Understanding tubulin/microtubule-taxane interactions: A quantitative structure-activity relationship study

Molecular Pharmaceutics

Volumn 5, Issue 1, 2008, Pages 151-161

  Hansch, Corwin ^a   Verma, Rajeshwar P ^a  

^a POMONA COLLEGE   (United States)

Author keywords

Hydrophobicity; Microtubule; Molar refractivity; QSAR; Taxanes; Tubulin; Verloop's sterimol parameters

Indexed keywords

ANTINEOPLASTIC AGENT; DOCETAXEL; PACLITAXEL DERIVATIVE; TAXANE DERIVATIVE; TUBULIN;

ARTICLE; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; HYDROPHOBICITY; MATHEMATICAL MODEL; MICROTUBULE; PRIORITY JOURNAL; PROTEIN INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOMIZATION; STATISTICAL ANALYSIS; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; BRIDGED COMPOUNDS; CATTLE; MICROTUBULES; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PACLITAXEL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; TUBULIN; TUBULIN MODULATORS;

EID: 39749102247     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp700119e     Document Type: Article

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