Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine

Biochemical and Biophysical Research Communications

Volumn 368, Issue 4, 2008, Pages 937-941

  Erdmann, Kati ^a   Cheung, Belinda W Y ^a   Immenschuh, Stephan ^b   Schröder, Henning ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Antioxidant; Endothelial cells; Ferritin; Heme oxygenase 1; S Adenosylmethionine

Indexed keywords

ANTIOXIDANT; FERRITIN; HEME OXYGENASE 1; MESSENGER RNA; OXYGEN RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; S ADENOSYLMETHIONINE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME INDUCTION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANTIOXIDANTS; CELL LINE; ENDOTHELIAL CELLS; ENZYME INDUCTION; FERRITINS; HEME OXYGENASE-1; HUMANS; NADP; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; S-ADENOSYLMETHIONINE; UMBILICAL CORD; UP-REGULATION;

EID: 40049086087     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.009     Document Type: Article

References (25)

1. Ames B.N., Shigenaga M.K., and Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90 (1993) 7915-7922
2. McGeer P.L., and McGeer E.G. Inflammation and the degenerative diseases of aging. Ann. N. Y. Acad. Sci. 1035 (2004) 104-116
3. Mato J.M., Alvarez L., Ortiz P., and Pajares M.A. S-Adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol. Ther. 73 (1997) 265-280
4. Caro A.A., and Cederbaum A.I. Antioxidant properties of S-adenosyl-l-methionine in Fe(2+)-initiated oxidations. Free Radic. Biol. Med. 36 (2004) 1303-1316
5. Evans P.J., Whiteman M., Tredger J.M., and Halliwell B. Antioxidant properties of S-adenosyl-l-methionine: a proposed addition to organ storage fluids. Free Radic. Biol. Med. 23 (1997) 1002-1008
6. Lieber C.S. Role of S-adenosyl-l-methionine in the treatment of liver diseases. J. Hepatol. 30 (1999) 1155-1159
7. Soeken K.L., Lee W.L., Bausell R.B., Agelli M., and Berman B.M. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. J. Fam. Pract. 51 (2002) 425-430
8. Mato J.M., Camara J., Fernandez de Paz J., Caballeria L., Coll S., Caballero A., Garcia-Buey L., Beltran J., Benita V., Caballeria J., Sola R., Moreno-Otero R., Barrao F., Martin-Duce A., Correa J.A., Pares A., Barrao E., Garcia-Magaz I., Puerta J.L., Moreno J., Boissard G., Ortiz P., and Rodes J. S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J. Hepatol. 30 (1999) 1081-1089
9. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opin. Investig. Drugs 6 (1997) 417-426
10. Morrison L.D., Smith D.D., and Kish S.J. Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. J. Neurochem. 67 (1996) 1328-1331
11. Gutierrez-Cabano C.A. Probable role of both sulfhydryls and prostaglandins in gastric mucosal protection induced by S-adenosylmethionine. Scand. J. Gastroenterol. 24 (1989) 982-986
12. Bottiglieri T. S-Adenosyl-l-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule. Am. J. Clin. Nutr. 76 (2002) 1151S-1157S
13. Ryter S.W., Alam J., and Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86 (2006) 583-650
14. Takahashi T., Shimizu H., Morimatsu H., Inoue K., Akagi R., Morita K., and Sassa S. Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. Mini Rev. Med. Chem. 7 (2007) 745-753
15. Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., and Ames B.N. Bilirubin is an antioxidant of possible physiological importance. Science 235 (1987) 1043-1046
16. Eisenstein R.S., Garcia-Mayol D., Pettingell W., and Munro H.N. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc. Natl. Acad. Sci. USA 88 (1991) 688-692
17. Juckett M.B., Balla J., Balla G., Jessurun J., Jacob H.S., and Vercellotti G.M. Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. Am. J. Pathol. 147 (1995) 782-789
18. Keyse S.M., and Tyrrell R.M. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. USA 86 (1989) 99-103
19. Suda K., Rothen-Rutishauser B., Gunthert M., and Wunderli-Allenspach H. Phenotypic characterization of human umbilical vein endothelial (ECV304) and urinary carcinoma (T24) cells: endothelial versus epithelial features. In Vitro Cell Dev. Biol. Anim. 37 (2001) 505-514
20. Tamilarasan K.P., Kolluru G.K., Rajaram M., Indhumathy M., Saranya R., and Chatterjee S. Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells. BMC Cell Biol. 7 (2006) 17
21. Grosser N., Hemmerle A., Berndt G., Erdmann K., Hinkelmann U., Schurger S., Wijayanti N., Immenschuh S., and Schroder H. The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. Free Radic. Biol. Med. 37 (2004) 2064-2071
22. Kronke G., Bochkov V.N., Huber J., Gruber F., Bluml S., Furnkranz A., Kadl A., Binder B.R., and Leitinger N. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J. Biol. Chem. 278 (2003) 51006-51014
23. Grosser N., Abate A., Oberle S., Vreman H.J., Dennery P.A., Becker J.C., Pohle T., Seidman D.S., and Schroder H. Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. Biochem. Biophys. Res. Commun. 308 (2003) 956-960
24. Appleton S.D., Chretien M.L., McLaughlin B.E., Vreman H.J., Stevenson D.K., Brien J.F., Nakatsu K., Maurice D.H., and Marks G.S. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab. Dispos. 27 (1999) 1214-1219
25. Erdmann K., Grosser N., Schipporeit K., and Schroder H. The ACE inhibitory dipeptide Met-Tyr diminishes free radical formation in human endothelial cells via induction of heme oxygenase-1 and ferritin. J. Nutr. 136 (2006) 2148-2152