Early renal dysfunctions in type 1 diabetes and pathogenesis of diabetic nephropathy

Journal of Nephrology

Volumn 20, Issue SUPPL. 12, 2007, Pages

  Zerbini, Gianpaolo ^a   Gabellini, Daniela ^a   Maestroni, Silvia ^a   Maestroni, Anna ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Diabetic nephropathy; Hyperfiltration; Hypertrophy; Tubular hypothesis; Type 1 diabetes; Vascular hypothesis

Indexed keywords

SODIUM GLUCOSE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN 3;

BLOOD GLUCOSE MONITORING; CARDIOVASCULAR DISEASE; DIABETIC NEPHROPATHY; DISEASE DURATION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY DYSFUNCTION; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY STRUCTURE; MICROALBUMINURIA; NONHUMAN; PATHOGENESIS; REVIEW;

DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; EARLY DIAGNOSIS; FEMALE; HUMANS; KIDNEY; MALE;

EID: 39449135351     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Borch-Johnsen K, Andersen PK, Deckert T. The effect of proteinuria on relative mortality in type I (insulin-dependent) diabetes mellitus. Diabetologia 1985; 28: 590-6.
2. Andersen AR, Christiansen JS, Andersen JK, Kreiner S, Deckert T. Diabetic nephropathy in type I (insulin-dependent) diabetes: an epidemiological study. Diabetologia 1983; 25: 496-501.
3. Seaqvist ER, Goetz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989; 320: 1161-5.
4. Viberti GC, Keen H, Wiseman MJ. Raised arterial pressure in parents of proteinuric insulin dependent diabetics. Br Med J 1987; 295: 515-7.
5. Rudberg S, Stattin EL, Dahlquist G. Familial and perinatal risk factors for micro- and macroalbuminuria in young IDDM patients. Diabetes 1998; 47: 1121-6.
6. Mogensen CE, Keane WF, Bennett PH, Jerums G, Parving HH, Passa P, Steffes MW, Striker GE, Viberti GC. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet 1995; 346: 1080-4.
7. Mogensen CE. Early glomerular hyperfiltration in insulin-dependent diabetics and late nephropathy. Scand J Clin Lab Invest 1986; 46: 201-6.
8. Baumgartl HJ, Sigl G, Banholzer P, Haslbeck M, Standl E. On the prognosis of IDDM patients with large kidneys. Nephrol Dial Transplant 1998; 13: 630-4.
9. Rumpold H, Wolf D, Koeck R, Gunsilius E. Endothelial progenitor cells: a source for therapeutic vasculogenesis? J Cell Mol Med 2004; 8: 509-18.
10. O'Bryan GT, Hostetter TH. The renal hemodynamic basis of diabetic nephropathy. Semin Nephrol 1997; 17: 93-100.
11. Hostetter TH. Hypertrophy and hyperfunction of the diabetic-kidney. J Clin Invest 2001; 107: 161-2.
12. Ditzel J, Brochner-Mortensen J. Tubular reabsorption rates as related to elevated glomerular filtration in diabetic children. Diabetes 1983; 32 (Suppl 2): 28-33.
13. Thomson SC, Deng A, Bao D, Satriano J, Blantz RC, Vallon V. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest 2001; 107: 217-24.
14. Bak M, Thomsen K, Christiansen T, Flyvbjerg A. Renal enlargement precedes renal hyperfiltration in early experimental diabetes in rats. J Am Soc Nephrol 2000; 11: 1287-92.
15. Vallon V, Blantz RC, Thomson SC. Glomerular hyperfiltration and the salt paradox in early type 1 diabetes mellitus: a tubulo-centric view. J Am Soc Nephrol 2003; 14: 530-7.
16. Wolf G, Ziyadeh FN. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 1999; 56: 393-405.
17. Krolewski AS, Canessa M, Warram JH, Laffel LMB, Christlieb AR, Knowler WC, Rand LI. Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus. N Engl J Med 1988; 318: 140-5.
18. Mangili R, Bending JJ, Scott G, Li LK, Gupta A, Viberti GC. Increased sodium-lithium countertransport activity in red cells of patients with insulin-dependent diabetes and nephropathy. N Engl J Med 1988; 318: 146-50.
19. Zerbini G, Bonfanti R, Meschi F, Bognetti E, Paesano PL, Gianolli L, Querques M, Maestroni A, Calori G, Del Maschio A, Fazio F, Luzi L, Chiumello G. Persistent renal hypertrophy and faster decline of GFR precede the development of microalbuminuria in type 1 diabetes. Diabetes 2006; 55: 2620-5.