Neurovirulent factor ICP34.5 uniquely expressed in the herpes simplex virus type 1δγ134.5 mutant 1716

Journal of NeuroVirology

Volumn 14, Issue 1, 2008, Pages 28-40

  Holman, Holly A ^a   MacLean, Alasdair R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

1716; Genetherapy; Herpes simplex virus; ICP34.5; Neurovirulence

Indexed keywords

INFECTED CELL PROTEIN 34.5; ONCOLYTIC VIRUS; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIPLOIDY; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; LATENT VIRUS INFECTION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; ONCOLYTIC VIROTHERAPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; VIRAL GENE DELIVERY SYSTEM; VIRUS GENOME; VIRUS PLAQUE; VIRUS REACTIVATION; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; WILD TYPE;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 39849097517     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280701769999     Document Type: Article

References (34)

1. M Ackermann J Chou M Sarmiento RA Lerner B Roizman 1986 Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome J Virol 58 843 850 1:CAS:528:DyaL28Xktl2isbw%3D 3009891 Ackermann M, Chou J, Sarmiento M, Lerner RA, Roizman B (1986). Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome. J Virol 58: 843–850.
2. TL Black GN Barber MG Katze 1993 Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA J Virol 67 791 800 1:CAS:528:DyaK3sXhsVCktbg%3D 7678306 Black TL, Barber GN, Katze MG (1993). Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA. J Virol 67: 791–800.
3. CA Bolovan NM Sawtell RL Thompson 1994 ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures J Virol 68 48 55 1:CAS:528:DyaK2cXht12gtro%3D 8254758 Bolovan CA, Sawtell NM, Thompson RL (1994). ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. J Virol 68: 48–55.
4. SM Brown J Harland AR MacLean J Podlech JB Clements 1994 Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2 J Gen Virol 75 2367 2377 1:CAS:528:DyaK2cXlslKnurY%3D 10.1099/0022-1317-75-9-2367 8077935 Brown SM, Harland J, MacLean AR, Podlech J, Clements JB (1994). Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2. J Gen Virol 75 (Pt 9): 2367–2377.
5. SM Brown AR MacLean EA McKie J Harland 1997 The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34 J Virol 71 9442 9449 1:CAS:528:DyaK2sXnsVCrs7s%3D 9371605 Brown SM, MacLean AR, McKie EA, Harland J (1997). The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34. J Virol 71: 9442–9449.
6. K Carroll O Elroy-Stein B Moss R Jagus 1993 Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase J Biol Chem 268 12837 12842 1:CAS:528:DyaK3sXltlCis7k%3D 8099586 Carroll K, Elroy-Stein O, Moss B, Jagus R (1993). Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase. J Biol Chem 268: 12837–12842.
7. J Chou ER Kern RJ Whitley B Roizman 1990 Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture Science 250 1262 1266 1:CAS:528:DyaK3MXjs1OrsQ%3D%3D 10.1126/science.2173860 2173860 Chou J, Kern ER, Whitley RJ, Roizman B (1990). Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. Science 250: 1262–1266.
8. J Chou B Roizman 1986 The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component J Virol 57 629 637 1:CAS:528:DyaL28Xht1equro%3D 3003394 Chou J, Roizman B (1986). The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component. J Virol 57: 629–637.
9. J Chou B Roizman 1992 The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells Proc Natl Acad Sci U S A 89 3266 3270 1:CAS:528:DyaK38XisFehsbc%3D 10.1073/pnas.89.8.3266 1314384 Chou J, Roizman B (1992). The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. Proc Natl Acad Sci U S A 89: 3266–3270.
10. RY Chung Y Saeki EA Chiocca 1999 B-myb promoter retargeting of herpes simplex virus gamma34.5 genemediated virulence toward tumor and cycling cells J Virol 73 7556 7564 1:CAS:528:DyaK1MXltlKhtL4%3D 10438845 Chung RY, Saeki Y, Chiocca EA (1999). B-myb promoter retargeting of herpes simplex virus gamma34.5 genemediated virulence toward tumor and cycling cells. J Virol 73: 7556–7564.
11. MV Davies HW Chang BL Jacobs RJ Kaufman 1993 The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms J Virol 67 1688 1692 1:CAS:528:DyaK3sXhs1agur8%3D 8094759 Davies MV, Chang HW, Jacobs BL, Kaufman RJ (1993). The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms. J Virol 67: 1688–1692.
12. B He J Chou DA Liebermann B Hoffman B Roizman 1996 The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells J Virol 70 84 90 1:CAS:528:DyaK2MXpvFSnurs%3D 8523596 He B, Chou J, Liebermann DA, Hoffman B, Roizman B (1996). The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells. J Virol 70: 84–90.
13. B He M Gross B Roizman 1997 The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by doublestranded RNA-activated protein kinase Proc Natl Acad Sci U S A 94 843 848 1:CAS:528:DyaK2sXhtVOlt7s%3D 10.1073/pnas.94.3.843 9023344 He B, Gross M, Roizman B (1997). The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by doublestranded RNA-activated protein kinase. Proc Natl Acad Sci U S A 94: 843–848.
14. X Jing B He 2005 Characterization ofthe triplet repeats in the central domain of the gamma134.5 protein of herpes simplex virus 1 J Gen Virol 86 2411 2419 1:CAS:528:DC%2BD2MXps1Ogtb0%3D 10.1099/vir.0.81033-0 16099898 Jing X, He B (2005). Characterization ofthe triplet repeats in the central domain of the gamma134.5 protein of herpes simplex virus 1. J Gen Virol 86: 2411–2419.
15. MG Katze 1995 Regulation of the interferon-induced PKR: can viruses cope? Trends Microbiol 3 75 78 1:STN:280:DyaK2M3ksFKjtA%3D%3D 10.1016/S0966-842X(00)88880-0 7537157 Katze MG (1995). Regulation of the interferon-induced PKR: can viruses cope? Trends Microbiol 3: 75–78.
16. TG Lee N Tang S Thompson J Miller MG Katze 1994 The 58,000-dalton cellular inhibitor of the interferoninduced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins Mol Cell Biol 14 2331 2342 1:CAS:528:DyaK2cXktVertr8%3D 7511204 Lee TG, Tang N, Thompson S, Miller J, Katze MG (1994). The 58,000-dalton cellular inhibitor of the interferoninduced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. Mol Cell Biol 14: 2331–2342.
17. Y Lu M Wambach MG Katze RM Krug 1995 Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor Virology 214 222 228 1:CAS:528:DyaK2MXpslOmtb4%3D 10.1006/viro.1995.9937 8525619 Lu Y, Wambach M, Katze MG, Krug RM (1995). Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology 214: 222–228.
18. AR MacLean M ul-Fareed L Robertson J Harland SM Brown 1991 Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the ‘a’ sequence J Gen Virol 72 631 639 1:CAS:528:DyaK3MXitVSlsr8%3D 10.1099/0022-1317-72-3-631 1848598 MacLean AR, ul-Fareed M, Robertson L, Harland J, Brown SM (1991a). Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the ‘a’ sequence. J Gen Virol 72 (Pt 3): 631–639.
19. CA MacLean S Efstathiou ML Elliott FE Jamieson DJ McGeoch 1991 Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins J Gen Virol 72 897 906 1:CAS:528:DyaK3MXisVWmtr8%3D 10.1099/0022-1317-72-4-897 1849972 MacLean CA, Efstathiou S, Elliott ML, Jamieson FE, McGeoch DJ (1991b). Investigation of herpes simplex virus type 1 genes encoding multiply inserted membrane proteins. J Gen Virol 72 (Pt 4): 897–906.
20. H Mao KS Rosenthal 2003 Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential J Virol 77 3409 3417 1:CAS:528:DC%2BD3sXhvFyquro%3D 10.1128/JVI.77.6.3409-3417.2003 12610116 Mao H, Rosenthal KS (2003). Strain-dependent structural variants of herpes simplex virus type 1 ICP34.5 determine viral plaque size, efficiency of glycoprotein processing, and viral release and neuroinvasive disease potential. J Virol 77: 3409–3417.
21. JM Markert MD Medlock SD Rabkin GY Gillespie T Todo WD Hunter CA Palmer F Feigenbaum C Tornatore F Tufaro RL Martuza 2000 Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial Gene Ther 7 867 874 1:CAS:528:DC%2BD3cXjsVKju7Y%3D 10.1038/sj.gt.3301205 10845725 Markert JM, Medlock MD, Rabkin SD, Gillespie GY, Todo T, Hunter WD, Palmer CA, Feigenbaum F, Tornatore C, Tufaro F, Martuza RL (2000). Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther 7: 867–874.
22. MB Mathews T Shenk 1991 Adenovirus virus-associated RNA and translation control J Virol 65 5657 5662 1:CAS:528:DyaK38Xhslagtg%3D%3D 1920611 Mathews MB, Shenk T(1991). Adenovirus virus-associated RNA and translation control. J Virol 65: 5657–5662.
23. DJ McGeoch BC Barnett 1991 Neurovirulence factor Nature 353 609 609 1:STN:280:DyaK38%2FhvVantg%3D%3D 10.1038/353609b0 1656275 McGeoch DJ, Barnett BC (1991). Neurovirulence factor. Nature 353: 609.
24. A McGregor A Roberts RW Davies JB Clements AR MacLean 1999 Rapid generation of recombinant herpes simplex virus vectors expressing bacterial lacZ gene undercontrol of neuronal promoters Gene Ther Mol Biol 4 193 202 McGregor A, Roberts A, Davies RW, Clements JB, MacLean AR (1999). Rapid generation of recombinant herpes simplex virus vectors expressing bacterial lacZ gene undercontrol of neuronal promoters. Gene Ther Mol Biol 4: 193–202.
25. EM McKay B McVey HS Marsden SM Brown AR MacLean 1993 The herpes simplex virus type 1 strain 17 open reading frame RL1 encodes a polypeptide of apparent M(r) 37K equivalent to ICP34.5 of herpes simplex virus type 1 strain F J Gen Virol 74 2493 2497 1:CAS:528:DyaK2cXkvFOhtQ%3D%3D 10.1099/0022-1317-74-11-2493 8245868 McKay EM, McVey B, Marsden HS, Brown SM, MacLean AR (1993). The herpes simplex virus type 1 strain 17 open reading frame RL1 encodes a polypeptide of apparent M(r) 37K equivalent to ICP34.5 of herpes simplex virus type 1 strain F. J Gen Virol 74 (Pt 11): 2493–2497.
26. EA McKie SM Brown AR MacLean DI Graham 1998 Histopathological responses in the CNS following inoculation with a non-neurovirulent mutant (1716) of herpes simplex virus type 1 (HSV 1): relevance for gene and cancer therapy Neuropathol Appl Neurobiol 24 367 372 1:STN:280:DyaK1M%2FjvVKjug%3D%3D 10.1046/j.1365-2990.1998.00133.x 9821167 McKie EA, Brown SM, MacLean AR, Graham DI (1998a). Histopathological responses in the CNS following inoculation with a non-neurovirulent mutant (1716) of herpes simplex virus type 1 (HSV 1): relevance for gene and cancer therapy. Neuropathol Appl Neurobiol 24: 367–372.
27. EA McKie DI Graham SM Brown 1998 Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vectorpotential glioblastoma targeting Gene Ther 5 440 450 1:CAS:528:DyaK1cXis1eqtro%3D 10.1038/sj.gt.3300621 9614567 McKie EA, Graham DI, Brown SM (1998b). Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vectorpotential glioblastoma targeting. Gene Ther 5: 440–450.
28. EA McKie RG Hope SM Brown AR MacLean 1994 Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system J Gen Virol 75 733 741 1:CAS:528:DyaK2cXis1GntLw%3D 10.1099/0022-1317-75-4-733 8151292 McKie EA, Hope RG, Brown SM, MacLean AR (1994). Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system. J Gen Virol 75 (Pt 4): 733–741.
29. EA McKie AR MacLean AD Lewis G Cruickshank R Rampling SC Barnett PG Kennedy SM Brown 1996 Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours—evaluation of a potentially effective clinical therapy Br J Cancer 74 745 752 1:STN:280:DyaK28zovVWktA%3D%3D 10.1038/bjc.1996.431 8795577 McKie EA, MacLean AR, Lewis AD, Cruickshank G, Rampling R, Barnett SC, Kennedy PG, Brown SM (1996). Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours—evaluation of a potentially effective clinical therapy. Br J Cancer 74: 745–752.
30. I Mohr Y Gluzman 1996 A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function EMBO J 15 4759 4766 1:CAS:528:DyaK28XlvV2htrw%3D 8887567 Mohr I, Gluzman Y (1996). A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function. EMBO J 15: 4759–4766.
31. R Rampling G Cruickshank V Papanastassiou J Nicoll D Hadley D Brennan R Petty A MacLean J Harland E McKie R Mabbs M Brown 2000 Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma Gene Ther 7 859 866 1:CAS:528:DC%2BD3cXjsVKju7k%3D 10.1038/sj.gt.3301184 10845724 Rampling R, Cruickshank G, Papanastassiou V, Nicoll J, Hadley D, Brennan D, Petty R, MacLean A, Harland J, McKie E, Mabbs R, Brown M (2000). Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther 7: 859–866.
32. NM Sawtell 2003 Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation J Virol 77 4127 4138 1:CAS:528:DC%2BD3sXisVKrsro%3D 10.1128/JVI.77.7.4127-4138.2003 12634371 Sawtell NM (2003). Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation. J Virol 77: 4127–4138.
33. RL Thompson EK Wagner JG Stevens 1983 Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence Virology 131 180 192 1:CAS:528:DyaL2cXjtVemsw%3D%3D 10.1016/0042-6822(83)90544-5 6316650 Thompson RL, Wagner EK, Stevens JG (1983). Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence. Virology 131: 180–192.
34. SL Ward D Scheuner J Poppers RJ Kaufman I Mohr DA Leib 2003 In vivo replication of an ICP34.5 secondsite suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation J Virol 77 4626 4634 1:CAS:528:DC%2BD3sXivFWisLw%3D 10.1128/JVI.77.8.4626-4634.2003 12663769 Ward SL, Scheuner D, Poppers J, Kaufman RJ, Mohr I, Leib DA (2003). In vivo replication of an ICP34.5 secondsite suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation. J Virol 77: 4626–4634.