In vitro and in vivo analysis of expression cassettes designed for vascular gene transfer

Gene Therapy

Volumn 15, Issue 5, 2008, Pages 340-346

  White, S J ^a   Papadakis, E D ^a   Rogers, C A ^a   Johnson, J L ^a   Biessen, E A L ^b   Newby, A C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANGIOPOIETIN RECEPTOR; CELL ADHESION MOLECULE; NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PLASMID VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENHANCER REGION; EXPRESSION VECTOR; GENE CASSETTE; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; TISSUE SPECIFICITY; TRANSGENICS; VASCULAR GENE TRANFER;

ADENOVIRIDAE; CHI-SQUARE DISTRIBUTION; ENDOTHELIAL CELLS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; INTRONS; LINEAR MODELS; LIVER; LUCIFERASES; MUSCLE, SMOOTH, VASCULAR; PROMOTER REGIONS (GENETICS); RECEPTOR, TIE-2; SCAVENGER RECEPTORS, CLASS E; TRANSDUCTION, GENETIC; VASCULAR DISEASES;

CYTOMEGALOVIRUS;

EID: 39449096941     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3303058     Document Type: Article

References (34)

1. Landmesser U, Hornig B, Drexler H. Endothelial function - a critical determinant in atherosclerosis? Circulation 2004; 109: 27-33.
2. White SJ, Newby AC. Gene therapy for all aspects of vein-graft disease. J Card Surg 2002; 17: 549-555.
3. Brewster LP, Brey EM, Greisler HP. Cardiovascular gene delivery: The good road is awaiting. Adv Drug Deliv Rev 2006; 58: 604-629.
4. Jazwa A, Jozkowicz A, Dulak J. New vectors and strategies for cardiovascular gene therapy. Curr Gene Ther 2007; 7: 7-23.
5. Higuchi Y, Hirayama A, Shimizu M, Sakakibara T, Kodama K. Postoperative changes in angiographically normal saphenous vein coronary bypass grafts using intravascular ultrasound. Heart Vessels 2002; 17: 57-60.
6. Kimura T, Kaburagi S, Tamura T, Yokoi H, Nakagawa Y, Yokoi H et al Remodeling of human coronary arteries undergoing coronary angioplasty or atherectomy. Circulation 1997; 96: 475-483.
7. De Geest B, Van Linthout S, Lox M, Collen D, Holvoet P. Sustained expression of human apoliprotein A-I after adenoviral gene transfer in C57BL/6 mice: Role of apolipoprotein A-I promoter, apolipoprotein A-I introns, and human apolipoprotein E enhancer. Hum Gene Ther 2000; 11: 101-112.
8. Morishita K, Johnson DE, Williams LT. A novel promoter for vascular endothelial growth factor receptor. (flt-1) that confers endothelial-specific gene expression. J Biol Chem 1995; 270: 27948-27953.
9. Cowan PJ, Shinkel TA, Witwort EJ, Barlow H, Pearte MJ, D'Apice AJF. Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter. Transplantation 1996, 62: 155-160.
10. Hegen A, Kordl S, Weindel K, Marme D, Augustin HG, Fiedler U Expression of angiopoiefin-2 in endothenal cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol 2004; 24: 1803-1809.
11. Karantzoulis-Fegaras F, Antoniou H, Lai SLM, Kulkarni G, D'Abreo C, Wong GKT et al. Characterization of the human endothelial nitric-oxide synthase promoter. J Biol Chem 1999; 274. 3076-3093.
12. Neish AS, Williams AJ, Palmer, HJ, Whiley MZ, Collins T. Functional analysis of the human vascular adhesion molecule 1 promoter. J Exp Med 1992; 176: 1583-1593.
13. Jahroudi N, Lynch DC. Endothelial-cell-specific regulation of von Willebrand factor gene expression. Mol Cell Biol 1994; 14: 999-1008.
14. Korhonen J, Lahtinen I, Halmekyto M, Alhonen L, Janne J, Dumont D et al. Endothelial-specific gene expression directed by the tie gene promoter in vivo. Blood, 1995; 86: 1828-1835.
15. Patterson C, Perrella MA, Hsieh C-M, Yoshizumi M, Lee M-E, Haber E. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem 1995; 270: 23111-23118.
16. Minami T, Kuivenhoven JA, Evans V, Kodama T, Rosenberg RD, Aird WC. Ets motifs necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol 2003; 23: 2041-2047.
17. Aoyama T, Sawamura T, Furutani Y, Matsuoka R, Yoshida MC, Fujiwara H et al. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem J 1999; 339: 177-184.
18. Yamanaka S, Zhang XY, Miura K, Kim S, Iwao H. The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile. Genomics, 1998; 54: 191-199.
19. Hou JZ, Baichwal V, Cao ZD. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular-adhesion molcule-1. Proc Natl Acad Sci USA 1994; 91: 11641-11645.
20. Tessitore A, Pastore L, Rispoli A, Cilenti L, Toniato E, Flati V et al. Two gamma-interferon-activation sites (GAS) on the promoter of the human intercellular adhesion molecule (ICAM-1) gene are required for induction of transcription by IFN-gamma. Eur J Biochem 1998; 258: 968-975.
21. Laumonnier Y, Nadaud S, Agrapart M, Soubrier F. Characterization of an upstream enhancer region in the promoter of the human endothelial nitric-oxide synthase gene. J Biol Chem 2000; 275: 40732-40741.
22. Schlaeger TM, Bartunkova S, Lawitts JA, Teichmann G, Risau W, Deutsch U et al. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci USA 1997; 94: 3058-3063.
23. Antoniou M, Geraghty F, Hurst J, Grosveld F. Efficient 3′-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction. Nucl Acids Res 1998; 26: 721-719.
24. Nicklin SA, Reynolds PN, Brosnan MJ, White SJ, Curiel DT, Dominiczak AF et al. Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension 2001; 38: 65-70.
25. Chen J, Liu Y, Liu H, Hermonat PL, Mehta JL. Molecular dissection of angiotensin II-activated human LOX-1 promoter. Arterioscler Thromb Vasc Biol 2006; 26: 1163-1168.
26. Yamamoto M, Davydova J, Takayama K, Alemany R, Curiel DT. Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with E1 deleted. J Virol 2003; 77: 1633-1637.
27. Papadakis ED, Nicklin SA, Baker AH, White SJ. Promoters and control elements: Designing expression cassettes for gene therapy. Curr Gene Ther 2004; 4: 89-113.
28. Pajusola K, Gruchala M, Joch H, Luscher TF, Yla-Herttuala S, Bueler H. Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells. J Virol 2002; 76: 11530-11540.
29. Hegenbarth S, Gerolami R, Protzer U, Tran PL, Brechot C, Cerken G et al. Liver sinusoidal endothelial cells are not permissive for adenovirus type 5. Hum Gene Ther 2000; 11: 481-486.
30. Ehrhardt A, Peng PD, Xu H, Meuse L, Kay MA. Optimization of cis acting elements for gene expression from nonviral vectors in vivo. Hum Gene Ther 2003; 14: 215-225.
31. McGrory WJ, Bautista DS, Graham FL. A. simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 1988; 163: 614-617.
32. -/- mice. FASED J 2001; 15: U19-U37.
33. Wilkinson GWG, Akrigg A. Constitutive and enhanced expression from the CMW major IE promoter in a defective adenovirus vector. Nucleic Acids Res 1992; 20: 2233-2239.
34. Geddes BJ, Harding TC, Lightman SL, Uney JB. Long-term gene therapy in the CNS: Reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nat Med 1997; 3: 1402-1404.