Setting properties and in vitro bioactivity of strontium-enriched gelatin-calcium phosphate bone cements

Journal of Biomedical Materials Research - Part A

Volumn 84, Issue 4, 2008, Pages 965-972

  Panzavolta, S ^a   Torricelli, P ^b   Sturba, L ^a   Bracci, B ^a   Giardino, R ^a,b   Bigi, A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Bioactivity; Biocompatibility; Calcium phosphate bone cement; In vitro; Strontium

Indexed keywords

BIOACTIVITY; BIOCOMPATIBILITY; BIOMIMETIC MATERIALS; CALCIUM PHOSPHATE; SOLID SOLUTIONS; STRONTIUM COMPOUNDS;

BIOMIMETIC GELATIN; BONE FORMATION; CALCIUM PHOSPHATE BONE CEMENTS;

BONE CEMENT;

BONE CEMENT; CALCIUM PHOSPHATE; GELATIN; HYDROXYAPATITE; STRONTIUM;

ARTICLE; BIOCOMPATIBILITY; BIOMIMETICS; CELL ACTIVITY; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; HUMAN; HUMAN CELL; OSTEOBLAST; POROSITY; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ALKALINE PHOSPHATASE; ANIMALS; BIOCOMPATIBLE MATERIALS; BONE CEMENTS; CALCIUM PHOSPHATES; CELL ADHESION; COLLAGEN TYPE I; GELATIN; HUMANS; OSTEOCALCIN; OSTEOPROTEGERIN; POWDERS; STRONTIUM; SWINE;

EID: 39749125468     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31412     Document Type: Article

References (33)

1. Bonher M. Calcium orthophosphates in medicine: From ceramics to calcium phosphate cements. Injury 2000;31:D37-D47.
2. Fernández E. Bioactive bone cements. In: Metin A, editor. Wiley Encyclopedia of Biomedical Engineering. New York: Wiley; 2006. p 1-9.
3. Fernández E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA, Best SM. Calcium phosphate bone cements for clinical applications. II. Precipitate formation during setting reactions. J Mater Sci Mater Med 1999;10:177-183.
4. Bigi A, Panzavolta S, Rubini K. Setting mechanism of a biomimetic bone cement. Chem Mater 2004;16:3740-3745.
5. Khairoun I, Driessens FCM, Boltong MG, Planell JA. Addition of cohesion promotors to calcium phosphate cements. Biomaterials 1999;20:393-398.
6. Dos Santos LA, De Oliveira LC, Rigo ECS, Carrodeguas RG, Boschi AO, DeArruda ACF. Influence of polymeric additives on the mechanical properties of α-tricalcium phosphate cement. Bone 1999;25:99-102.
7. Driessens FCM, Boltong MC, de Maeyer EAP, Wenz R, Nies B, Planell JA. The Ca/P range of nanoapatitic calcium phosphate cements. Biomaterials 2002;23:4011-4017.
8. Driessens FCM, Boltong MG, De Maeyer EAP, Verbeeck RMH, Wenz R. Effect of temperature and immersion on the setting of some calcium phosphate cements. J Mater Sci Mater Med 2000;11:453-457.
9. Fernandez E, Sarda S, Hamcerencu M, Vlad MD, Gel M, Valls S, Torres R, Lopez J. High-strength apatitic cement by modification with superplasticizers. Biomaterials 2005;26:2289-2296.
10. Bigi A, Bracci B, Panzavolta S. Effect of added gelatin on the properties of calcium phosphate cement. Biomaterials 2004;25:2893-2899.
11. Durucan C, Brown PW. Reactivity of α-tricalcium phosphate. J Mater Sci 2002;37:963-969.
12. Bigi A, Torricelli P, Fini M, Bracci B, Panzavolta S, Sturba L, Giardino R. A biomimetic gelatin-calcium phosphate bone cement. Int J Artif Organs 2004;27:664-673.
13. Bigi A, Panzavolta S, Sturba L, Torricelli P, Fini M, Giardino R. Normal and osteopenic bone-derived osteoblast response to a biomimetic gelatin-calcium phosphate bone cement. J Biomed Mater Res A 2006;78:739-745.
14. Blake GM, Zivanovic MA, Mcewan AJ. Sr-89 therapy: Strontium kinetics in disseminated carcinoma of the prostate. Eur J Nucl Med 1986;12:447-451.
15. Shorr E, Carter AC. The value of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis Orthop Inst 1952;13:59-63.
16. Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 1996;18:517-523.
17. Chang W, Tu C, Chen T, Komuwes L, Oda Y, Pratt S, Miller S, Shoback D. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology 1999;40:5883-5893.
18. Grynpas MD, Hamilton E, Cheung R, Tsouderos Y, Deloffre P, Hott M, Marie PJ. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18:253-259.
19. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 2001;69:121-129.
20. Dahl SG, Allain P, Marie PJ, Mauras Y, Boivin G, Ammann P, Tsouderos Y, Delmas PD, Christiansen C. Incorporation and distribution of strontium in bone. Bone 2001;28:446-453.
21. Bigi A, Boanini E, Botter R, Panzavolta S, Rubini K. α-Tricalcium phosphate hydrolysis to octacalcium phosphate: Effect of sodium polyacrylate. Biomaterials 2002;23:1849-1854.
22. Barralet JE, Gaunt T, Wright AJ, Gibson IR, Knowles JC. Effect of porosity reduction by compaction on compressive strength and microstructure of calcium phosphate cement. J Biomed Mater Res 2002;63:1-9.
23. Zhao F, Lu WW, Luk KDK, Cheung KMC, Wong CT, Leong JCY, Yao KD. Surface treatment of Injectable strontium-containing bioactive bone cement for vertebroplasty. J Biomed Mater Res B: Appl Biomater 2004;69:79-86.
24. Jegou Sint-Jean S, Camirè CL, Nevsten P, Hansen S, Ginebra MP. Study of the reactivity and in vitro bioactivity of Sr-substituted α-TCP cements. J Mater Sci Mater Med 2005;16:993-1001.
25. Woodard JR, Hilldore AJ, Lan SK, Park CJ, Morgan AW, Eurell JAC, Clark SG, Wheeler MB, Jamison RD, Wagoner Johnson AJ. The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity. Biomaterials 2007;28:45-54.
26. Aubin JE, Liu F, Malaval L, Gupta AK. Osteoblast and chondroblast differentiation. Bone 1995;17:77S-83S.
27. Malaval L, Liu F, Roche P, Aubin JE. Kinetics of osteoprogenitor proliferation and osteoblast differentiation in vitro. J Cell Biochem 1999;74:616-627.
28. Atsushi E, Korenori O, Satoshi I, Shigeyuki E, Takayoshi N, Yukichi U. Effects of α-TCP and TetCP on MC3T3-E1 proliferation, differentiation and mineralization. Biomaterials 2003;24:831-836.
29. Franceschi RT, Iyer BS. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 1992;7:235-246.
30. Cowles EA, DeRome D, Pastizzo G, Brailey LL, Gronowicz GA. Mineralization and the expression of matrix proteins during in vivo bone development. Calcif Tissue Int 1998;62:74-82.
31. Fini M, Giardino R, Borsari V, Torricelli P, Rimondini L, Giavaresi G, Nicoli Aldini N. In vitro behaviour of osteoblasts cultured on orthopaedic biomaterials with different surface roughness, uncoated and fluorohydroxyapatite-coated, relative to the in vivo osteointegration rate. Int J Artif Organs 2003;26:520-528.
32. Mayr-Wohlfart U, Fiedler J Gunther KP, Puhl W, Kessler S. Proliferation and differentiation rates of a human osteoblast-like cell line (SaOS-2) in contact with different bone substitute materials. J Biomed Mater Res 2001;57:132-139.
33. He J, Jang J, Safavi KE, Spangberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:239-245.