Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS

Toxicology and Applied Pharmacology

Volumn 227, Issue 3, 2008, Pages 477-484

  Smialowicz, R J ^a   DeVito, M J ^a   Williams, W C ^a   Birnbaum, L S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Antibody response; Immunotoxicity; Mouse; PCB; PCDF; PFC; Relative potency; TCDD

Indexed keywords

1,2,3,4,6,7,8,9 OCTACHLORODIBENZOFURAN; 1,2,3,7,8 PENTACHLORODIBENZO 4 DIOXIN; 1,2,3,7,8 PENTACHLORODIBENZOFURAN; 2,3',4,4',5 PENTACHLOROBIPHENYL; 2,3,3',4,4' PENTACHLOROBIPHENYL; 2,3,3',4,4',5 HEXACHLOROBIPHENYL; 2,3,4,7,8 PENTACHLORODIBENZOFURAN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLORODIBENZOFURAN; 3,3',4,4' TETRACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; 3,3',4,4',5,5N HEXACHLOROBIPHENYL; ANTIBODY; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DIOXIN; LIVER ENZYME; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZO 4 DIOXIN; POLYCHLORINATED DIBENZOFURAN; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BODY WEIGHT; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EXPOSURE; DRUG MIXTURE; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INDUCTION; FEEDING; FEMALE; FOOD; HUMAN; HUMAN TISSUE; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTOXICITY; LIVER; LIVER WEIGHT; LUNG; METHODOLOGY; MOUSE; NONHUMAN; PREDICTION; SHEEP ERYTHROCYTE; SKIN; SPLEEN; THYMUS;

MUS; OVIS ARIES;

EID: 40049087850     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.11.018     Document Type: Article

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