A positive correlation between α-glutamate and glutamine on brain 1H-MR spectroscopy and neonatal seizures in moderate and severe hypoxic-ischemic encephalopathy

American Journal of Neuroradiology

Volumn 29, Issue 2, 2008, Pages 216-

  Pu, Yonglin ^a,b   Garg, Ankur ^a   Corby, Rodney ^a   Gao, Jia Hong ^a   Zeng, Chao Mei ^b   Li, Qing Feng ^c  

^a UNIVERSITY OF CHICAGO   (United States)

^b PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^c Wei Hai Jin Hai Wan Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUTAMATE; CREATINE; CREATINE PHOSPHATE; GLUTAMIC ACID; GLUTAMINE; UNCLASSIFIED DRUG;

BASAL GANGLION; BRAIN ISCHEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; HUMAN; LETTER; NERVE CELL LESION; NEWBORN; NEWBORN SEIZURE; PERINATAL ASPHYXIA; PROTON NUCLEAR MAGNETIC RESONANCE; SEIZURE; SYMPTOMATOLOGY; THALAMUS; TISSUE DISTRIBUTION;

BIOLOGICAL MARKERS; BRAIN; EPILEPSY, BENIGN NEONATAL; FEMALE; GLUTAMIC ACID; GLUTAMINE; HUMANS; HYPOXIA, BRAIN; INFANT, NEWBORN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STATISTICS AS TOPIC;

EID: 39649092531     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: 10.3174/ajnr.A0798     Document Type: Letter

References (7)

1. Pu Y, Li QF, Zeng CM, et al. Increased detectability of alpha brain glutamate and glutamine in neonatal hypoxic-ischemic encephalopathy. AJNR Am J Neuroradiol 2000;21:203-12
2. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-45S.
3. Zupanc ML. Neonatal seizures. Pediatr Clin N Am 2004;51:961-78
4. Cramer JA, French J. Quantitative assessment of seizure severity for clinical trials: a review of approaches to seizure components. Epilepsia 2001;42:119-29
5. Barkovich AJ. MR and CT evaluation of profound neonate and infantile asphysia. AJNR Am J Neuroradiol 1992;13:959-72
6. Schneider H, Ballowwitz L, Schachinger H, et al. Anoxic encephalopathy with predominant involvement of basal ganglia, brain stem and spinal cord in prenatal period. Acta Neuropathol 1975;32:287-98
7. Cataltepe O, Towfighi, J, Vannucci RC. Cerebrospinal fluid concentration of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizure. Brain Res 1996;709:326-30