1,8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N,N-diethyl[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides with a new substitution pattern on the triazole ring

European Journal of Medicinal Chemistry

Volumn 43, Issue 3, 2008, Pages 584-594

  Di Braccio, Mario ^a   Grossi, Giancarlo ^a   Roma, Giorgio ^a   Piras, Daniela ^a   Mattioli, Francesca ^a   Gosmar, Marzia ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Anti inflammatory activity; 1,2,4 Triazolo 4,3 a 1,8 naphthyridine 6 carboxamide derivatives

Indexed keywords

1,8 NAPHTHYRIDINE DERIVATIVE; 2 HYDRAZINO 2 OXO N,N DIPROPYLACETAMIDE; 2 HYDRAZINO N,N DIISOPROPYL 2 OXOACETAMIDE; 3 HYDRAZINO 3 OXO N (2 THIAZOLYL)PROPANAMIDE; 3 HYDRAZINO N ISOBUTYL 3 OXOPROPANAMIDE; 5 (BUTYLAMINO) N,N DIETHYL 9 [2 (ISOBUTYLAMINO) 2 OXOETHYL][1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 5 CHLORO N,N DIETHYL 9 [2 (ISOBUTYLAMINO) 2 OXOETHYL][1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 5 CHLORO N,N DIETHYL 9 [2 OXO 2 (2 THIAZOLYLAMINO)ETHYL][1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 5 CHLORO N,N,N',N' TETRAETHYL[1,2,4]TIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6,9 DICARBOXAMIDE; 5 [ACETYL(ISOBUTYL)AMINO] N,N DIETHYL 9 ISOPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; 9 ALKYL N,N DIALKYL 5 (ALKYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE DERIVATIVE; ETHYL 2 HYDRAZINO 2 OXOACETIC ACID; ETHYL 2 [6 [(DIETHYLAMINO)CARBONYL] 5 (ISOBUTYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 9 YL]PROPANOIC ACID; ETHYL 3 HYDRAZINO 2 METHYL 3 OXOPROPANOIC ACID; ETHYL 3 HYDRAZINO 3 OXOPROPANOIC ACID; ETHYL 6 [(DIETHYLAMINO)CARBONYL] 5 (ISOBUTYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDIN 9 CARBOXYLIC ACID; ETHYL [6 [(DIETHYLAMINO)CARBONYL] 5 (ETHYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 9 YL]ACETIC ACID; ETHYL [6 [(DIETHYLAMINO)CARBONYL] 5 (ISOBUTYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 9 YL]ACETIC ACID; INDOMETACIN; N 6,N 6 DIETHYL 5 (ISOBUTYLAMINO) N 9,N 9 DIPROPYL[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6,9 DICARBOXAMIDE; N,N DIETHYL 2 HYDRAZINO 2 OXOACETAMIDE; N,N DIETHYL 5 (ISOBUTYLAMINO) 9 [2 (ISOBUTYLAMINO) 2 OXOETHYL][1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N DIETHYL 5 (ISOBUTYLAMINO) 9 [2 OXO 2 (2 THIAZOLYLAMINO)ETHYL][1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N,9 TRIETHYL 5 [ETHYL(PYRIDIN 3 YLCARBONYL)AMINO][1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6 CARBOXAMIDE; N,N,N',N' TETRAETHYL 5 (ISOBUTYLAMINO)[1,2,4]TRIAZOLO[4,3 A][1,8]NAPHTHYRIDINE 6,9 DICARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PAW EDEMA; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 40049112702     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.04.016     Document Type: Article

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