Effect of a novel partial adenosine A1 receptor agonist VCP102 in reducing ischemic damage in the mouse heart

Drug Development Research

Volumn 68, Issue 8, 2007, Pages 529-537

  Butcher, Anna ^a   Gregg, Alison ^b   Scammells, Peter J ^b   Meyer, Roselyn B Rose' ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Adenosine receptor agonist; Heart; Ischemia; VCP102

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR AGONIST; PARTIAL AGONIST; UNCLASSIFIED DRUG; VCP 102;

ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; MALE; MOUSE; NONHUMAN;

EID: 39749131172     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20220     Document Type: Article

References (22)

1. Buja LM. 2005. Myocardial ischemia and reperfusion injury. Cardiovasc Pathol 14: 170–175.
2. Bunemann M, Lee KB, Pals‐Rylaarsdam R, Roseberry AG, Hosey MM. 1999. Desensitisation of G‐protein coupled receptors in the cardiovascular system. Annu Rev Physiol 61: 169–192.
3. Cohen MV, Downey JM. 2006. AMISTAD trials: possible reasons for lack of success. J Am Coll Cardiol 47: 1236.
4. Dana A, Baxter GF, Walker JM, Yellon DM. 1998. Prolonging the delayed phase of myocardial protection: repetitive adenosine A 1 receptor activation maintains rabbit myocardium in a preconditioned state. J Am Coll Cardiol 31: 1142–1149.
5. Das S, Cordis GA, Maulik N, Das DK. 2005. Pharmacological preconditioning with resveratrol: role of CREB‐dependent Bcl‐2 signaling via adenosine A 3 receptor activation. Am J Physiol (Heart Circ Physiol) 288: H328–H335.
6. Dhalla AK, Shryock JC, Shreeniwas R, Belardinelli L. 2003. Pharmacology and therapeutic applications of A 1 adenosine receptor ligands. Curr Top Med Chem 3: 369–385.
7. Gregg A, Bottle SE, Devine SM, Figler H, Linden J, White P, Pouton CW, Urmaliya V, Scammells PJ. 2007. Dual acting antioxidant A 1 adenosine receptor agonists. Bioorg Med Chem Lett 17: 5437–5441.
8. Headrick JP, Peart J, Hack B, Matherne GP. 2001. Functional properties and responses to ischaemia‐reperfusion in Langendorff perfused mouse heart. Exp Physiol 86: 703–716.
9. Henry P, Demolombe S, Puceat M, Escande D. 1996. Adenosine A 1 stimulation activates delta‐protein kinase C in rat ventricular myocytes. Circ Res 78: 161–165.
10. Jacobson KA, Gao Z‐G. 2006. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5: 247–264.
11. January B, Seibold A, Whaley B, Hipkin RW, Lin D, Schonbrunn A, Barber R, Clark RB. 1997. beta 2‐Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. J Biol Chem 272: 23871–23879.
12. Kitakaze M, Hori M. 1998. It is time to ask what adenosine can do for cardioprotection. Heart Vessels 13: 211–228.
13. Lankford AR, Byford AM, Ashton KJ, French BA, Lee JK, Headrick JP, Matherne GP. 2002. Gene expression profile of mouse myocardium with transgenic overexpression of A 1 adenosine receptors. Physiol Genom 11: 81–89.
14. Mozzicato S, Joshi BV, Jacobson KA, Liang BT. 2004. Role of direct RhoA‐phospholipase D1 interaction in mediating adenosine‐induced protection from cardiac ischemia. FASEB J 18: 406–408.
15. Mubagwa K, Flameng W. 2001. Adenosine, adenosine receptors and myocardial protection: an updated overview. Cardiovasc Res 52: 25–39.
16. Olah ME, Stiles GL. 1995. Adenosine receptor subtypes: characterisation and therapeutic regulation. Annu Rev Pharmacol Toxicol 35: 581–606.
17. Piper HM, Garcia‐Dorado D, Ovize M. 1998. A fresh look at reperfusion injury. Cardiovasc Res 38: 291–300.
18. Ralevic V, Burnstock G. 1998. Receptors for purines and pyrimidines. Pharmacol Rev 50: 413–492.
19. Regan SE, Broad M, Byford AM, Lankford AR, Cerniway RJ, Mayo MW, Matherne GP. 2003. A 1 adenosine receptor overexpression attenuates ischemia‐reperfusion‐induced apoptosis and caspase 3 activity. Am J Physiol (Heart Circ Physiol) 284: H859–H866.
20. Ross AM, Gibbons R, Stone GW, Kloner RA, Alexander W. 2005. A randomized, double‐blinded, placebo‐controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD‐II). J Am Coll Cardiol 45: 1775–1780.
21. Shryock J, Bellardinelli L. 1997. Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology and pharmacology. Am J Cardiol 79: 2–10.
22. Yan L, Burbiel JC, Maass A, Muller CE. 2003. Adenosine receptor agonists: from basic medicinal chemistry to clinical development. Exp Opinion Emerg Drugs 8: 537–576.