The effects of mercury on muscarinic cholinergic receptor subtypes (M1 and M2) in captive mink

NeuroToxicology

Volumn 29, Issue 2, 2008, Pages 328-334

  Basu, Niladri ^a,b   Scheuhammer, Anton M ^b   Rouvinen Watt, Kirsti ^c   Evans, R Douglas ^d   Grochowina, Nicole ^d   Chan, Laurie H M ^e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ENVIRONMENT CANADA   (Canada)

^c DALHOUSIE UNIVERSITY   (Canada)

^d TRENT UNIVERSITY   (Canada)

^e UNIVERSITY OF NORTHERN BRITISH COLUMBIA   (Canada)

Author keywords

Mercury; Muscarinic cholinergic receptors; Neurotoxicology; Wildlife

Indexed keywords

MERCURIC CHLORIDE; METHYLMERCURY; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; N [2 [2 (DIPROPYLAMINOMETHYL) 1 PIPERIDYL]ETHYL] 5,11 DIHYDRO 6 OXO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPINE 11 CARBOXAMIDE; RADIOLIGAND;

ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BRAIN STEM; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; MINK; MUSTELA VISON; NONHUMAN; OCCIPITAL CORTEX; PRIORITY JOURNAL;

ANIMALS; BINDING, COMPETITIVE; BRAIN STEM; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FOOD CONTAMINATION; MALE; METHYLMERCURY COMPOUNDS; MINK; MUSCARINIC ANTAGONISTS; OCCIPITAL LOBE; PIRENZEPINE; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; TRITIUM;

ANIMALIA; MUSTELA; MUSTELA VISON; RODENTIA;

EID: 39749160935     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.01.003     Document Type: Article

References (30)

1. Abd-Elfattah A.S., and Shamoo A.E. Regeneration of a functionally active rat brain muscarinic receptor by d-penicillamine after inhibition with methylmercury and mercuric chloride. Mol Pharmacol 20 (1981) 492-497
2. Basu N., Stamler C.J., Loua K.M., and Chan H.M. An inter-species comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum. Toxicol Appl Pharmacol 205 (2005) 71-76
3. Basu N., Klenavic K., Gamberg M., O'Brien M., Evans R.D., Scheuhammer A.M., et al. Effects of mercury on neurochemical receptor binding characteristics in wild mink. Environ Toxicol Chem 24 (2005) 1444-1450
4. Basu N., Scheuhammer A.M., Grochowina N.M., Klenavic K., Evans R.D., O'Brien M., et al. Effects of mercury on neurochemical receptors in wild river otters (Lontra canadensis). Environ Sci Technol 39 (2005) 3585-3591
5. Basu N., Scheuhammer A.M., Rouvinen-Watt K., Grochowina N., Klenavic K., Evans R.D., et al. Methylmercury impairs components of the cholinergic system in captive mink (Mustela vison). Toxicol Sci 91 (2006) 202-209
6. Basu N., Scheuhammer A.M., Bursian S.J., Elliott J., Rouvinen-Watt K., and Chan H.M. Mink as a sentinel species in environmental health. Environ Res 103 (2007) 130-144
7. Basu N., Scheuhammer A.M., Rouvinen-Watt K., Grochowina N., Evans R.D., O'Brien M., et al. Decreased N-methyl-d-aspartic acid (NMDA) receptor levels are associated with mercury exposure in wild and captive mink. Neurotoxicology 28 (2007) 587-593
8. Bondy S.C., and Agrawal A.K. The inhibition of cerebral high affinity receptor sites by lead and mercury compounds. Arch Toxicol 46 (1980) 249-256
9. Burbacher T.M., Rodier P.M., and Weiss B. Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals. Neurotoxicol Teratol 12 (1990) 191-202
10. Bymaster F.P., McKinzie D.L., Felder C.C., and Wess J. Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res 28 (2003) 437-442
11. Castoldi A.F., Candura S.M., Costa P., Manzo L., and Costa L.G. Interaction of mercury compounds with muscarinic receptor subtypes in the rat brain. Neurotoxicology 17 (1996) 735-741
12. Clarkson T.W., and Magos L. The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36 (2006) 609-662
13. Coccini T., Randine G., Candura S.M., Nappi R.E., Prockop L.D., and Manzo L. Low-level exposure to methylmercury modifies muscarinic cholinergic receptor binding characteristics in rat brain and lymphocytes: physiologic implications and new opportunities in biologic monitoring. Environ Health Perspect 108 (2000) 29-33
14. Coccini T., Randine G., Castoldi A.F., Grandjean P., Ostendorp G., Heinzow B., et al. Effects of developmental co-exposure to methylmercury and 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB153) on cholinergic muscarinic receptors in rat brain. Neurotoxicology 27 (2006) 468-477
15. Eldefrawi M.E., Mansour N.A., and Eldefrawi A.T. Interactions of acetylcholine receptors with organic mercury compounds. Adv Exp Med Biol 84 (1977) 449-463
16. Kobayashi H., Yuyama A., Matsusaka N., Takeno K., and Yanagiya I. Neuropharmacological effect of methylmercury in mice with special reference to the central cholinergic system. Jpn J Pharmacol 31 (1981) 711-718
17. 2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway. Toxicol Sci 80 (2004) 60-68
18. Meacham C.A., Freudenrich T.M., Anderson W.L., Sui L., Lyons-Darden T., Barone J.S., et al. Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue. Toxicol Appl Pharmacol 205 (2005) 177-187
19. Scheuhammer A.M., Meyer M.W., Sandheinrich M.B., and Murray M.W. Effects of environmental methylmercury on the health of wild birds, mammals, and fish. Ambio 36 (2007) 12-18
20. Scheuhammer A.M., Basu N., Burgess N., Elliott J.E., Campbell G.D., Wayland M., et al. Relationships among mercury, selenium, and neurochemical parameters in common loons (Gavia immer) and bald eagles (Haliaeetus leucocephalus). Ecotoxicology 17 (2008) 93-101
21. Sirois J.E. Atchison WD Effects of mercurials on ligand- and voltage-gated ion channels: a review. Neurotoxicology 17 (1996) 63-84
22. Stamler C.J., Basu N., and Chan H.M. Biochemical markers of neurotoxicity in wildlife and human populations: considerations for method development. J Toxicol Environ Health 68 (2005) 1413-1429
23. Tayebati S.K., Di Tullio M.A., and Amenta F. Muscarinic cholinergic receptor subtypes in cerebral cortex of Fisher 344 rats: a light microscope autoradiography study of age-related changes. Mech Ageing Dev 127 (2006) 115-122
24. Yu C.J., Butt C.M., and Debski E.A. Bidirectional modulation of visual plasticity by cholinergic receptor subtypes in the frog optic tectum. Eur J Neurosci 17 (2003) 1253-1265
25. Von Burg R., Northington F.K., and Shamoo A. Methylmercury inhibition of rat brain muscarinic receptors. Toxicol Appl Pharmacol 53 (1980) 285-292
26. Wall S.J., Yasuda R.P., Li M., Ciesla W., and Wolfe B.B. Differential regulation of subtypes M1-M5 of muscarinic receptors in forebrain by chronic atropine administration. J Pharmacol Exp Ther 262 (1992) 584-588
27. Wess J. Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 10 (1996) 69-99
28. Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu Rev Pharmacol Toxicol 44 (2004) 423-450
29. Wobeser G., Nielsen N.O., and Schiefer B. Mercury and mink. II. Experimental methyl mercury intoxication. Can J Comp Med 40 (1976) 34-45
30. Zanoli P., Truzzi C., Veneri C., Braghiroli D., and Baraldi M. Methyl mercury during late gestation affects temporarily the development of cortical muscarinic receptors in rat offspring. Pharmacol Toxicol 75 (1994) 261-264