Selective isolation of in vitro phase II conjugates using a lipophilic anionic exchange solid phase extraction method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 2, 2008, Pages 242-248

  Gagné, Sébastien ^a   Laterreur, Julie ^a,b   Mahrouche, Louiza ^a,c   Sørensen, Dan ^a   Gauthier, Jacques Yves ^a   Truong, Vouy Linh ^a   Chauret, Nathalie ^a   Lévesque, Jean François ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c Civil and Environmental Engineering   (Canada)

Author keywords

Accurate mass; Glucuronide conjugate; NMR; Phase II metabolite; SPE; Sulfate conjugate

Indexed keywords

DRUG PRODUCTS; EXTRACTION; ION EXCHANGE; NEGATIVE IONS; NUCLEAR MAGNETIC RESONANCE; TOXICITY;

GLUCURONIDE CONJUGATES; SOLID PHASE EXTRACTION; SULFATE CONJUGATES; TOXICOLOGICAL EFFECTS;

METABOLITES;

17ALPHA ETHYNYLESTRADIOL 3 GLUCURONIDE; 4' [(2,2 DIFLUORO 1 HYDROXYETHYL)BIPHENYL 4 YL]CYCLOPROPANECARBOXAMIDE; 6 GINGEROL 4' GLUCURONIDE; DRUG METABOLITE; GLUCURONIDE; SULFATE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DRUG ISOLATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 39749122599     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.01.032     Document Type: Article

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