Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures

Brain Research

Volumn 709, Issue 2, 1996, Pages 326-330

  Cataltepe, Oguz ^a,b   Towfighi, Javad ^b   Vannucci, Robert C ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Brain; Hypoxia ischemia; Immaturity; Neurotransmitters; Status epilepticus

Indexed keywords

4 AMINOBUTYRIC ACID; BICUCULLINE; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; CEREBROSPINAL FLUID; CONTROLLED STUDY; DEVELOPMENT; EPILEPSY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030060314     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01437-3     Document Type: Article

References (21)

1. Andiné, P., Sandberg, M., Bågenholm, R., Lehmann, A. and Hagberg, H., Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxia-ischemia, Dev. Brain Res., 64 (1991) 115-120.
2. Cataltepe, O., Barron, T.F., Heitjan, D.F., Vannucci, R.C. and Towfighi, J., Effect of hypoxia-ischemia on bicuculline induced seizures in immature rats: behavioral and electrocortical phenomena, Epilepsia, 36 (1995) 396-403.
3. Cataltepe, O., Vannucci, R.C., Heitjan, D.F. and Towfighi, J., Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat, Pediatr. Res, 38 (1995) 251-257.
4. Fujikawa, D.G., Neuroprotective effect of ketamine administered after status epilepticus onset, Epilepsia, 36 (1995) 186-195.
5. Globus, M.Y-T., Ginsberg, M.D. and Busto, R., Excitotoxic index - a biochemical marker of selective vulnerability, Neurosci. Lett., 127 (1991) 39-42.
6. Gordon, K.E., Simpson, J., Statman, D. and Silverstein, F.S., Effects of perinatal stroke on striatal amino acid efflux in rats studied with in vivo microdialysis, Stroke, 22 (1991) 928-932.
7. Graham, L.T. and Aprison, M.H., Fluorometric determination of aspartate, glutamate, and GABA nerve tissue using enzymatic methods, Anal. Biochem., 15 (1966) 487-497.
8. Jacobson, I. and Hamberger, A., Kainic acid-induced changes in extracellular amino acid levels, evoked potentials and EEG activity in the rabbit olfactory bulb, Brain Res., 348 (1985) 289-296.
9. Lasley, S.N., Roles of neurotransmitter amino acids in seizure severity and experience in the genetically epilepsy-prone rat, Brain Res., 560 (1991) 63-70.
10. Lehmann, A., Hagberg, H., Jacobson, I. and Hamberger, A., Effects of status epilepticus on extracellular amino acids in the hippocampus, Brain Res., 359 (1985) 147-151.
11. Lehmann A., Isacsson, H. and Hamberger, A., Effects of in vivo administration of kainic acid on the extracellular amino acid pool in the rabbit hippocampus, J. Neurochem., 40 (1983) 1314-1320.
12. Lowry, O.H., Passonneau, J.V., Schulz, D.W. and Rock, N.K., The measurement of pyridine nucleotides by enzymatic cycling, J. Biol. Chem., 266 (1961) 2746-2755.
13. Lowry, O.H., Roberts, N.R. and Kapphahn, J.I., The fluorometric measurement of pyridine nucleotides, J. Biol. Chem., 224 (1957) 1047-1064.
14. Lyden, P.D. and Lonzo, L., Combination therapy protects ischemic brain in rats: a glutamate antagonist plus a γ-aminobutyric acid agonist, Stroke, 25 (1994) 188-196.
15. Madden, K.P., Effect of γ-aminobutyric acid modulation on neuronal ischemic in rabbits, Stroke, 25 (1994) 2271-2275.
16. Meldrum, B.S., The role of glutamate in epilepsy and other CNS disorders, Neurology, 44 (1994) S14-S23.
17. Rice, J.E., Vannucci, R.C. and Brierley, J.B., The influence of immaturity on hypoxic-ischemic brain damage in the rat, Ann. Neurol, 9 (1981) 131-141.
18. Silverstein, F.S., Naik, B. and Simpson, J., Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study, Pediatr. Res., 30 (1991) 587-590.
19. Towfighi, J., Yager, J.Y., Housman, C. and Vannucci, R.C., Neuropathology of remote hypoxic-ischemic damage in the imamture rat, Acta Neuropathol, 81 (1991) 578-587.
20. Vannucci, R.C. and Duffy, T.E., Cerebral oxidative and energy metabolism of fetal and neonatal rats during anoxia and during recovery, Am. J. Physiol., 230 (1975) 1269-1275.
21. Young, R.S.K., During, M.J., Aquila, W.J., Tendler, D.T. and Ley, E., Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizures: in vivo microdialysis study in the rabbit, Exp. Neurol., 117 (1992) 204-209.