Use of nebivolol for the treatment of endothelial dysfunction in patients with hypertension: The EDEN registry

Journal of Cardiovascular Pharmacology

Volumn 51, Issue 2, 2008, Pages 202-207

  Masoli, Osvaldo ^a   Redruello, Marcela ^a   Baliño, Néstor Pèrez ^a   Grynberg, Laura ^a   Sonia, Traverso ^a   Collaud, Carlos ^a   Vidal, Luis ^a  

^a HOSPITAL GENERAL DE AGUDOS DR COSME ARGERICH   (Argentina)

Author keywords

adrenoceptor blockade; Atherosclerosis; Endothelial dysfunction; Hypertension; Nebivolol

Indexed keywords

METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; NEBIVOLOL;

ADULT; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; CARDIOVASCULAR RISK; COLD PRESSOR TEST; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; FEMALE; HEART INFARCTION; HEART MUSCLE PERFUSION; HEART RATE; HEMODYNAMICS; HUMAN; HYPERTENSION; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; REGISTER; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BENZOPYRANS; ENDOTHELIUM, VASCULAR; ETHANOLAMINES; FEMALE; HEMODYNAMICS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; REGISTRIES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 39749105367     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31815f5aeb     Document Type: Article

References (42)

1. Vane J, Auggard E, Botting R. Regulatory functions of the vascular endothelium. N Engl J Med. 1990;323:27-36.
2. Fuster V, Badimon L, Badimon JJ, et al. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 1992;326:242-250.
3. Ross R. Atherosclerosis - an inflammatory disease. N Engl Med. 1999;340:115-126.
4. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899-1906.
5. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation. 2005;111:363-368.
6. Halcox JPJ, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial function. Circulation. 2002;106:653-658.
7. Bugiardini R, Manfrini O, Pizzi C, et al. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation. 2004;109:2518-2523.
8. Panza JA, Quyyumi AA, Brush JE Jr, et al. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22-27.
9. Taddei S, Virdis A, Mattei P, et al. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension. 1993;21:929-933.
10. Zeiher AM, Schächinger V, Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. Circulation. 1995;92:1094-1100.
11. Johnstone MT, Creager SJ, Scales KM, et al. Impaired endothelium- dependent coronary vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 1993;88:2510-2516.
12. Creager MA, Cooke JP, Mendelsohn ME, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86:228-234.
13. Perticone F, Ceravolo R, Candigliota M, et al. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes. 2001;50:159-165.
14. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001;104:191-196.
15. Gimbrone M, Naget T, Topper JN. Biomechanical activation: an emerging paradigm in endothelial adhesion biology. J Clin Invest. 1997;99:1809-1813.
16. Ignarro L, Buga G, Wood KS, et al. Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Nat Acad Sci USA. 1987;84:9265-9269.
17. Rees DD, Palmer R, Moncada S. The role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Nat Acad Sci USA. 1989;86:3375-3378.
18. Lüscher TF, Vanhoutte PM. The Endothelium: Modulator of Cardiovascular Function. Boca Raton, FL: CRC Press; 1990.
19. Quyyumi AA. Endothelial function in health and disease: new insights into the genesis of cardiovascular disease. Am J Med. 1998;105:32S-39S.
20. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980; 288:373-376.
21. Ludmer P, Selwyn A, Shook T, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051.
22. Revkin JH, Shear CL, Pouleur HG, et al. Biomarkers in the prevention and treatment of atherosclerosis: need, validation, and future. Pharmacol Rev. 2007;59:40-53.
23. Hasdai D, Gibbons RJ, Holmes DR Jr, et al. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation. 1997;96;3390-3395.
24. Masoli O, Balino NP, Sabate D, et al. Effect of endothelial dysfunction on regional perfusion in myocardial territories supplied by normal and diseased vessels in patients with coronary artery disease. J Nucl Cardiol. 2000;7:199-204.
25. Nabel EG, Ganz P, Gordon JB, et al. Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Circulation. 1988;77:43-52.
26. Zeiher AM, Drexler H, Wollschlaeger H, et al. Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol. 1989;14:1181-1190.
27. Pérez Baliño NA, Liprandi AS, Masoli O, et al. Usefulness of radionuclide ventriculography in assessment of coronary artery spasm. Am J Cardiol. 1987;59:552-558.
28. Campisi R, Czernin J, Schoder H, et al. L-Arginine normalizes coronary vasomotion in long-term smokers. Circulation. 1999;99:491-497.
29. Masoli O, Redruello M, Perez Baliño N, et al. Regional myocardial hypoperfusion 99mTc sestamibi SPECT cold pressor test in patients with angiographically normal coronary arteries and abnormal coronary acetylcholine response. J Nucl Cardiol. 2003;10:11.7.
30. Perez Baliño N, Masoli O, Rudruello M, et al. Myocardial perfusion cold pressor test 99mTc MIBI-SPECT detects both microvascular and epicardial abnormal reactivity in patients with endothelial dysfunction and angiographically normal coronary arteries with intracoronary acetylcholine vasoconstriction. J Am Coll Cardiol. 2003;41:443A-1142-37.
31. Suwaidi JA, Hamasaki S, Higano ST, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948-954.
32. Schindler TH, Hornig B, Buser PT, et al. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. Arterioscler Thromb Vasc Biol. 2003;23:495-501.
33. Cockcroft JR, Chowienczyk PJ, Brett SE, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995;274:1067-1071.
34. Tzemos N, Lim PO, Mac Donald TM. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double blind, crossover study. Circulation. 2001;104:511-514.
35. Dessy C, Saliez J, Ghisdal P, et al. Endothelial b3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation β-blocker nebivolol. Circulation. 2005;112:1198-1205.
36. Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289:2560-2572.
37. Cerqueira MD, Weissman NJ, Dilsizian V, et al. American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539-542.
38. Argimon Pallás J, Jiménez Villa J. Métodos de Investigación Clínica y Epidemiológica. Madrid: Harcourt, 2000.
39. Wirch JL, Wolfe LA, Weissgerber TL, et al. Cold pressor test to evaluate cardiac autonomic function. Appl Physiol Nutr Metab. 2006;31:235-243.
40. Targonski PV, Bonetti PO, Pumper GM, et al. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation. 2003;107:2805-2809.
41. Gottdiener JS, Arnold AM, Aurigemma GP, et al. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol. 2000;35:1628-1637.
42. Barton M, Haudenschild CC. Endothelium and atherogenesis: endothelial therapy revisited. J Cardiovasc Pharmacol. 2001;38(Suppl 2):S23-S25.