Mapping of IFN-β epitopes important for receptor binding and biologic activation: Comparison of results achieved using antibody-based methods and alanine substitution mutagenesis

Journal of Interferon and Cytokine Research

Volumn 21, Issue 11, 2001, Pages 931-941

  Runkel, Laura ^a   DeDios, Carole ^a   Karpusas, Michael ^a   Baker, Darren ^a   Li, Zhifang ^a   Zafari, Mohammad ^a   Betzenhauser, Matthew ^a   Muldowney, Celine ^a   Miller, Stephan ^a   Redlich, Philip N ^b   Grossberg, Sidney E ^b   Whitty, Adrian ^a   Hochman, Paula S ^a  

^a BIOGEN   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BETA INTERFERON; EPITOPE; INTERFERON RECEPTOR; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

AMINO ACID SUBSTITUTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING SITE; COMPARATIVE STUDY; COMPLEX FORMATION; EPITOPE MAPPING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STEREOSPECIFICITY;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPE MAPPING; EPITOPES; HUMANS; INTERFERON-BETA; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; SEQUENCE ALIGNMENT;

EID: 18244382111     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999001753289541     Document Type: Article

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