Enteric delivery of ketoprofen through functionally modified poly(acrylamide-grafted-xanthan)-based pH-sensitive hydrogel beads: Preparation, in vitro and in vivo evaluation

Journal of Drug Targeting

Volumn 16, Issue 2, 2008, Pages 167-177

  Kulkarni, Raghavendra ^a   Sa, Biswanath ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Controlled drug delivery; Copolymer; Ketoprofen; PH sensitive hydrogel; Pharmacodynamic activity; Stomach histopathology

Indexed keywords

COPOLYMER; KETOPROFEN; NITROGEN; POLYACRYLAMIDE XANTHAN; UNCLASSIFIED DRUG; XANTHAN;

ALKALINITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; FEASIBILITY STUDY; GELATION; HISTOPATHOLOGY; HYDROGEL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PAIN; PAW EDEMA; PH; PHARMACODYNAMICS; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH EROSION; STOMACH HEMORRHAGE; STOMACH MUCOSA; STOMACH ULCER; THERMOGRAVIMETRY;

ACRYLIC RESINS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HYDROGELS; HYDROGEN-ION CONCENTRATION; INTESTINES; KETOPROFEN; MALE; POLYMERS; POLYSACCHARIDES, BACTERIAL; RATS; TIME FACTORS;

EID: 39449103580     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860701792399     Document Type: Article

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