi H, Gothh J, Terao T. Urinary trypsin inhibitor efficiently inhibits urokinase production in tumor necrosis factor-stimulated cells. Eur J Cell Biol. 1996;71:380-6.
21. Davis PD, Hill CH, Keech E, Lawton G, Nixon JS, Sedgwick AD, Wadsworth J, Westmacott D, Wilkinson SE. Potent selective inhibitors of protein kinase C. FEBS Lett. 1989;259:61-3.
22. van Dijk MCM, Muriana FJG, van der Hoeven PCJ, de Widt J, Schaap D, Moolenaar WH, van Blitterswijk WJ. Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-ζ. Biochem J. 1997;323:693-9.
23. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets fro modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol. 2005;70:1537-47.
24. Breitkreutz D, Braiman-Wiksman L, Daum N, Denning MF, Tennenbaum T. Protein kinase C family: On the crossroads of cell signaling in skin and tumor epithlium. J Cancer Res Clin Oncol. 2007;133:793-808.
25. Mahanivong C, Chen HM, Yee SW, Pan ZK, Dong Z, Huang S. Protein kinase Cα-CARMA3 signaling axis links Ras to NF-κB for lysophoshatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. Oncogene, 2007 (online publication).
26. Amos S, Mut M, diPierro CG, Carpenter JE, Xiao A, Kohutek ZA, Redpath GT, Zhao Y, Wang J, Shaffrey ME, Husssaini IM. Protein kinase C-α-mediated regulation of low-density lipoprotein receptor-related protein and urokinase increases astrocytoma invasion. Cancer Res, 2007;67:10241-51.
27. Grossoni VC, Falbo KB, Mauro LV, Krasnapolski MA, Kazanietz MG, Bal De Kier Joffé ED, Urtreger AJ. Protein Kinase C δ inhibits the production of proteolytic enzymes in murine mammary cells. Clin Exp Metastasis, 2007;24:513-20.
28. Redig RH, Platanias LC. The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis. J Interferon Cytokine Res. 2007;27:623-36.