Study of carbonyl iron/poly(butylcyanoacrylate) (core/shell) particles as anticancer drug delivery systems. Loading and release properties

European Journal of Pharmaceutical Sciences

Volumn 33, Issue 3, 2008, Pages 252-261

  Arias, José L ^a   Linares Molinero, Fernando ^a   Gallardo, Visitación ^a   Delgado, Ángel V ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Cancer treatment; Controlled release; Drug delivery; Magnetic drug vehicles; Poly(alkylcyanoacrylates)

Indexed keywords

CARBONYL IRON; CYANOACRYLATE DERIVATIVE; FLUOROURACIL; POLY(BUTYL 2 CYANOACRYLATE); TEGAFUR; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; COMPOSITE MATERIAL; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTROPHORESIS; PH MEASUREMENT; POLYMERIZATION; PRIORITY JOURNAL; SPECTROPHOTOMETRY; TRANSMISSION ELECTRON MICROSCOPY;

ANTIMETABOLITES, ANTINEOPLASTIC; DRUG DELIVERY SYSTEMS; ENBUCRILATE; FLUOROURACIL; HYDROGEN-ION CONCENTRATION; IRON COMPOUNDS; NANOPARTICLES; TEGAFUR;

EID: 39649123269     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.12.005     Document Type: Article

References (48)

1. Alexiou Ch., Schmidt A., Klein R., Hulin P., Bergemann Ch., and Arnold W. Magnetic drug targeting: biodistribution and dependency on magnetic field strength. J. Magn. Magn. Mater. 252 (2002) 363-366
2. Arias J.L., Gallardo V., Gómez-Lopera S.A., Plaza R.C., and Delgado A.V. Synthesis and characterization of poly(ethyl-2-cyanoacrylate) nanoparticles with a magnetic core. J. Control. Release 77 (2001) 309-321
3. Arias J.L., Gallardo V., Gómez-Lopera S.A., and Delgado A.V. Loading of 5-fluorouracil to poly(ethyl-2-cyanoacrylate) nanoparticles with a magnetic core. J. Biomed. Nanotech. 1 2 (2005) 214-223
4. Arias J.L., Gallardo V., Linares-Molinero F., and Delgado A.V. Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles. J. Colloid Interface Sci. 299 (2006) 599-607
5. Arias J.L., Gallardo V., Ruiz M.A., and Delgado A.V. Ftorafur loading and controlled release from poly(ethyl-2-cyanoacrylate) and poly(butylcyanoacrylate) nanospheres. Int. J. Pharm. 337 1-2 (2007) 282-290
6. Brasseur N., Brault D., and Couvreur P. Adsorption of hematoporphyrin onto polyalkylcyanoacrylate nanoparticles: carrier capacity and drug release. Int. J. Pharm. 70 (1991) 126-135
7. ® nanospheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model. J. Control. Release 100 (2004) 29-40
8. x rectal cancer after chemoradiation: 5-fluorouracil versus tegafur. Int. J. Radiat. Oncol. Biol. Phys. 51 5 (2001) 1264-1270
9. Chua-Anusorn W., Macey D.J., Webb J., de la Motte Hall P., and Pierre T.G.St. Effects of prolonged iron loading in the rat using both parenteral and dietary routes. Biometals 12 (1999) 103-113
10. Devathali S.D., Gordeuk V.R., Brittenham G.M., Bravo J.R., Hughes M.A., and Keating L.J. Bioavailability of carbonyl iron: a randomized, double-bind study. Eur. J. Haematol. 46 (1991) 272-278
11. Dobson J. Magnetic nanoparticles for drug delivery. Drug Develop. Res. 67 (2006) 55-60
12. Fawaz F., Guyot M., Lagueny A.M., and Devissaguet J.Ph. Ciprofloxacin-loaded polyisobutylcyanoacrylate nanoparticles: preparation and characterization. Int. J. Pharm. 154 (1997) 191-203
13. Gibaud S., Rousseau C., Weingarten C., Favier R., Douay L., Andreux J.P., and Couvreur P. Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSF). J. Control. Release 52 (1998) 131-139
14. González-Martin G., Merino I., Rodríguez-Cabezas M.N., Torres M., Nuñez R., and Osuna A. Characterization and trypanocidal activity of nifurtimox-containing and empty nanoparticles of polyethylcyanoacrylates. J. Pharm. Pharmacol. 50 (1998) 29-35
15. Goodwin S., Peterson C., Hoh C., and Bittner C. Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy. J. Magn. Magn. Mater. 194 (1999) 132-139
16. Greig N.H., Genka S., and Rapoport S.I. Delivery of vital drugs to the brain for the treatment of brain tumors. J. Control. Release 11 (1990) 61-78
17. Gupta A.K., and Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26 (2005) 3995-4021
18. Häfeli U.O. Magnetically modulated therapeutic systems. Int. J. Pharm. 277 1-2 (2004) 19-24
19. Ibrahim A., Couvreur P., Roland M., and Speiser P. New magnetic drug carrier. J. Pharm. Pharmacol. 35 (1983) 59-61
20. Ito A., Shinkai M., Honda H., and Kobayashi T. Medical application of functionalized magnetic nanoparticles. J. Biosci. Bioeng. 1 (2005) 1-11
21. Kattan J., Droz J.P., Couvreur P., Marino J.P., Boutan-Laroze A., Rougier P., Brault P., Vranks H., Grognet J.M., Morge X., and Sancho-Garnier H. Phase I trial and pharmacokinetic evaluation of doxorubicin carried by polyhexylcyanoacrylate nanoparticles. Invest. New Drug 10 (1992) 191-199
22. Lenaerts V., Couvreur P., Christiaens-Leyh D., Joiris E., Roland M., Rollman B., and Speiser P. Degradation of poly(isobutylcyanoacrylate) nanoparticles. Biomaterials 5 (1984) 65-68
23. Leonard F., Kulkarni R., Barndes G., Nelson J., and Cameron J. Synthesis and degradation of poly(alkyl α-cyanoacrylates). J. Appl. Polym. Sci. 10 (1996) 259-272
24. Llovet M.I., Egea M.A., Valero J., Alsina M.A., García M.L., and Chauvet A. Methotrexate-loaded nanoparticles: analysis of drug content and study of the matrix structure. Drug Dev. Ind. Pharm. 21 (1995) 1761-1771
25. Lübbe A.S., Bergemann C., Riess H., Schriever F., Reichardt P., Possinger K., Matthias M., Doerken B., Herrmann F., Guertler R., Hohenberger P., Haas N., Sohr R., Sander B., Lemke A.J., Ohlendorf D., Huhnt W., and Huhn D. Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Res. 56 20 (1996) 4686-4693
26. Lübbe A.S., Bergemann C., Huhnt W., Fricke T., Riess H., Brock J.W., and Huhn D. Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res. 56 20 (1996) 4694-4701
27. Lübbe S., Alexiou Ch., and Bergemann Ch. Clinical applications of magnetic drug targeting. J. Surg. Res. 95 (2001) 200-206
28. Maeda H., Fang J., Inutsuka T., and Kitamoto Y. Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its applications. Int. Immunopharmacol. 3 (2003) 319-328
29. McCarron P.A., Woolfson A.D., and Keating S.M. Sustained release of 5-fluorouracil from polymeric nanoparticles. J. Pharm. Pharmacol. 52 (2000) 1451-1459
30. ® (DT) for patients with advanced hepatocellular carcinoma (HCC). J. Clin. Virol. 36 Suppl. 2 (2006) S179-S1179
31. Müller R.H., Lherm C., Herbort J., and Couvreur P. In vitro model for the degradation of alkylcyanocrylate nanoparticles. Biomaterials 11 (1990) 590-595
32. Müller R.H., Lherm C., Herbort J., and Couvreur P. Propidium-iodide-loaded polyalkylcyanoacrylate particles: labelling conditions and loading capacity. Colloid Polym. Sci. 269 (1991) 147-152
33. Müller R.H., Lherm C., Herbort J., Blunk T., and Couvreur P. Alkylcyanoacrylates drug carriers: I. Physicochemical characterization of nanoparticles with different alkyl chain length. Int. J. Pharm. 84 (1992) 1-11
34. Némati F., Dubernet C., Fessi H., de Verdière A.C., Poupon M.F., Puisieux F., and Couvreur P. Reversion of multidrug resistance using nanoparticles in vitro: influence of the nature of the polymer. Int. J. Pharm. 138 (1996) 237-246
35. Novotný L., Farghali H., Janků I., and Beránek J. The effect of structural modifications of 5-fluorouracil derivatives on their transport and biodegradation by isolated rat jejunum. Cancer Chemother. Pharmacol. 24 (1989) 238-242
36. O'Sullivan C., and Birkinshaw C. Hydrolysis of poly (n-butylcyanoacrylate) nanoparticles using esterase. Polym. Degrad. Stab. 78 (2002) 7-15
37. Okon E., Pouliquen D., Okon P., Kovaleva Z.V., Stepanova T.P., Lavit S.G., Kudryavtsev B.N., and Jallet P. Biodegradation of magnetite dextran nanoparticles in the rat. A histologic and biophysical study. Lab. Invest. 71 6 (1994) 895-903
38. Page M.E., Pinto-Alphandary H., Chachaty E., Andremont A., and Couvreur P. Entrapment of colistin into polyhexylcyanoacrylate nanoparticles: preparation, drug release and tissue distribution in mice. STP Pharm Sci. 6 4 (1996) 298-301
39. Peracchia M.T., Vauthier C., Popa M., Puisieux F., and Couvreur P. Investigation of the formation of sterically stabilized poly(ethyleneglycol/isobutylcyanoacrylate) nanoparticles by chemical grafting of polyethyleneglycol during the polymerization of isobutylcyanoacrylate. STP Pharm Sci. 7 (1997) 513-520
40. Radwan M.A. In vitro evaluation of polyisobutylcyanoacrylate nanoparticles as a controlled drug carrier for theophylline. Drug Dev. Ind. Pharm. 21 20 (1995) 2371-2375
41. Soma C.E., Dubernet C., Bentolila D., Benita S., and Couvreur P. Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles. Biomaterials 21 (2000) 1-7
42. Stein M., and Hamacher E. Degradation of polybutyl 2-cyanoacrylate microparticles. Int. J. Pharm. 80 (1992) R11-R13
43. Sullivan C.O., and Birkinshaw C. In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles. Biomaterials 25 (2004) 4375-4382
44. Tartaj P., Morales M.P., Veintemillas-Verdaguer S., González-Carreño T., and Serna C.J. The preparation of magnetic nanoparticles for applications in biomedicine. J. Phys. D: Appl. Phys. 36 (2003) R182-R197
45. Vauthier C., Dubernet C., Fattal E., Pinto-Alphandary H., and Couvreur P. Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications. Adv. Drug Deliv. Rev. 55 (2003) 519-548
46. Vauthier C., Dubernet C., Chauvierre C., Brigger I., and Couvreur P. Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles. J. Control. Release 93 (2003) 151-160
47. Whittaker P., Ali S.F., Imam S.F., and Dunkel V.C. Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. Regul. Toxicol. Pharm. 36 3 (2002) 280-286
48. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchilin V.P., and Jain R.K. Vascular permeability in a human tumor xenograft: molecular size dependence and cut-off size. Cancer Res. 55 (1995) 3752-3756