Heparins and mechanical methods for thromboprophylaxis in colorectal surgery

Cochrane Database of Systematic Reviews

Volumn 2010, Issue 1, 2004, Pages

  Wille Jørgensen, Peer ^a   Rasmussen, Morten Schnack ^a   Andersen, Betina Ristorp ^b   Borly, Lars ^c  

^a BISPEBJERG HOSPITAL   (Denmark)

^b HILLERØD HOSPITAL   (Denmark)

^c Naestved University Hospital   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 3943081707     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD001217     Document Type: Article

References (111)

1. Butson AR. Intermittent pneumatic calf compression for prevention of deep venous thrombosis in general abdominal surgery. Am J Surg 1981;142(2):525-7. [MEDLINE: 82021671; 1254]
2. Covey TH, Sherman L, Baue AE. Low-dose heparin in postoperative patients: a prospective, coded study. Arch Surg 1975;110:1021-1026. [525]
3. Fricker JP, Vergnes Y, Schach R, Heitz A, Eber M, Grunebaum L, et al. Low dose heparin versus low molecular weight heparin (Kabi 2165, Fragmin) in the prophylaxis of thromboembolic complications of abdominal oncological surgery. Eur J Clin Invest 1988;18(6):561-567. [MEDLINE: 89137198; 176]
4. Gallus AS, Hirsh J, O'Brien SE, McBride JA, Tuttle RJ, Gent M. Prevention of venous thrombosis with small, subcutaneous doses of heparin. JAMA 1976;235:1980-1982. [526]
5. Ho YH, Seow-Choen F, Leong A, Eu KW, Nyam D, Teoh MK. Randomized, controlled trial of low molecular weight heparin vs. no deep vein thrombosis prophylaxis for major colon and rectal surgery in Asian patients. Dis Colon Rectum 1999;42:196-203. [524]
6. Joffe S. Drug prevention of postoperative deep vein thrombosis. A compararative study of calcium heparinate and sodium pentosan polysulfate. Arch Surg 1976;111:37-40. [527]
7. Koppenhagen K, Adolf J, Matthes M, Troster E, Roder JD, Hass S, et al. Low molecular weight heparin and prevention of postoperative thrombosis in abdominal surgery. Thromb Haemost 1992;67(6):627-30. [MEDLINE: 92376750; 274]
8. Kosir MA, Kozol RA, Perales A, McGee K, Beleski K, Lange P, et al. Is DVT prophylaxis overemphasized? A randomized prospective study. J-Surg-Res 1996;60:289-92. [MEDLINE: CN-00006333 - CCTR. MEDLINE 96173505 EMBASE 96068622; 277]
9. Lahnborg G, Bergstrom K, Friman L, Lagergren H. Effect of low-dose heparin on incidence of postoperative pulmonary embolism detected by photoscanning. Lancet 1974;1:329-331. [528]
10. Maressi A, Balzano G, Mari G, D´Angelo SV, Valle PD, Di Carlo V, et al. Prevention of Postoperative Deep Vein Thrombosis in Cancer Patients. A Randomized Trial with Low Molecular Weight Heparin (CY 216). Int Surg 1993;78:166-70.
11. Mcleod RS, Geerts WH, Sniderman K, Greenwood C, Gregoire RC Taylor BM, Silverman RE, Atkinson KG, Burnstein M, Marshall JC, Burul, CJ, Anderson DR, Ross T, Wilson SR, Barton P and other invetigators of the Canadian Colorectal Surgery DVT Prophylaxis Trial. Subcutaneous Heparin Versus Low-Molecular- Weight Heparin as Thromboprophylaxis in patients undergoung Colorectal Surgery. Results of the Canadian Colorectal DVT Prophylaxis Trial: A Randomized, Double-BlindTrial. Annals of Surgery 2001;233(3):438-444.
12. Negus D, Friedgood A. Ultra-low dose intravenous heparin in the prevention of postoperative deep vein thrombosis. Lancet 1980;1:891-894. [523]
13. Nicolaides AN, Miles C, Hoare M, Jury P, Helmis E, Venniker R. Intermittent sequential pneumatic compression of the legs and thromboembolism-deterrent stockings in the prevention of postoperative deep venous thrombosis. Surgery 1983;94(1):21-5. [MEDLINE: 83224179; 346]
14. Onarheim H, Lund T, Heimdal A, Arnesjo B. A low molecular weight heparin (KABI 2165) for prophylaxis of postoperative deep venous thrombosis. Acta Chir Scand 1986;152:593-596. [MEDLINE: 87123126; 356]
15. Rem J, Duckert F, Fridrich R, Gruber UF. Subcutaneous small heparin doses for the prevention of thrombosis in general surgery and urology [Subcutane kleine heparindosen zur thromboseprophylaxe in der allgemeinen chirurgie und urologie]. Schweiz Med Wochenschr 1975;105(26):827-35. [MEDLINE: 76129481; 384]
16. Torngren S, Forsberg K. Concentrated or diluted heparin prophylaxis of postoperative deep venous thrombosis. Acta-Chir-Scand 1978;144:283-285. [MEDLINE: CN-00202745 - CCTR. MEDLINE 79100149 EMBASE 79071859; 454]
17. Valle I, Sola G, Origone A. Controlled clinical study of the efficacy of a new low molecular weight heparin administered subcutaneously to prevent post-operative deep venous thrombosis. Curr-Med-Res-Opin 1988;11:80-86. [MEDLINE: CN-00068595 - CCTR. MEDLINE 89120181; 468]
18. Wille-Jorgensen P. Lavdosis-heparin kombineret med enten dihyroergotamin eller graderede støttestrømper [Low-dosage heparin combined with either dihydroergotamine or graduated supportive stockings. Combined prevention of thrombosis in colonic surgery]]. Ugeskr Laeger 1986;148:501-503. [MEDLINE: 86181188; 492]
19. Wille-Jorgensen P, Hauch O, Dimo B, Christensen SW, Jensen R, Hansen B. Prophylaxis of deep venous thrombosis after acute abdominal operation. Surg Gynecol Obstet 1991;172:44-48. [493]
20. Bounameaux H, Huber O, Khabiri E, Schneider PA, Didier D, Rohner A. Unexpectedly high rate of phlebographic deep venous thrombosis following elective general abdominal surgery among patients given prophylaxis with low-molecular-weight heparin. Arch Surg. 1993;128:326-8.
21. Browse NL, Jackson BT, Mayo ME, Negus. The value of mechanical methods of preventing postoperative calf vein thrombosis. Br.J.Surg 1974;61(3):219-23. [529]
22. Comerota AJ. Review of the Multicenter Trial Committee report: a prospective, randomized study on the prophylaxis of postoperative deep venous thrombosis. Pharmacotherapy. 1986;6:18S-22S.
23. Ellis H, Scurr JH. Prophylaxis of venous thrombosis. Phlebologie 1982;35:135-42.
24. Gallus A, Cade J, Ockelford P, Hepburn S, Maas M, Magnani H, Bucknall T, Stevens J, Porteous F. Orgaran (Org 10172) or heparin for preventing venous thrombosis after elective surgery for malignant disease? A double-blind, randomised, multicentre comparison. ANZ-Organon Investigators' Group. Thromb Haemost. 1993;70:562-7.
25. Kakkar VV. Multicentre randomized double-blind trial of low molecular weight heparin and standard heparin for prevention of postoperative venous thromboembolism in major abdominal surgery. British Journal Of Surgery 1993;80:S112. [MEDLINE: CN-00128856; 253]
26. Mcleod RS, Geerts WH, Sniderman K, Greenwood C, Gregoire R, Taylor B, et al. Thromboprophylaxis in colorectal surgery - A randomized trial comparing low dose heparin and enoxaparin. Thrombosis and Haemostasis 1995;73(6):973, no 309. [517]
27. No authors listed. Prophylactic efficacy of low-dose dihydroergotamine and heparin in postoperative deep venous thrombosis following intra-abdominal operations. J Vasc Surg 1984;1:608-16. [MEDLINE: 85058460; PubMed 6389909]
28. Rasmussen A, Hansen PT, Lindholt J, Poulsen, T, Toftdahl DB, Gram J, Toftgaard C, Jespersen J. Venous thrombosis after abdominal surgery. A comparison between subcutaneous heparin and antithrombotic stockings, or both. J-Med 1988;19(3 and 4):193-201. [MEDLINE: CN-00068984 - CCTR. MEDLINE 89035909; 1079]
29. Strand L, Bank-Mikkelsen OK, Lindewald H. Small heparin doses as prophylaxis against deep-vein thrombosis in major surgery. Acta-Chir-Scand 1975;141:624-627. [MEDLINE: CN-00195984 - CCTR. MEDLINE 76108173; 441]
30. Torngren S, Rieger A. Prophylaxis of deep venous thrombosis in colorectal surgery. Dis Colon Rectum 1982;25(6):563-6. [458]
31. Torngren S. Low dose heparin and compression stockings in the prevention of postoperative deep venous thrombosis. Br J Surg 1980;67(7):482-4. [MEDLINE: 81022208; 453]
32. Adolf J, Knee H, Roder JD, van de Flierdt E, Siewert JR. Thromboembolism prophylaxis with low molecular weight heparin in abdominal surgery. Dtsch Med Wochenschr 1989;114:48-53.
33. Bergqvist D, Efsing HO, Hallbook T, Lindblad B. Prevention of postoperative thromboembolic complications. A prospective comparison between dextran 70, dihydroergotamin, heparin and a sulphated polysaccharid. 146. Acta Chir Scand 1980;556:559-68.
34. Bergqvist D, Burmark US, Frisell J, Guilbaud O, Hallbook T, Horn A, et al. Thromboprophylactic effect of low molecular weight heparin started in the evening before elective general abdominal surgery: a comparison with low-dose heparin. Semin Thromb Hemost 1990;16 Suppl:19-24.
35. Bergqvist D. Low molecular weight heparin once daily compared with conventional low-dose heparin twice daily. A prosepctive double-blind multicentre trial on prevention of postoperative thrombosis. Br.J.Surg. 1986;73:204-8.
36. Bergqvist D, Burmark US, Frisell J, Hallbook T, Lindblad B, Risberg B, et al. Prospective double-blind comparison between Fragmin and conventional low-dose heparin: thromboprophylactic effect and bleeding complications. Haemostasis 1986;16 Suppl:2:11-8.
37. Bergqvist D, Matzsch T, Burmark US, Frisell J, Guilbaud O, Hallbook T, et al. Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis [published erratum appears in Br J Surg 1988 Nov;75(11):1077]. Br J Surg. 1988;75(11):888-91.
38. Bergqvist D, Burmark US, Frisell J, Guilbaud O, Hallbook T, Horn A, et al. Thromboprophylactic effect of low molecular weight heparin started in the evening before elective general abdominal surgery: a comparison with low-dose heparin. Semin Thromb Hemost 1990;16 Suppl.:19-24.
39. Bergqvist D, Lindgren B, Matzsch T. Glycosaminnoglycans in prophylaxis against venous thromboembolism. Adv Exp Med Biol 1992;313:259-74.
40. Bergqvist D, Burmark US, Flordal PA, Frisell J, Hallbook T, Hedberg M, et al. Low molecular weight heparin started before surgery as prophylaxis against deep vein thrombosis: 2500 versus 5000 XaI units in 2070 patients. British Journal of Surgery 1995;82:496-501.
41. Bergqvist D, Flordal PA, Friberg B, Frisell J, Hedberg M, Ljungstrom KG, et al. Thromboprophylaxis with a low molecular weight heparin (tinzaparin) in emergency abdominal surgery. A double-blind multicenter trial. Vasa 1996;25:156-60.
42. Boneu B. An international multicentre study: Clivarin in the prevention of venous thromboembolism in patients undergoing general surgery. Report of the International Clivarin Assessment Group.. Blood Coagul Fibrinolysis 1993;4 Suppl 1:S21-2.
43. Borow M, Goldson HJ. Prevention of Postoperative Deep Venous Thrombosis and Pulmonary Emboli with Combined Modalities. Am Surg 1983;49:599-605.
44. Breddin K, Haring R, Koppenhagen K. Prevention of postoperative thrombotic complications with heparin and dihydroergotamine. A randomized double-blind study. Dtsch Med Wochenschr. 1983;108:98-102.
45. Buttermann G, Theisinger W, Weidenbach A, Hartung R, Welzel D, Pabst HW. [Quantitative assessment of drug-induced prophylaxis of postoperative thromboembolism. Comparison of frequencies of deep vein thrombosis and pulmonary embolism using acetylsalicylic-acid, dextran, dihydroergotamine, low-dose heparin and the fixed combination of heparin and dihydroergotamine (author's transl)]. Med Klin. 1977;72:1624-38.
46. Cade JF, Wood M, Magnani HN, Westlake GW. Early clinical experience of a new heparinoid, Org 10172, in prevention of deep venous thrombosis. Thromb Res 1987;45:497-503.
47. Caen JP. A randomized double-blind study between a low molecular weight heparin Kabi 2165 and standard heparin in the prevention of deep vein thrombosis in general surgery. A French multicenter trial. Thromb Haemost. 1988;59:216-20.
48. Comerota AJ, White JV. The use of dihydroergotamine and heparin in the prophylaxis of deep venous thrombosis. Chest 1986;89:389S-95S.
49. Creperio G, Marabini M, Ciocia G, Bergonzi M, Fincato M. [Evaluation of the effectiveness and safety of Fragmin (Kabi 2165) versus calcium heparin in the prevention of deep venous thrombosis in general surgery]. Minerva Chir 1990;45:1101-6.
50. The European Fraxiparin Study (EFS) Group. Comparison of a low molecular weight heparin and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery. The European Fraxiparin Study (EFS) Group. Br J Surg. 1988;75:1058-63.
51. Encke A. Comparison of a low molecular weight heparin and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery. Br J Surg 1988;75:1058-63.
52. Enoxacan Study Group. Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep vein thrombosis in elective cancer surgery: a double-blind randomized multicentre trial with venographic assessment. ENOXACAN Study Group. Br J Surg 1997;84:1099-103.
53. Garcea D, Martuzzi F, Santelmo N, Savoia M, Casertano MG, Furno A, et al. Post-surgical deep vein thrombosis prevention: evaluation of the risk/benefit ratio of fractionated and unfractionated heparin. Curr Med Res Opin. 1992;12:572-83.
54. Gazzaniga GM, Angelini G, Pastorino G, Santoro E, Lucchini M, Dal Pra ML. Enoxaparin in the prevention of deep venous thrombosis after major surgery: multicentric study. The Italian Study Group. Int Surg 1993;78:271-5.
55. Gruber UF, Duckert F, Fridrich R, Torhorst J, Rem J. Prevention of postoperative thromboembolism by dextran 40, low doses of heparin, or xantinol nicotinate. Lancet 1977;1:207-10.
56. Hartl P, Brucke P, Dienstl E, Vinazzer H. Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragming. Thromb Res 1990;57:577-84.
57. Heather BP, Greenhalgh RM. Prophylaxis of early post operative deep venous thrombosis by monitored heparin infusion. Phlebologie 1982;35:173-85.
58. Kakkar VV, Corrigan T, Spindler J, Fossard DP, Flute PT, Crellin RQ. Efficacy of low doses of heparin in prevention of deepvein thrombosis after major surgery. Lancet 1972;2:101-5.
59. Kakkar VV, Murray WJ. Efficacy and safety of low-molecular-weight heparin (CY216) in preventing postoperative venous thrombo-embolism: a co-operative study. Br J Surg 1985;72:786-91.
60. Kakkar VV, Kakkar S, Sanderson RM, Peers CE. Efficacy and safety of two regimens of low molecular weight heparin fragment (Fragmin) in preventing postoperative venous thrombolism. Haemostasis 1986;16 Suppl 2:19-24.
61. Kakkar VV, Cohen AT, Edmonson RA, Phillips MJ, Cooper DJ, Das S, et al. Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. The Thromboprophylaxis Collaborative Group [see comments]. Lancet 1993;341:259-65.
62. Kakkar VV, Boeckl O, Boneu B, Bordenave L, Brehm OA, Brucke P, et al. Efficacy and safety of a low-molecular-weight heparin and standard unfractionated heparin for prophylaxis of postoperative venous thromboembolism: European multicenter trial. World J Surg 1997;21:2-8; discussion 8-9.
63. Koller M, Schoch U, Buchmann P, Largiader F, von Felten A, Frick PG. Thrombosis prophylaxis in visceral surgery with the low molecular weight heparin fragment Kabi 2165 (7,500 and 2,500 anti-Xa IU/day). Haemostasis. 1986;16 Suppl 2:69-70.
64. Kosir MA, Schmittinger L, Barno Winarski L, Duddella P, Pone M, Perales A, et al. Prospective double-arm study of fibrinolysis in surgical patients. J Surg Res 1998;74:96-101.
65. Lahnborg G, Bergstrom K. Clinical and haemostatic parameters related to thromboembolism and low-dose heparin prophylaxis in major surgery. Acta Chir Scand 1975;141(7):590-5.
66. Lareng L, Vaysse C, Plante J, Boneu B, Gouzi M. Prevention of postoperative thromboembolic disease in general surgery. A randomized trial of two therapeutic procedures evaluated by the method of I labelled fibrinogen. Anaesth Analg (Paris) 1978;35(6):1185-93.
67. Leypold J, Privara M, Stepankova S. [Prevention of postoperative thromboembolic accidents using small doses of heparin]. Rozhl Chir 1984;63(8-9):611-5.
68. Liezorovicz A, Picolet H, Peyrieux JC, Boissel JP. Prevention of perioperative deep vein thrombosis in general surgery: a multicentre double blind study comparing two doses of Logiparin and standard heparin. H.B.P.M. Research Group. Br J Surg 1991;78:412-16.
69. Limmer J, Ellbruck D, Muller H, et al. Prospective randomized clinical study in general surgery comparing a new low molecular weight heparin with unfractionated heparin in the prevention of thrombosis. Clin Investig. 1994;72:913-9.
70. Marassi A, Balzano G, Mari G, et al. Prevention of postoperative deep vein thrombosis in cancer patients. A randomized trial with low molecular weight heparin (CY 216). Int Surg. 1993;78:166-70.
71. McLeod RS. The risk of thromboembolism in patients undergoing colorectal surgery. Drugs 1996;52 Suppl 7:38-41.
72. Moreno Gonzalez E, Fontcuberta J, de la Llama F. Prophylaxis of thromboembolic disease with RO-11 (ROVI), during abdominal surgery. EMRO1 (Grupo Fstudio Multicintrico RO-11). Hepatogastroenterology. 1996;43:744-7.
73. Moser G, Froideveaux A. Prophylaxis of Post-operative deep venous thrombosis using small sub-cutaneous heparin doses, associated or not with compressive stockings: comparative study and results [Prophylaxxie des thromboses veineuses profondes postopératoires par des petites doses d´Heparin souscutanes associées ou non au port de bas compressif: étude comparative et résultats]. Schweiz Rundschau Med 1976;65:1015-20.
74. Mühe E. Intermittent sequential high-pressure compression of the leg. A new method of preventing deep vein thrombosis. Am J Surg 1984;147(6):781-5.
75. Negus D, Friedgood A. Ultra-low dose intravenous heparin in the prevention of postoperative deep vein thrombosis. Phlebologie 1982;35:247-58.
76. Nicolaides AN, Dupont P, Douglas N, Lewis JD, Desai S, Jamieson CW. Small doses of subcutaneous hepatin preventing deep.vein thrombosis in major surgery. Br.J.Surg. 1972;59:911.
77. Nurmohamed MT, Verhaeghe R, Haas S, Iriarte JA, Vogel G, van Rij AM, et al. A comparative trial of a low molecular weight heparin (enoxaparin) versus standard heparin for the prophylaxis of postoperative deep vein thrombosis in general surgery. Am J Surg 1995;169:567-71.
78. Ockelford PA, Patterson J, Johns AS. A double-blind randomized placebo controlled trial of thromboprophylaxis in major elective general surgery using once daily injections of a low molecular weight heparin fragment (Fragmin). Thromb Haemost. 1989;62:1046-9.
79. Pezzuoli G, Neri Serneri GG, Settembrini P, Coggi G, Olivari N, Buzzetti G, et al. Prophylaxis of fatal pulmonary embolism in general surgery using low-molecular weight heparin Cy 216: a multicentre, double-blind, randomized, controlled, clinical trial versus placebo (STEP). STEP-Study Group. Int Surg 1989;74:205-10.
80. Codemo R, Galli G, Roveri S. Pezzuoli G, Neri-Serneri GG, Settembrini PG, Coggi G, OlivariN, Negri G, Codemo R, Galli G, Roveri S. Effectiveness and safety of the low-molecular-weight heparin CY 216 in the prevention of fatal pulmonary embolism and thromboembolic death in general surgery. A multicentre, double-blind, randomized, controlled clinical trial versus placebo (STEP). STEP Study Group. Haemostatis 1990;20 Suppl. 1:193-204.
81. Plante J, Boneu B, Vaysse C, Barret A, Gouzi M, Bierme R. Dipyridamole-aspirin versus low doses of heparin in the prophylaxis of deep venous thrombosis in abdominal surgery. Thromb Res. 14 1979;14:399-403.
82. Roberts VC CL. Prevention of postoperative deep vein thrombosis in patients with malignant disease. British Medical Journal 1974;1:358-60.
83. Rodiger H, Nowak W, Kneist W. [Quality requirements in clinical studies in surgery exemplified by prevention of thromboembolism]. Zentralbl Chir. 1991;116:757-60.
84. Rosenberg IL EMPA. Prophylaxis of postoperative leg vein thrombosis by low dose subcutaneous heparin or perioperative calf muscle stimulation: A controlled clinical trial. BMJ 1975;1:649-51.
85. Samama M, Bernard P, Bonnardot JP, Combe-Tamzali S, Lanson Y, Tissot E. Low molecular weight heparin compared with unfractionated heparin in prevention of postoperative thrombosis. Br J Surg 1988;75:128-31.
86. Samama M, Combe-Tamzali S. Prevention of thromboembolic disease in general surgery with enoxaparin. Br.J.Clin.Pract.suppl 1989;65:9-17.
87. Samama M, Combe S. Prevention of thromboembolic disease in general surgery with enoxaparin (Clexane). Acta Chir Scand Suppl 1990;556:91-5.
88. Samama MM. Prevention of postoperative thromboembolism in general surgery with enoxaparin. Ann Cardiol Angeiol (Paris). 1994;43:31-3.
89. Schmitz Huebner U, Bunte H, Freise G, Reers B, Ruschemeyer C, Scherer R, et al. Clinical efficacy of low molecular weight heparin in postoperative thrombosis prophylaxis. Klin Wochenschr 1984;62:349-53.
90. Torngren S, Kettunen K, Lahtinen J, Koppenhagen K, Brucke P, Hartl P, et al. A randomized study of a semisynthetic heparin analogue and heparin in prophylaxis of deep vein thrombosis. Br J Surg 1984;71:817-20.
91. Verardi S, Casciani CU, Nicora E, et al. A multicentre study on LMW-heparin effectiveness in preventing postsurgical thrombosis. Int Angiol 1988;7:19-24.
92. Meissner J, Karon J, Lewandowski K, Lopaciuk S, et al. Zawilska K, Tokarz A, Misiak A, Psuja P, Wislawski S, Szymczak P, Meissner J, Karon J, Lewandowski K, Lopaciuk S, et al. Nebulized heparin and anabolic steroid in the prevention of postoperative deep vein thrombosis following elective abdominal surgery. Folia Haematol Int Mag Klin Morphol Blutforsch 1990;117:699-707.
93. Amagiri SV, Lees TA. Elastic compression stockings for the prevention of deep vein theombosis (Cochrane Review). Cochrane Database of Systematic Reviews 2000, Issue 3.
94. Andersen M, Wille-Jørgensen P. Late complications of asymptomatic deep venous thrombosis. Eur J Surg 1991, 157:527-530. Andersen M, Wille-Jørgensen P. Late complications of asymptomatic deep venous thrombosis Late complications of asymptomatic deep venous thrombosis. Eur J Surg Eur J Surg 1991;157:527-530. 1991;157 157:527-530.:527-30.
95. Clagett GP, Anderson FA, Heit J, Levine MN, Wheeler HB. Prevention of venous thromboembolism. Chest 1995. Chest 1995;108:312s-33s. [1460]
96. Clagett GP, Reisch JS. Prevention of venous thromboembolism in general surgical patients. Ann Surg 1988;208:227-40. [MEDLINE: 88293064; 1292]
97. Collaborative overview. Collaborative overview of randomised trials of antoplatelet therapy - III: reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. BMJ 1994;308:235-46.
98. Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction of fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. N Engl J Med 1988;318:1162-73. [MEDLINE: CN-00072000 - CCTR. MEDLINE 88202030; 1078]
99. Dauzat M, Laroche JP, Deklunder G, Ayoub, J, Quére I, Lopez FM, Janbon C. Diagnosis of acute lower limb deep venous thrombosis with ultrasound: trends ans controversies. J Clin Ultrasound 1997;25(7):343-58. [MEDLINE: 97426095]
100. Haas SK, Wolf H, Encke A, Fareed J. Prevention of fatal pulmonary embolism by low molecular weight heparin - a double blind comparison of certoparin and unfractionated heparin. Thromb Haemostas August 1999;Supplement:491.
101. Jorgensen LN, Wille-Jorgensen P, Hauch O. Prophylaxis of postoperative throm boembolism with low molecular weight heparins. Br J Surg 1993;80:689-704. [MEDLINE: 93321028; 1337]
102. Kjaergaard J, Esbensen K, Wille Jorgensen P, Jorgensen T, Thorup J, Berning H, Wold S. A multivariate pattern recognition study of risk-factors indicating postoperative thromboembolism despite low-dose heparin in major abdominal surgery. Thromb Haemost 1985;54(2):409-12. [MEDLINE: 86097628; 1365]
103. Leizorovicz A, Haugh MC. Low Molecular weight heparinin prevention of perioperative thrombosis. In: Fowkes FGR, Janzon L, Kleijnen J, leng CG (eds.) Pripheral Vascular Diseases Module on The Cochrane Database of Systematic Reviews, (updated August 1997). Available in The Cochrane Library (database on CDROM). The Cochrane Collaboration; Issue 4. Oxford: Update Software; 1997. Cochrane Database of Systematic Reviews 2000, Issue 3.
104. Leizorovicz A, Haugh MC, Chapuis FR, Samama MM, Boissel JP. Low molecular weight hepaprin in prevention of perioperative thrombosis. Brit Med J 1992;305:913-20. [MEDLINE: 93091577; 302]
105. Mantoni M, Strandberg C, Neergaard K, Sloth C, Jørgensen PS, Thamsen H, Tørholm C, Paaske BP, Rasmussen SW, Christensen SW, Wille-Jørgensen P. Triplex US in the diagnosis of asymptomatic deep venous thrombosis. Acta Radiol 1997;38(2):327-31. [MEDLINE: 97247030]
106. Nurmohamed MT, Rosendaal FR, Buller HR, et al. Low molecular weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 1992;340:152-56. [MEDLINE: 92326472; 1418]
107. Siragusa S, Beltrametti C, Barone M, Piovella F. Clinical course and incidence of post-thrombophlebitic syndrome after profound asymptomatic deep vein thrombosis. Minerva Cardioangiol 1997;45:57-66.
108. Wille-Jørgensen, P. Prophylaxis of postoperative thromboembolism. Danish Medical Bulletin 1991;38:203-28.
109. Wille-Jørgensen P, Kjaergaard J, Jørgensen T, Korsgaard Larsen T. Failure in prophylactic management of thromboembolic disease in colorectal surgery. Dis Colon Rectum 1988;31:384-6. [MEDLINE: 1988211380; 1000]
110. Wille-Jorgensen P, Ott P. Predicting failure of low.dose prophylactic heparin in general surgical patients. Surg Gynecol Obstet 1990;171:126-30. [1012]
111. Wille-Jørgensen P, Jørgensen LN, Hauch O, Borris LC, Lassen MR, Nehen AM, Kjær L, Jensen R. Potential influence of observer variation on thromboprophylactic studies. Hæmostasis 1992;22:211-5. [1482]