Effect of dexamethasone on skeletal muscle Na+,K+ pump subunit specific expression and K+ homeostasis during exercise in humans

Journal of Physiology

Volumn 586, Issue 5, 2008, Pages 1447-1459

  Nordsborg, Nikolai ^a   Ovesen, Jakob ^a   Thomassen, Martin ^a   Zangenberg, Mathias ^a   Jøns, Christian ^a   Iaia, F Marcello ^a   Nielsen, Jens Jung ^a   Bangsbo, Jens ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA2; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) BETA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) BETA2; DEXAMETHASONE; LACTIC ACID; PLACEBO; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA1 SUBUNIT; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA2 SUBUNIT; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) BETA1 SUBUNIT; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) BETA2 SUBUNIT; POTASSIUM ION;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD ANALYSIS; BLOOD FLOW; CHEMICAL ANALYSIS; CLINICAL PROTOCOL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EXERCISE; EXERCISE INTENSITY; EXHAUSTION; FEMORAL ARTERY; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MEMBRANE DEPOLARIZATION; MUSCLE BIOPSY; NORMAL HUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RANDOMIZED CONTROLLED TRIAL; RANGE OF MOTION; SKELETAL MUSCLE; YOUNG ADULT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG MECHANISM; ENZYME REGULATION; EXERCISE PHYSIOLOGY; EXERCISE TOLERANCE; FEMORAL VEIN; MUSCLE BLOOD FLOW; MUSCLE FUNCTION; POTASSIUM BALANCE; PROTEIN ANALYSIS; THIGH; TREATMENT DURATION;

ADULT; DEXAMETHASONE; DOUBLE-BLIND METHOD; EXERCISE; GLUCOCORTICOIDS; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; LACTATES; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; POTASSIUM; PROTEIN SUBUNITS; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 40049106479     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.143073     Document Type: Article

References (53)

1. Adhihetty PJ, Irrcher I, Joseph AM, Ljubicic V & Hood DA (2003). Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol 88, 99-107.
2. +-ATPase in skeletal muscle: potential mechanism for changes in pump cell-surface abundance and activity. Ann N Y Acad Sci 986, 449-452.
3. Andersen P, Adams RP, Sjogaard G, Thorboe A & Saltin B (1985). Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59, 1647-1653.
4. + transport in rat soleus muscle. Am J Physiol Cell Physiol 264, C419-C429.
5. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
6. Bergstrom J (1962). Muscle electrolytes in man. Scand J Clin Lab Invest 68, 1-110.
7. Blanco G & Mercer RW (1998). Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function. Am J Physiol Renal Physiol 275, F633-F650.
8. Bloor CM (2005). Angiogenesis during exercise and training. Angiogenesis 8, 263-271.
9. Bossuyt J, Despa S, Martin JL & Bers DM (2006). Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. J Biol Chem 281, 32765-32773.
10. Brotman DJ, Girod JP, Garcia MJ, Patel JV, Gupta M, Posch A, Saunders S, Lip GY, Worley S & Reddy S (2005). Effects of short-term glucocorticoids on cardiovascular biomarkers. J Clin Endocrinol Metab 90, 3202-3208.
11. o on membrane potential and contraction in mouse fast- and slow-twitch muscle. Am J Physiol Cell Physiol 273, C598-C611.
12. + pump regulation and skeletal muscle contractility. Physiol Rev 83, 1269-1324.
13. Crambert G, Fuzesi M, Garty H, Karlish S & Geering K (2002). Phospholemman (FXYD1) associates with Na, K-ATPase and regulates its transport properties. Proc Natl Acad Sci U S A 99, 11476-11481.
14. 3H]ouabain binding capacity of skeletal muscle in relatives of patients with type 2 diabetes: effect of dexamethasone. Metabolism 51, 1331-1339.
15. + pumps in the transverse-tubular system of skeletal muscle fibers preferentially use ATP from glycolysis. Am J Physiol Cell Physiol 293, C967-C977.
16. + pump in rat skeletal muscle. Am J Physiol Cell Physiol 266, C925-C934.
17. +-ATPase activity in untrained and trained individuals. J Appl Physiol 93, 1650-1659.
18. Friedberg RC, Souers R, Wagar EA, Stankovic AK & Valenstein PN (2007). The origin of reference intervals. Arch Pathol Lab Med 131, 348-357.
19. Harmer AR, McKenna MJ, Sutton JR, Snow RJ, Ruell PA, Booth J, Thompson MW, Mackay NA, Stathis CG, Crameri RM, Carey MF & Eager DM (2000). Skeletal muscle metabolic and ionic adaptations during intense exercise following sprint training in humans. J Appl Physiol 89, 1793-1803.
20. Hellsten Y, Richter EA, Kiens B & Bangsbo J (1999). AMP deamination and purine exchange in human skeletal muscle during and after intense exercise. J Physiol 520, 909-920.
21. Henriksen JE, Alford F, Vaag A, Handberg A & Beck-Nielsen H (1999). Intracellular skeletal muscle glucose metabolism is differentially altered by dexamethasone treatment of normoglycemic relatives of type 2 diabetic patients. Metabolism 48, 1128-1135.
22. +-ATPase is muscle type-specific. FEBS Lett 328, 253-258.
23. James JH, Fang CH, Schrantz SJ, Hasselgren PO, Paul RJ & Fischer JE (1996). Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis. J Clin Invest 98, 2388-2397.
24. Jensen L, Bangsbo J & Hellsten Y (2004). Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle. J Physiol 557, 571-582.
25. Jones PR & Pearson J (1969). Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults. J Physiol 204, 63P-66P.
26. Juel C (1988). Muscle action potential propagation velocity changes during activity. Muscle Nerve 11, 714-719.
27. Juel C (1997). Lactate-proton cotransport in skeletal muscle. Physiol Rev 77, 321-358.
28. Juel C, Bangsbo J, Graham T & Saltin B (1990). Lactate and potassium fluxes from human skeletal muscle during and after intense, dynamic, knee extensor exercise. Acta Physiol Scand 140, 147-159.
29. + pump subunits to the plasma membrane in rat skeletal muscle. Pflugers Arch 443, 212-217.
30. + pump subunits to the plasma membrane in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 278, R1107-R1110.
31. + in human skeletal muscle during and after dynamic graded exercise determined by microdialysis. Am J Physiol Regul Integr Comp Physiol 278, R400-R406.
32. Krustrup P, Hellsten Y & Bangsbo J (2004). Intense interval training enhances human skeletal muscle oxygen uptake in the initial phase of dynamic exercise at high but not at low intensities. J Physiol 559, 335-345.
33. Kuiack S & McComas A (1992). Transient hyperpolarization of non-contracting muscle fibres in anaesthetized rats. J Physiol 454, 609-618.
34. + ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 365, 871-875.
35. Lowry OH & Passonneau JV (1972). A Flexible System of Enzymatic Analysis, pp. 237-249. Academic Press, New York .
36. Macdonald JE & Struthers AD (2004). What is the optimal serum potassium level in cardiovascular patients? J Am Coll Cardiol 43, 155-161.
37. +-pump activity and delays fatigue during prolonged exercise in humans. J Physiol 576, 279-288.
38. + regulation. J Appl Physiol 75, 173-180.
39. Medbo JI & Sejersted OM (1990). Plasma potassium changes with high intensity exercise. J Physiol 421, 105-122.
40. + changes during intense exercise in endurance-trained and sprint-trained subjects. Acta Physiol Scand 151, 363-371.
41. Nielsen JJ, Mohr M, Klarskov C, Kristensen M, Krustrup P, Juel C & Bangsbo J (2004). Effects of high-intensity intermittent training on potassium kinetics and performance in human skeletal muscle. J Physiol 554, 857-870.
42. + pump activity by muscle group specific mechanisms in humans. J Physiol 567, 583-589.
43. Nordsborg N, Mohr M, Pedersen LD, Nielsen JJ, Langberg H & Bangsbo J (2003). Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise. Am J Physiol Regul Integr Comp Physiol 285, R143-R148.
44. 2+ uptake in smooth muscle plasma membrane vesicles by an endogenous glycolytic cascade. FASEB J 3, 2298-2301.
45. Perez G, Abraira C, Oster JR, Lespier L & Vaamonde CA (1975). The effect of dexamethasone on urinary acidification. Proc Soc Exp Biol Med 150, 606-611.
46. + channels. Am J Physiol Cell Physiol 277, C937-C947.
47. Ruff RL, Simoncini L & Stuhmer W (1988). Slow sodium channel inactivation in mammalian muscle: a possible role in regulating excitability. Muscle Nerve 11, 502-510.
48. Sawka MN, Convertino VA, Eichner ER, Schnieder SM & Young AJ (2000). Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sports Exerc 32, 332-348.
49. Singh BN, Hollenberg NK, Poole-Wilson PA & Robertson JI (1992). Diuretic-induced potassium and magnesium deficiency: relation to drug-induced QT prolongation, cardiac arrhythmias and sudden death. J Hypertens 10, 301-316.
50. Street D, Nielsen JJ, Bangsbo J & Juel C (2005). Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium. J Physiol 566, 481-489.
51. 1-subunit abundance and mRNA in rat skeletal muscle. Am J Physiol Cell Physiol 280, C509-C516.
52. Vollestad NK, Hallen J & Sejersted OM (1994). Effect of exercise intensity on potassium balance in muscle and blood of man. J Physiol 475, 359-368.
53. Zhang SJ, Bruton JD, Katz A & Westerblad H (2006). Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle. J Physiol 572, 551-559.