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Volumn 24, Issue 2, 2008, Pages 129-134

Advances in coeliac disease

Author keywords

Coeliac disease; Cytokines; Gluten free diet; Interleukin

Indexed keywords

CD163 ANTIGEN; HLA DQ2 ANTIGEN; HLA DQB1 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

EID: 40049103929     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3282f3d95d     Document Type: Review
Times cited : (8)

References (44)
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    • Salmi TT, Collin P, Korponay-Szabo IR, et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006; 55:1746-1753. These Finnish authors set out to evaluate the clinical and histological features of EMA-negative coeliac disease, and to examine whether EMA equivalent autoantibodies against tTG can be seen in the small bowel mucosa when absent in the serum. They concluded that the detection of tTG in small bowel mucosa may be of future use, particularly in those patients who are seronegative for coeliac disease.
    • Salmi TT, Collin P, Korponay-Szabo IR, et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006; 55:1746-1753. These Finnish authors set out to evaluate the clinical and histological features of EMA-negative coeliac disease, and to examine whether EMA equivalent autoantibodies against tTG can be seen in the small bowel mucosa when absent in the serum. They concluded that the detection of tTG in small bowel mucosa may be of future use, particularly in those patients who are seronegative for coeliac disease.
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    • Hunt KA, Monsuur AJ, McArdle WL, et al. Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut 2006; 55:969-972. The authors aimed to assess the role in coeliac disease susceptibility of genetic variation in MYO9B, which previous studies have suggested may be a predisposing factor. They concluded that in their UK population genetic variation in MYO9B does not have a major influence on coeliac disease predisposition.
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    • •], showing no association.
    • •], showing no association.
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    • Wapenaar MC, Monsuur AJ, Poell J, et al. The SPINK gene family and celiac disease susceptibility. Immunogenetics 2007; 59:349-357. The Dutch authors aimed to assess the gut mucosal gene expression and genetic association of SPINK 1, 2, 4 and 5 in the Dutch coeliac disease population. The authors of this initial work were unable to find an association with coeliac disease.
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    • + IEL clones isolated from coeliac disease and noncoeliac disease biopsies. In summary, they found that the imbalance between functionally distinct IEL populations that reside in the small intestinal mucosa may play a role in the pathogenesis of coeliac disease.
    • + IEL clones isolated from coeliac disease and noncoeliac disease biopsies. In summary, they found that the imbalance between functionally distinct IEL populations that reside in the small intestinal mucosa may play a role in the pathogenesis of coeliac disease.
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    • Benahmed M, Meresse B, Arnulf B, et al. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 2007; 132:994-1008. This French study was conducted to investigate why the proinflammatory effects of IL-15 cannot efficiently be controlled by transforming growth factor-β in coeliac disease. Their study supplies evidence of the potential role of IL-15 in promoting and sustaining intestinal inflammation in coeliac disease through impairment of transforming growth factor-β signalling.
    • Benahmed M, Meresse B, Arnulf B, et al. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 2007; 132:994-1008. This French study was conducted to investigate why the proinflammatory effects of IL-15 cannot efficiently be controlled by transforming growth factor-β in coeliac disease. Their study supplies evidence of the potential role of IL-15 in promoting and sustaining intestinal inflammation in coeliac disease through impairment of transforming growth factor-β signalling.
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    • Kagnoff MF. Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1. Gastroenterology 2007; 132:1174-1176. This compact report collates and summarizes the collecting body of research showing the pivotal role IL-15 plays in impeding transforming growth factor-β signalling in mucosal T-cells and hence its functional relevance in coeliac disease pathogenesis.
    • Kagnoff MF. Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1. Gastroenterology 2007; 132:1174-1176. This compact report collates and summarizes the collecting body of research showing the pivotal role IL-15 plays in impeding transforming growth factor-β signalling in mucosal T-cells and hence its functional relevance in coeliac disease pathogenesis.
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    • Involvement of macrophage migration inhibitory factor gene in celiac disease susceptibility
    • This short communication from these Spanish authors describes their testing of the influence of two functional MIF promotor variants in coeliac disease susceptibility. Their work produces early evidence for the role of the MIF gene in coeliac disease development
    • Nunez C, Rueda B, Martinez A, et al. Involvement of macrophage migration inhibitory factor gene in celiac disease susceptibility. Genes Immun 2007; 8:168-170. This short communication from these Spanish authors describes their testing of the influence of two functional MIF promotor variants in coeliac disease susceptibility. Their work produces early evidence for the role of the MIF gene in coeliac disease development.
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    • Abel M, Cellier C, Kumar N, et al. Adulthood-onset celiac disease is associated with intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Hum Immunol 2006; 67:612-617. The authors studied 180 unrelated French Caucasian patients. Their results indicate that intercellular adhesion molecule genetic variants may play a role in coeliac disease pathogenesis, but it is a small study.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.