Polymethacrylate based microparticulates of insulin for oral delivery, part II: Solid state characterization

Pharmazie

Volumn 63, Issue 2, 2008, Pages 122-128

  Agarwal, Vikas ^a,b   Khan, M A ^a,c   Nazzal, S ^a,d  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b CIMA Labs Inc Minnesota   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EUDRAGIT; INSULIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG STABILITY; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; INSULIN TREATMENT; MICROCAPSULE; MICROENCAPSULATION; SOLID STATE; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYPOGLYCEMIC AGENTS; INSULIN; NANOPARTICLES; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; POWDERS; PROTEIN DENATURATION; SOLID PHASE EXTRACTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 39449100809     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2008.7211     Document Type: Article

References (18)

1. Agarwal V, Khan MA (2001a) Current status of the oral delivery of insulin. Pharm Technol 25(10): 76-90.
2. Agarwal V, Reddy IK, Khan MA (2001b) Polymethacrylate based microparticulates of insulin for oral delivery: Preparation and in vitro dissolution stability in the presence of enzyme inhibitors. Int J Pharm 225: 31-39.
3. Bell LN, Hageman MJ, Muraoka LM (1995) Thermally induced denaturation of lyophilized bovine somatotropin and lysozyme as impacted by moisture and excipients. J Pharm Sci 84: 707-712.
4. Forbes RT, Davis KG, Hindle M, Clarke JG, Maas J (1998) Water vapor sorption studies on the physical stability of a series of spray-dried protein/sugar powders for inhalation. J Pharm Sci 87: 1316-1321.
5. Ford JL, Timmins P (1989) Practical considerations for optimizing and improving the performance and quality of results obtained from thermal analysers. In Ford JL and Hoffmann H (2000) Analytical Methods and Stability Testing of Biopharmaceuticals. In McNally EJ (ed.) Protein Formulation and Delivery, New York: Marcel Dekker, p. 71-110.
6. Kimura T, Sato K, Sugimoto K, Tao R, Murakami T, Kurosaki Y, Nakayama T (1996) Oral administration of insulin as poly(vinyl alcohol)-gel spheres in diabetic rats. Biol Pharm Bull 19: 897-900.
7. Kislalioglu MS, Khan MA, Blount C, Goettsch RW, Bolton S (1991) Physical characterization and dissolution properties of ibuprofen : Eudragit coprecipitates. J Pharm Sci 80: 799-804.
8. Lee JC, Timasheff SN (1981) The stabilization of proteins by sucrose. J Biol Chem 256: 7193-7201.
9. Lee LL, Lee JC (1987) Thermal stability of proteins in the presence of poly(ethylene glycols). Biochemistry 26: 7813-7819.
10. Lee VHL, Kashi SD, Grass GM, Rubas w (2000) Oral route of protein and peptide drug delivery. In: Lee VHL (ed.) Peptide and Protein Drug Delivery, Marcel Dekker, New York, p. 691-740.
11. Manning MC, Patel K, Borchardt RT (1989) Stability of protein pharmaeuticals. Pharm Res 6: 903-918.
12. Morishita I, Morishita M, Takayama K, Machida Y, Nagai T (1992) Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. Int J Pharm 78: 9-16.
13. Pearlman R, Nguyen, TH (1991) Analysis of Protein Drugs. In Lee VHL (ed.) Peptide and Protein Drug Delivery, New York: Marcel Dekker, pp. 247-301.
14. Pikal MJ, Rigsbee DR (1997) Stability of insulin in crystalline and amorphous solids: observation of greater stability for the amorphous form. Pharm Res 14: 1379-1387.
15. Shao PG, Bailey LC (2000) Porcine insulin biodegradable polyester microspheres: stability and in vitro release characteristics. Pharm Dev Technol 5: 1-9.
16. Susi H, Byler DM (1986) Resolution-enhanced Fourier transform infrared spectroscopy of enzymes. Methods Enzymol 130: 290-311.
17. Timmins P (eds.) Pharmaceutical Thermal Analysis Techniques and Applications. West Sussex: Ellis Horwood, p. 69-84.
18. Trenktrog T, Muller BW, Specht FM, Seifert J (1996) Enteric coated insulin pellets: development, drug release and in vivo evaluation. Eur J Pharm Sci 4: 323-329.