Winner of the 2007 Society for Thermal Medicine Young Investigator Award: Fever-range whole body hyperthermia prevents the onset of type 1 diabetes in non-obese diabetic mice

International Journal of Hyperthermia

Volumn 24, Issue 2, 2008, Pages 141-149

  Capitano, Maegan L ^a   Ertel, Bradley R ^a   Repasky, Elizabeth A ^a   Ostberg, Julie R ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Cytolytic T cells; Fever range whole body hyperthermia; NK cells; NOD mice; Type 1 diabetes

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; CELL PROTECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERTHERMIC THERAPY; IMMUNOREGULATION; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTIC INFILTRATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; REGULATORY MECHANISM; THERMOREGULATION; TREATMENT RESPONSE;

ANIMALS; AWARDS AND PRIZES; BLOOD GLUCOSE; CELL DEATH; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FEMALE; FEVER; HYPERTHERMIA, INDUCED; ISLETS OF LANGERHANS; KILLER CELLS, NATURAL; MICE; MICE, INBRED NOD; T-LYMPHOCYTES, CYTOTOXIC;

EID: 39549093999     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730701858289     Document Type: Article

References (26)

1. Yoon, J-W and Jun, H-S (2005) Autoimmune destruction of pancreatic beta cells. Am J Therapeutics, 12, pp. 580-591.
2. Aly, T., Devendra, D. and Eisenbarth, GS (2005) Immunotherapeutic approaches to prevent, ameliorate, and cure type I diabetes. Am J Therapeutics, 12, pp. 481-490.
3. Makino, S., Kunimoto, K., Muraoka, Y., Mizushima, Y., Katagiri, K. and Kikutani, H. (1980) Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu, 29, pp. 1-13.
4. Kikutani, H. and Makino, S. (1992) The murine autoimmune diabetes model: NOD and related strains. Adv Immunol, 51, pp. 285-322.
5. Anderson, MS and Bluestone, JA (2005) The NOD mouse: A model of immune dysregulation. AnnRev Immunol, 23, pp. 447-485.
6. Sadelain, MWJ, Qin, H-Y, Lauzon, J. and Singh, B. (1990) Prevention of Type I diabetes in NOD mice by adjuvant immunotherapy. Diabetes, 39, pp. 1-6.
7. Ulaeto, D., Lacy, PE, Kipnis, DM, Kanagawa, O. and Unanue, ER (1992) A T cell dormant state in the autoimmune process of nonobese diabetic mic treated with complete Freund's adjuvant. PNAS, 89, pp. 3927-3931.
8. Qin, H-Y, Sadelain, MWJ, Hitchon, C., Lauzon, J. and Singh, B. (1993) Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J Immunol, 150, pp. 2072-2080.
9. Lee, I-F, Qin, H., Trudeau, J., Dutz, J. and Tan, R. (2004) Regulation of autoimmune diabetes by complete Freund's adjuvant is mediated by NK cells. J Immunol, 172, pp. 937-942.
10. Ogasawara, K., Hamerman, JA, Hsin, H., Chikuma, S., Bour-Jordan, H., Chen, T., Pertel, T., Bluestone, JA, Carnaud, C. and Lanier, LL (2003) Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity, 18, pp. 41-51.
11. Ostberg, JR, Gellin, C., Patel, R. and Repasky, EA (2001) Regulatory potential of fever-range whole body hyperthermia on Langerhans cells and lymphocytes in an antigen-dependent cellular immune response. J Immunol, 167, pp. 2666-2670.
12. Ostberg, JR and Repasky, EA (2006) Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function. Cancer. Immunol Immunother, 55, pp. 292-298.
13. Ostberg, JR, Patel, R. and Repasky, EA (2000) Regulation of immune activity by mild (fever-range) whole body hyperthermia: Effects on epidermal Langerhans cells. Cell Stress Chaperones, 5, pp. 458-461.
14. Ostberg, JR, Kabingu, E. and Repasky, EA (2003) Thermal regulation of dendritic cell activation and migration from skin explants. Int J Hyperthermia, 19, pp. 520-533.
15. Pritchard, MT, Li, A. and Repasky, E. (2005) Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages. J Leukocyte Biol, 78, pp. 630-638.
16. Ostberg, JR, Dayanc, BE, Yuan, M., Oflazoglu, E. and Repasky, EA (2007) Enhancement of natural killer (NK) cell cytotoxicity by fever-range thermal stress is dependent upon NKG2D function and is associated with plasma membrane NKG2D clustering and increased expression of MICA on target cells. J Leukocyte Biol, 82, pp. 1322-1331.
17. Burd, R., Dziedzic, TS, Xu, Y., Caligiuri, MA, Subjeck, JR and Repasky, EA (1998) Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever-like) whole body hyperthermia. J Cell Physiol, 177, pp. 137-147.
18. Pritchard, MT, Ostberg, JR, Evans, SS, Burd, R., Kraybill, W., Bull, JM and Repasky, EA (2004) Protocols for simulating the thermal component of fever: Preclinical and clinical experience. Methods, 32, pp. 54-62.
19. Shen, RN, Hornbeck, NB, Shidnia, H., Wu, B., Lu, L. and Broxmeyer, HE (1991) Whole body hyperthermia: A potent radioprotector in vivo. Int J Radiat Oncol, Biol, Phys, 20, pp. 525-530.
20. Thurnher, M., Ramoner, R., Gastl, G., Radmayr, C., Bock, G., Herold, M., Klocker, H. and Bartsch, G. (1997) Bacillus Calmette-Guerin mycobacteria stimulate human blood dendritic cells. Int J Cancer, 70, pp. 128-134.
21. Carnaud, C., Lee, D., Donnars, O., Park, SH, Beavis, A., Koezuka, Y. and Bendelac, A. (1999) Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol, 163, pp. 4647-4650.
22. Zitvogel, L. (2002) Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J Exp Med, 195, pp. F9-F14.
23. Slifka, MK, Pagarigan, RR and Whitton, JL (2000) NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells. J Immunol, 164, pp. 2009-2015.
24. Xu, Y., Choi, J., Hylander, B., Sen, A., Evans, S., Kraybill, W. and Repasky, EA (2007) Fever-range whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin. Int J Hyperthermia, 23, pp. 513-527.
25. Kraybill, W., Olenki, T., Evans, S., Ostberg, J., O'Leary, K., Gibbs, F. and Repasky, EA (2002) A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumors: Correlation with mouse models. Int J Hyperthermia, 18, pp. 253-266.
26. Rowe-Horwege, RW (2006) Hyperthermia, systemic encyclopedia of medical devices and intrumentation. John Wiley and Sons, Inc, New York