Efficient ways exist to obtain the optimal sample size in clinical trials in rare diseases

Journal of Clinical Epidemiology

Volumn 61, Issue 4, 2008, Pages 324-330

  van der Lee, J H ^a   Wesseling, J ^a,b   Tanck, M W T ^c   Offringa, M ^a,d  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b RED CROSS HOSPITAL   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Child; Epidemiologic research design; Ethics; Randomized controlled trials; Rare diseases; Sample size

Indexed keywords

CLINICAL DECISION MAKING; CONFIDENCE INTERVAL; METHODOLOGY; PEDIATRICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RARE DISEASE; RESEARCH SUBJECT; REVIEW; SAMPLE SIZE; SIMULATION;

CHILD; EPIDEMIOLOGIC RESEARCH DESIGN; ETHICS, CLINICAL; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RARE DISEASES; SAMPLE SIZE;

EID: 39649124215     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2007.07.008     Document Type: Review

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