Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism

Trends in Immunology

Volumn 29, Issue 3, 2008, Pages 99-102

  Bynoe, Margaret S ^a   Viret, Christophe ^b  

^a Department of Obstetrics Gynecology   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE; CD39 ANTIGEN; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

CD4+ T LYMPHOCYTE; CELL FUNCTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; SHORT SURVEY;

ANIMALS; EXTRACELLULAR SPACE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; MICE; NUCLEOTIDES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 39749108699     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2007.12.005     Document Type: Short Survey

References (20)

1. Sitkovsky M.V., and Ohta A. The 'danger' sensors that stop the immune response: the A2 adenosine receptors?. Trends Immunol. 26 (2005) 299-304
2. Sitkovsky M.V., et al. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu. Rev. Immunol. 22 (2004) 657-682
3. Naganuma M., et al. Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J. Immunol. 177 (2006) 2765-2769
4. Deaglio S., et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204 (2007) 1257-1265
5. Odashima M., et al. Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology 129 (2005) 26-33
6. Ohta A., and Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414 (2001) 916-920
7. Huang S., et al. Role of A2A extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion. Blood 90 (1997) 1600-1610
8. Kobie J.J., et al. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine. J. Immunol. 177 (2006) 6780-6786
9. Resta R., et al. Ecto-enzyme and signaling functions of lymphocyte CD73. Immunol. Rev. 161 (1998) 95-109
10. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212 (2006) 8-27
11. Kim J.M., and Rudensky A.R. The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol. Rev. 212 (2006) 86-98
12. + Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110 (2007) 1225-1232
13. Gavin M.A., et al. Foxp3-dependent programme of regulatory T cell differentiation. Nature 445 (2007) 771-775
14. + regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide an ATP: a role for P2X7 receptors. J. Immunol. 175 (2005) 3075-3083
15. Robson S.C., et al. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Semin. Thromb. Hemost. 31 (2005) 217-233
16. la Sala A., et al. Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J. Immunol. 166 (2001) 1611-1617
17. + regulatory cells within the central nervous system. J. Immunol. 175 (2005) 3025-3032
18. + suppressor T cells. J. Clin. Invest. 114 (2004) 1218-1221
19. Bopp T., et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204 (2007) 1303-1310
20. Synnestvedt K., et al. Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediatespermeability changes in intestinal epithelia. J. Clin. Invest. 110 (2002) 993-1002