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Volumn 64, Issue 4, 2008, Pages 335-336

Optimizing efavirenz treatment: CYP2B6 genotyping or therapeutic drug monitoring?

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; CYTOCHROME P450 2B6; EFAVIRENZ;

EID: 40049094339     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-007-0440-z     Document Type: Note
Times cited : (26)

References (15)
  • 1
    • 0032727054 scopus 로고    scopus 로고
    • Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450
    • Erickson DA, Mather G, Trager WF, Levy RH, Keirns JJ (1999) Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos 27:1488-1495
    • (1999) Drug Metab Dispos , vol.27 , pp. 1488-1495
    • Erickson, D.A.1    Mather, G.2    Trager, W.F.3    Levy, R.H.4    Keirns, J.J.5
  • 2
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z (2003) The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 306:287-300
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3    Hall, S.D.4    Flockhart, D.A.5    Desta, Z.6
  • 3
    • 0030739223 scopus 로고    scopus 로고
    • Human cytochrome P4502B6: Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation
    • Code EL, Crespi CL, Penman BW, Gonzalez FJ, Chang TK, Waxman DJ (1997) Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. Drug Metab Dispos 25:985-993
    • (1997) Drug Metab Dispos , vol.25 , pp. 985-993
    • Code, E.L.1    Crespi, C.L.2    Penman, B.W.3    Gonzalez, F.J.4    Chang, T.K.5    Waxman, D.J.6
  • 6
    • 0035875828 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T (2001) Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 15:71-75
    • (2001) AIDS , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 15
    • 40049092364 scopus 로고    scopus 로고
    • High prevelance of the CYP2B651G → T (*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zinbabwe
    • in press
    • Nyakutira C, Röshammar D, Chigutsa E, Chonzi P, Ashton M, Nhachi C, Masimirembwa C (2008) High prevelance of the CYP2B651G → T (*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zinbabwe. Eur J Clin Pharmacol in press
    • (2008) Eur J Clin Pharmacol
    • Nyakutira, C.1    Röshammar, D.2    Chigutsa, E.3    Chonzi, P.4    Ashton, M.5    Nhachi, C.6    Masimirembwa, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.