Molecular determinants of Rem2 regulation of N-type calcium channels

Biochemical and Biophysical Research Communications

Volumn 368, Issue 3, 2008, Pages 827-831

  Flynn, Robyn ^a   Chen, Lina ^a   Hameed, Shahid ^a   Spafford, J David ^a   Zamponi, Gerald W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Beta subunit; Calcium channel; GTPase; Rem2; RGK protein

Indexed keywords

CALCIUM CHANNEL N TYPE; COMPLEMENTARY DNA; GUANOSINE TRIPHOSPHATASE; PROTEIN GEM; PROTEIN RAD1; PROTEIN REM; PROTEIN REM2; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

EID: 39749128361     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.020     Document Type: Article

References (20)

1. B.S. Finlin H. Shao K. Kadono-Okuda N. Guo D.A. Andres Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases Biochem. J. 347 Pt. 1 2000 223 231
2. K. Kelly The RGK family: a regulatory tail of small GTP-binding proteins Trends Cell Biol. 15 2005 640 643
3. B.S. Finlin S.M. Crump J. Satin D.A. Andres Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases Proc. Natl. Acad. Sci. USA 100 2003 14469 14474
4. B.S. Finlin A.L. Mosley S.M. Crump R.N. Correll S. Ozcan J. Satin D.A. Andres Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase J. Biol. Chem. 280 2005 41864 41871
5. P. Beguin K. Nagashima T. Gonoi T. Shibasaki K. Takahashi Y. Kashima N. Ozaki K. Geering T. Iwanaga S. Seino Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem Nature 411 2001 701 706
6. P. Beguin R.N. Mahalakshmi K. Nagashima D.H. Cher N. Kuwamura Y. Yamada Y. Seino W. Hunziker Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2 Biochem. J. 390 2005 67 75
7. H. Chen H.L. Puhl S.L. Niu D.C. Mitchell S.R. Ikeda Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density J. Neurosci. 25 2005 9762 9772
8. L. Seu G.S. Pitt Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases J. Gen. Physiol. 128 2006 605 613
9. P. Beguin Y.J. Ng C. Krause R.N. Mahalakshmi M.Y. Ng W. Hunziker RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+channel beta-subunits via an uncommon effector binding domain J. Biol. Chem. 282 2007 11509 11520
10. H. Yada M. Murata K. Shimoda S. Yuasa H. Kawaguchi M. Ieda T. Adachi M. Murata S. Ogawa K. Fukuda Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart Circ. Res. 101 2007 69 77
11. W.D. Heo T. Inoue W.S. Park M.L. Kim B.O. Park T.J. Wandless T. Meyer PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane Science 314 2006 1458 1461
12. R.N. Correll C. Pang B.S. Finlin A.M. Dailey J. Satin D.A. Andres Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition J. Biol. Chem. 282 2007 28431 28440
13. R.N. Correll G.J. Botzet J. Satin D.A. Andres B.S. Finlin Analysis of the Rem2—voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids Cell. Signal. 20 2008 400 408
14. B.S. Finlin R.N. Correll C. Pang S.M. Crump J. Satin D.A. Andres Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase J. Biol. Chem. 281 2006 23557 23566
15. S.C. Stotz W. Barr J.E. McRory L. Chen S.E. Jarvis G.W. Zamponi Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit J. Biol. Chem. 279 2004 3793 3800
16. C. Altier H. Khosravani R.M. Evans S. Hameed J.B. Peloquin B.A. Vartian L. Chen A.M. Beedle S.S. Ferguson A. Mezghrani S.J. Dubel E. Bourinet J.E. McRory G.W. Zamponi ORL1 receptor-mediated internalization of N-type calcium channels Nat. Neurosci. 9 2006 31 40
17. A.M. Beedle J.E. McRory O. Poirot C.J. Doering C. Altier C. Barrere J. Hamid J. Nargeot E. Bourinet G.W. Zamponi Agonist-independent modulation of N-type calcium channels by ORL1 receptors Nat. Neurosci. 7 2004 118 125
18. J. Maguire T. Santoro P. Jensen U. Siebenlist J. Yewdell K. Kelly Gem: an induced, immediate early protein belonging to the Ras family Science 265 1994 241 244
19. M. Pragnell M. De Waard Y. Mori T. Tanabe T.P. Snutch K.P. Campbell Calcium channel beta-subunit binds to a conserved motif in the I–II cytoplasmic linker of the alpha 1-subunit Nature 368 1994 67 70
20. S.C. Stotz S.E. Jarvis G.W. Zamponi Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels J. Physiol. 554 2004 263 273