Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure

American Journal of Hypertension

Volumn 21, Issue 3, 2008, Pages 297-302

  Vimaleswaran, Karani S ^a   Franks, Paul W ^a,b   Barroso, Inês ^c   Brage, Soren ^a   Ekelund, Ulf ^a   Wareham, Nicholas J ^a   Loos, Ruth J F ^a  

^a INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED RELAXING FACTOR;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY MASS; CALIBRATION; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENERGY EXPENDITURE; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEART RATE VARIABILITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PRIORITY JOURNAL;

ADULT; AGED; ALLELES; BLOOD PRESSURE; COHORT STUDIES; CROSS-SECTIONAL STUDIES; ENERGY METABOLISM; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HEART RATE; HOMOZYGOTE; HUMANS; HYPERTENSION; LIFE STYLE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES;

EID: 40049098830     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2007.69     Document Type: Article

References (33)

1. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodriguez-Artalejo F, Stegmayr B, Thamm M, Tuomilehto J, Vanuzzo D, Vescio F. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003; 289:2363-2369.
2. Goldberg AP. Aerobic and resistive exercise modify risk factors for coronary heart disease. Med Sci Sports Exerc 1989; 21:669-674.
3. An P, Borecki IB, Rankinen T, Perusse L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Evidence of major genes for exercise heart rate and blood pressure at baseline and in response to 20 weeks of endurance training: the HERITAGE family study. Int J Sports Med 2003; 24:492-498.
4. Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S, Michel T. Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett 1992; 307:287-293.
5. Gamboa A, Shibao C, Diedrich A, Choi L, Pohar B, Jordan J, Paranjape S, Farley G, Biaggioni I. Contribution of endothelial nitric oxide to blood pressure in humans. Hypertension 2007; 49:170-177.
6. Hambrecht R, Adams V, Erbs S, Linke A, Krankel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003; 107:3152-3158.
7. Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A. J Biol Chem 2002; 277:3388-3396.
8. Searles CD. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression. Am J Physiol Cell Physiol 2006; 291:C803-C816.
9. Kimura T, Yokoyama T, Matsumura Y, Yoshiike N, Date C, Muramatsu M, Tanaka H. NOS3 genotype-dependent correlation between blood pressure and physical activity. Hypertension 2003; 41:355-360.
10. Rankinen T, Rice T, Perusse L, Chagnon YC, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study. Hypertension 2000; 36:885-889.
11. Forouhi NG, Luan J, Hennings S, Wareham NJ. Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: The Ely study 1990-2000. Diabet Med 2007; 24:200-207.
12. Franks PW, Bhattacharyya S, Luan J, Montague C, Brennand J, Challis B, Brage S, Ekelund U, Middelberg RP, O'Rahilly S, Wareham NJ. Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10. Hypertension 2004; 43:224-228.
13. Wareham NJ, Byrne CD, Williams R, Day NE, Hales CN. Fasting proinsulin concentrations predict the development of type 2 diabetes. Diabetes Care 1999; 22:262-270.
14. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42:1206-1252.
15. Sun SS, Chumlea WC, Heymsfield SB, Lukaski HC, Schoeller D, Friedl K, Kuczmarski RJ, Flegal KM, Johnson CL, Hubbard VS. Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys. Am J Clin Nutr 2003; 77:331-340.
16. Livingstone MB, Prentice AM, Coward WA, Ceesay SM, Strain JJ, McKenna PG, Nevin GB, Barker ME, Hickey RJ. Simultaneous measurement of free-living energy expenditure by the doubly labeled water method and heart-rate monitoring. Am J Clin Nutr 1990; 52:59-65.
17. Ekelund U, Brage S, Franks PW, Hennings S, Emms S, Wareham NJ. Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians: the medical research council Ely study. Diabetes Care 2005; 28:1195-1200.
18. Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol 2003; 1: E20. Erratum in: PLoS Biol 2003; 1:445.
19. Franks PW, Luan J, Barroso I, Brage S, Gonzalez Sanchez JL, Ekelund U, Rios MS, Schafer AJ, O'Rahilly S, Wareham NJ. Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance. Diabetes 2005; 54:2795-2801.
20. International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437:1299-1320.
21. Halbert JA, Silagy CA, Finucane P, Withers RT, Hamdorf PA, Andrews GR. The effectiveness of exercise training in lowering blood pressure: a meta-analysis of randomised controlled trials of 4 weeks or longer. J Hum Hypertens 1997; 11:641-649.
22. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med 2002; 136:493-503.
23. Bonnardeaux A, Nadaud S, Charru A, Jeunemaitre X, Corvol P, Soubrier F. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation 1995; 91:96-102.
24. Hunt SC, Williams CS, Sharma AM, Inoue I, Williams RR, Lalouel JM. Lack of linkage between the endothelial nitric oxide synthase gene and hypertension. J Hum Hypertens 1996; 10:27-30.
25. Miyamoto Y, Saito Y, Kajiyama N, Yoshimura M, Shimasaki Y, Nakayama M, Kamitani S, Harada M, Ishikawa M, Kuwahara K, Ogawa E, Hamanaka I, Takahashi N, Kaneshige T, Teraoka H, Akamizu T, Azuma N, Yoshimasa Y, Yoshimasa T, Itoh H, Masuda I, Yasue H, Nakao K. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 1998; 32:3-8.
26. Moe KT, Lim ST, Wong P, Chua T, Desilva DA, Koh TH, Wong MC, Chin-Dusting J. Association analysis of endothelial nitric oxide synthase gene polymorphism with primary hypertension in a Singapore population. J Hum Hypertens 2006; 20:956-963.
27. Kim IJ, Bae J, Lim SW, Cha DH, Cho HJ, Kim S, Yang DH, Hwang SG, Oh D, Kim NK. Influence of endothelial nitric oxide synthase gene polymorphisms (-786T>C, 4a4b, 894G>T) in Korean patients with coronary artery disease. Thromb Res 2007; 119:579-585.
28. Zhao Q, Su SY, Chen SF, Li B, Gu DF. Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han Chinese. Chin Med J (Engl) 2006; 119:1065-1071.
29. Granath B, Taylor RR, van Bockxmeer FM, Mamotte CD. Lack of evidence for association between endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in the Australian Caucasian population. J Cardiovasc Risk 2001; 8:235-241.
30. Pagenstecher C, Wehner M, Friedl W, Rahner N, Aretz S, Friedrichs N, Sengteller M, Henn W, Buettner R, Propping P, Mangold E. Aberrant splicing in MLH1 and MSH2 due to exonic and intronic variants. Hum Genet 2006; 119:9-22.
31. Li J, Takaishi K, Cook W, McCorkle SK, Unger RH. Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes. Proc Natl Acad Sci USA 2003; 100:9476-9481.
32. Li WD, Dong C, Li D, Garrigan C, Price RA. A genome scan for serum triglyceride in obese nuclear families. J Lipid Res 2005; 46:432-438.
33. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-678.