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Volumn 13, Issue 9, 2007, Pages 1127-1137

Reduced effectiveness of long-term interferon-β treatment on relapses in neutralizing antibody-positive multiple sclerosis patients: A Canadian multiple sclerosis clinic-based study

Author keywords

Binding antibody; Interferon beta; Multiple sclerosis; Neutralizing antibody; Relapse rates

Indexed keywords

BETA INTERFERON; BETA1A INTERFERON; GLATIRAMER; INTERFERON BETA SERINE; NEUTRALIZING ANTIBODY; AUTOANTIBODY; IMMUNOLOGIC FACTOR;

EID: 39549108366     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458507080468     Document Type: Article
Times cited : (35)

References (31)
  • 1
    • 0035954361 scopus 로고    scopus 로고
    • PRISMS. PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS
    • PRISMS. PRISMS-4: long-term efficacy of interferon-beta-1a in relapsing MS. Neurology 2001; 56: 1628-36.
    • (2001) Neurology , vol.56 , pp. 1628-1636
  • 2
    • 0005489101 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 1996; 47: 889-94.
    • (1996) Neurology , vol.47 , pp. 889-894
  • 3
    • 0024724256 scopus 로고
    • Evaluation of neutralizing antibodies in patients treated with recombinant interferon-beta ser
    • Larocca AP, Leung SC, Marcus SG, Colby CB, Borden EC. Evaluation of neutralizing antibodies in patients treated with recombinant interferon-beta ser. J Interferon Res 1989; 9(Suppl 1): S51-S60.
    • (1989) J Interferon Res , vol.9 , Issue.SUPPL. 1
    • Larocca, A.P.1    Leung, S.C.2    Marcus, S.G.3    Colby, C.B.4    Borden, E.C.5
  • 4
    • 0020801811 scopus 로고
    • Immunology of multiple sclerosis
    • Oger J, Roos R, Antel JP. Immunology of multiple sclerosis. Neurol Clin 1983; 1: 655-79.
    • (1983) Neurol Clin , vol.1 , pp. 655-679
    • Oger, J.1    Roos, R.2    Antel, J.P.3
  • 5
    • 0031978274 scopus 로고    scopus 로고
    • Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFN-beta1a
    • Antonelli G, Bagnato F, Pozzilli C, Simeoni E, Bastianelli S, Currenti M et al. Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFN-beta1a. J Interferon Cytokine Res 1998; 18: 345-50.
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 345-350
    • Antonelli, G.1    Bagnato, F.2    Pozzilli, C.3    Simeoni, E.4    Bastianelli, S.5    Currenti, M.6
  • 6
    • 0033763507 scopus 로고    scopus 로고
    • Immunogenicity of interferon-beta in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group
    • Ross C, Clemmesen KM, Svenson M, Sorensen PS, Koch-Henriksen N, Skovgaard GL et al. Immunogenicity of interferon-beta in multiple sclerosis patients: influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group. Ann Neurol 2000; 48: 706-12.
    • (2000) Ann Neurol , vol.48 , pp. 706-712
    • Ross, C.1    Clemmesen, K.M.2    Svenson, M.3    Sorensen, P.S.4    Koch-Henriksen, N.5    Skovgaard, G.L.6
  • 7
    • 0025898683 scopus 로고
    • Antibodies that neutralize human beta interferon biologic activity recognize a linear epitope: Analysis by synthetic peptide mapping
    • Redlich PN, Hoeprich PD, Jr., Colby CB, Grossberg SE. Antibodies that neutralize human beta interferon biologic activity recognize a linear epitope: analysis by synthetic peptide mapping. Proc Natl Acad Sci USA 1991; 88: 4040-4.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4040-4044
    • Redlich, P.N.1    Hoeprich Jr., P.D.2    Colby, C.B.3    Grossberg, S.E.4
  • 8
    • 18244382111 scopus 로고    scopus 로고
    • Mapping of interferon-β epitopes important for receptor binding and activation: Comparison of results achieved using antibody-based methods and alanine substitution mutagenesis
    • Runkel L, deDios C, Karpusas M, Baker D, Li Z, Zafari M et al. Mapping of interferon-β epitopes important for receptor binding and activation: comparison of results achieved using antibody-based methods and alanine substitution mutagenesis. J Interferon Cytokine Res 2001; 21: 931-41.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 931-941
    • Runkel, L.1    deDios, C.2    Karpusas, M.3    Baker, D.4    Li, Z.5    Zafari, M.6
  • 9
    • 0037465461 scopus 로고    scopus 로고
    • Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients
    • Bertolotto A, Gilli F, Sala A, Capobianco M, Malucchi S, Milano E et al. Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients. Neurology 2003; 60: 634-9.
    • (2003) Neurology , vol.60 , pp. 634-639
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3    Capobianco, M.4    Malucchi, S.5    Milano, E.6
  • 10
    • 0032893876 scopus 로고    scopus 로고
    • Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies
    • Deisenhammer F, Reindl M, Harvey J, Gasse T, Dilitz E, Berger T. Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies. Neurology 1999; 52: 1239-43.
    • (1999) Neurology , vol.52 , pp. 1239-1243
    • Deisenhammer, F.1    Reindl, M.2    Harvey, J.3    Gasse, T.4    Dilitz, E.5    Berger, T.6
  • 11
    • 2942592729 scopus 로고    scopus 로고
    • Neutralizing antibodies reduce the efficacy of betaIFN during treatment of multiple sclerosis
    • Malucchi S, Sala A, Gilli F, Bottero R, Di Sapio A, Capobianco M et al. Neutralizing antibodies reduce the efficacy of betaIFN during treatment of multiple sclerosis. Neurology 2004; 62: 2031-7.
    • (2004) Neurology , vol.62 , pp. 2031-2037
    • Malucchi, S.1    Sala, A.2    Gilli, F.3    Bottero, R.4    Di Sapio, A.5    Capobianco, M.6
  • 12
    • 0031841745 scopus 로고    scopus 로고
    • Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRO)
    • Rudick RA, Simonian NA, Alam JA, Campion M, Scaramucci JO, Jones W et al. Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRO). Neurology 1998; 50: 1266-72.
    • (1998) Neurology , vol.50 , pp. 1266-1272
    • Rudick, R.A.1    Simonian, N.A.2    Alam, J.A.3    Campion, M.4    Scaramucci, J.O.5    Jones, W.6
  • 13
    • 10744225329 scopus 로고    scopus 로고
    • Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis
    • Sorensen PS, Ross C, Clemmesen EM, Bendtzen K, Frederiksen JL, Jensen K et al. Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis. Lancet 2003; 362: 1184-91.
    • (2003) Lancet , vol.362 , pp. 1184-1191
    • Sorensen, P.S.1    Ross, C.2    Clemmesen, E.M.3    Bendtzen, K.4    Frederiksen, J.L.5    Jensen, K.6
  • 14
    • 0037172854 scopus 로고    scopus 로고
    • Neutralizing antibodies reduce MxA protein induction in interferon-beta-1a-treated MS patients
    • Vallittu AM, Halminen M, Peltoniemi J, Honen J, Julkunen I, Salmi A et al. Neutralizing antibodies reduce MxA protein induction in interferon-beta-1a-treated MS patients. Neurology 2002; 58: 1786-90.
    • (2002) Neurology , vol.58 , pp. 1786-1790
    • Vallittu, A.M.1    Halminen, M.2    Peltoniemi, J.3    Honen, J.4    Julkunen, I.5    Salmi, A.6
  • 15
    • 0242333124 scopus 로고    scopus 로고
    • MxA gene expression analysis as an interferon-beta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity
    • Pachner A, Narayan K, Price N, Hurd M, Dail D. MxA gene expression analysis as an interferon-beta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity. Mol Diagn 2003; 7: 17-25.
    • (2003) Mol Diagn , vol.7 , pp. 17-25
    • Pachner, A.1    Narayan, K.2    Price, N.3    Hurd, M.4    Dail, D.5
  • 16
    • 0242571616 scopus 로고    scopus 로고
    • The measurement of antibodies binding to IFNbeta in MS patients treated with IFNbeta
    • Pachner AR, Oger J, Palace J. The measurement of antibodies binding to IFNbeta in MS patients treated with IFNbeta. Neurology 2003; 61: S18-20.
    • (2003) Neurology , vol.61
    • Pachner, A.R.1    Oger, J.2    Palace, J.3
  • 17
    • 1642277003 scopus 로고    scopus 로고
    • The clinical impact of interferon beta antibodies in relapsing-remitting MS
    • Perini P, Calabrese M, Biasi G, Gallo P. The clinical impact of interferon beta antibodies in relapsing-remitting MS. J Neurol 2004; 251: 305-9.
    • (2004) J Neurol , vol.251 , pp. 305-309
    • Perini, P.1    Calabrese, M.2    Biasi, G.3    Gallo, P.4
  • 18
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 1995; 45: 1277-85.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 19
    • 22044436956 scopus 로고    scopus 로고
    • Interferon beta-1a in MS: Results following development of neutralizing antibodies in PRISMS
    • Francis GS, Rice GP, Alsop JC. Interferon beta-1a in MS: results following development of neutralizing antibodies in PRISMS. Neurology 2005; 65: 48-55.
    • (2005) Neurology , vol.65 , pp. 48-55
    • Francis, G.S.1    Rice, G.P.2    Alsop, J.C.3
  • 20
    • 0032893144 scopus 로고    scopus 로고
    • The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b
    • Rice GP, Paszner B, Oger J, Lesaux J, Paty D, Ebers G. The evolution of neutralizing antibodies in multiple sclerosis patients treated with interferon beta-1b. Neurology 1999; 52: 1277-9.
    • (1999) Neurology , vol.52 , pp. 1277-1279
    • Rice, G.P.1    Paszner, B.2    Oger, J.3    Lesaux, J.4    Paty, D.5    Ebers, G.6
  • 21
    • 0042932742 scopus 로고    scopus 로고
    • Interrupted therapy: Stopping and switching of the beta-interferons prescribed for MS
    • Tremlett HL, Oger J. Interrupted therapy: stopping and switching of the beta-interferons prescribed for MS. Neurology 2003; 61: 551-4.
    • (2003) Neurology , vol.61 , pp. 551-554
    • Tremlett, H.L.1    Oger, J.2
  • 22
    • 0000669345 scopus 로고
    • Biological and immunological assays of human interferons
    • third edition. Washington, DC: ASM Publishing
    • Grossberg SE, Taylor JL, Siebenlist RE, Jameson P. Biological and immunological assays of human interferons. In Manual of Clinical Immunology, third edition. Washington, DC: ASM Publishing, 1986, pp 295-9.
    • (1986) Manual of Clinical Immunology , pp. 295-299
    • Grossberg, S.E.1    Taylor, J.L.2    Siebenlist, R.E.3    Jameson, P.4
  • 23
    • 0034798067 scopus 로고    scopus 로고
    • The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems
    • Grossberg SE, Kawade Y, Kohase M, Yokoyama H, Finter N. The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems. J Interferon Cytokine Res 2001; 21: 729-42.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 729-742
    • Grossberg, S.E.1    Kawade, Y.2    Kohase, M.3    Yokoyama, H.4    Finter, N.5
  • 24
    • 0034796419 scopus 로고    scopus 로고
    • The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: The tenfold reduction unit
    • Grossberg SE, Kawade V, Kohase M, Klein JP. The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit. J Interferon Cytokine Res 2001; 21: 743-55.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 743-755
    • Grossberg, S.E.1    Kawade, V.2    Kohase, M.3    Klein, J.P.4
  • 26
    • 42149188443 scopus 로고    scopus 로고
    • Suggested limits for high and low neutralizing antibody levels in interferon-beta treated multiple sclerosis patients
    • Gibbs E, Oger J. Suggested limits for high and low neutralizing antibody levels in interferon-beta treated multiple sclerosis patients. Mult Scler 2006; 12: S204.
    • (2006) Mult Scler , vol.12
    • Gibbs, E.1    Oger, J.2
  • 27
    • 0037435532 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b
    • Polman C, Kappos L, White R, DahIke F, Beckmann K, Pozzilli C et al. Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b. Neurology 2003; 60: 37-43.
    • (2003) Neurology , vol.60 , pp. 37-43
    • Polman, C.1    Kappos, L.2    White, R.3    DahIke, F.4    Beckmann, K.5    Pozzilli, C.6
  • 28
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS Study Group
    • PRISMS Study Group. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 1998; 352: 1498-504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 29
    • 20444490479 scopus 로고    scopus 로고
    • Appearance and disappearance of neutralizing antibodies during interferon-beta therapy
    • Sorensen PS, Koch-Henriksen N, Ross C, Clemmesen KM, Bendtzen K. Appearance and disappearance of neutralizing antibodies during interferon-beta therapy. Neurology 2005; 65: 33-9.
    • (2005) Neurology , vol.65 , pp. 33-39
    • Sorensen, P.S.1    Koch-Henriksen, N.2    Ross, C.3    Clemmesen, K.M.4    Bendtzen, K.5
  • 30
    • 0002424035 scopus 로고    scopus 로고
    • In Betaseron®-treated MS patients, in vitro immune function can be a predictor of neutralizing antibody development
    • Abstract
    • Oger J, Vorobeychick G, Paty DW. In Betaseron®-treated MS patients, in vitro immune function can be a predictor of neutralizing antibody development. Neurology 1997; 48: A80 (Abstract).
    • (1997) Neurology , vol.48
    • Oger, J.1    Vorobeychick, G.2    Paty, D.W.3
  • 31
    • 3042526220 scopus 로고    scopus 로고
    • Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis
    • Petkau AJ, White RA, Ebers GC, Reder AT, Sibley WA, Lublin FD et al. Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis. Mult Scler 2004; 10: 126-38.
    • (2004) Mult Scler , vol.10 , pp. 126-138
    • Petkau, A.J.1    White, R.A.2    Ebers, G.C.3    Reder, A.T.4    Sibley, W.A.5    Lublin, F.D.6


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