In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging

BMC Medical Imaging

Volumn 8, Issue , 2008, Pages

  Brandt, Christian T ^a,c   Simonsen, Helle ^b   Liptrot, Matthew ^b   Søgaard, Lise V ^b   Lundgren, Jens D ^c   Østergaard, Christian ^a,d   Frimodt Møller, Niels ^a   Rowland, Ian J ^b,e  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e University of Wisconsin Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GADOLINIUM PENTETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL MENINGITIS; BLOOD BRAIN BARRIER; BLOOD LEVEL; BLOOD VESSEL PERMEABILITY; BRAIN PERFUSION; BRAIN VENTRICLE DILATATION; BRAIN WATER; CEREBROSPINAL FLUID ANALYSIS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; HISTOPATHOLOGY; IN VIVO STUDY; LEUKOCYTE COUNT; MALE; MOTOR PERFORMANCE; MUSCLE PERFUSION; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SCORING SYSTEM; SEPTICEMIA; STREPTOCOCCUS PNEUMONIAE; ANIMAL; BRAIN VENTRICLE; EVALUATION; IMAGE ENHANCEMENT; METHODOLOGY; PATHOLOGY; WISTAR RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CEREBRAL VENTRICLES; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MALE; MENINGITIS, PNEUMOCOCCAL; RATS; RATS, WISTAR;

EID: 39349084062     PISSN: None     EISSN: 14712342     Source Type: Journal    
DOI: 10.1186/1471-2342-8-1     Document Type: Article

References (36)

1. Leib SL Clements JM Lindberg RL Heimgartner C Loeffler JM Pfister LA Tauber MG Leppert D Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis Brain 2001, 124:1734-1742. 10.1093/brain/ 124.9.1734 11522576
2. Tauber MG Borschberg U Sande MA Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis J Infect Dis 1988, 157:456-464. 3343521
3. Koedel U Scheld WM Pfister HW Pathogenesis and pathophysiology of pneumococcal meningitis Lancet Infect Dis 2002, 2:721-736. 10.1016/ S1473-3099(02)00450-4 12467688
4. Brandt CT Lundgren JD Lund SP Frimodt-Moller N Christensen T Benfield T Espersen F Hougaard DM Ostergaard C Attenuation of the bacterial load in blood by pretreatment with granulocyte-colony-stimulating factor protects rats from fatal outcome and brain damage during Streptococcus pneumoniae meningitis Infect Immun 2004, 72:4647-4653. 470620 15271925 10.1128/IAI.72.8.4647-4653.2004
5. Ostergaard C Yieng-Kow RV Benfield T Frimodt-Moller N Espersen F Lundgren JD Inhibition of leukocyte entry into the brain by the selectin blocker fucoidin decreases interleukin-1 (IL-1) levels but increases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits Infect Immun 2000, 68:3153-3157. 97550 10816457 10.1128/IAI.68.6.3153-3157.2000
6. Pedersen M Brandt CT Knudsen GM Ostergaard C Skinhoj P Frimodt-Moller N Moller K Cerebral blood flow autoregulation in early experimental S. pneumoniae meningitis J Appl Physiol 2007, 102:72-78. 10.1152/ japplphysiol.00697.2006 17008439
7. Orihuela CJ Gao G McGee M Yu J Francis KP Tuomanen E Organ-specific models of Streptococcus pneumoniae disease Scand J Infect Dis 2003, 35:647-652. 10.1080/00365540310015854 14620149
8. Kadurugamuwa JL Modi K Coquoz O Rice B Smith S Contag PR Purchio T Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response Infect Immun 2005, 73:7836-7843. 1307043 16299273 10.1128/ IAI.73.12.7836-7843.2005
9. Dijkhuizen RM Nicolay K Magnetic resonance imaging in experimental models of brain disorders J Cereb Blood Flow Metab 2003, 23:1383-1402. 10.1097/01.WCB.0000100341.78607.EB 14663334
10. Wiesmann M Koedel U Bruckmann H Pfister HW Experimental bacterial meningitis in rats: Demonstration of hydrocephalus and meningeal enhancement by magnetic resonance imaging Neurol Res 2002, 24:307-310. 10.1179/016164102101199792 11958427
11. Narayana PA Wolinsky JS Jensen DJ Magnetic resonance imaging of experimental mumps meningoencephalitis in suckling hamsters Magn Reson Med 1987, 4:597-601. 10.1002/mrm.1910040611 3613960
12. Mathews VP Kuharik MA Edwards MK D'Amour PG Azzarelli B Dreesen RG Dyke award. Gd-DTPA-enhanced MR imaging of experimental bacterial meningitis: evaluation and comparison with CT AJR Am J Roentgenol 1989, 152:131-136. 2783267
13. Brandt CT Lundgren JD Frimodt-Moller N Christensen T Benfield T Espersen F Hougaard DM Ostergaard C Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis J Neuroimmunol 2005, 166:126-131. 10.1016/j.jneuroim.2005.05.014 15982752
14. Kastrup O Wanke I Maschke M Neuroimaging of infections NeuroRx 2005, 2:324-332. 1064994 15897953 10.1602/neurorx.2.2.324
15. Jan W Zimmerman RA Bilaniuk LT Hunter JV Simon EM Haselgrove J Diffusion-weighted imaging in acute bacterial meningitis in infancy Neuroradiology 2003, 45:634-639. 10.1007/s00234-003-1035-8 12908092
16. Tupper DE Wallace RB Utility of the neurological examination in rats Acta Neurobiol Exp (Wars) 1980, 40(6):999-1003. 7234526
17. Garcia JH Wagner S Liu KF Hu XJ Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation Stroke 1995, 26:627-634. 7709410
18. Mactier H Galea P McWilliam R Acute obstructive hydrocephalus complicating bacterial meningitis in childhood BMJ 1998, 316:1887-1889. 1113363 9632412
19. Wang KW Chang WN Chang HW Wang HC Lu CH Clinical relevance of hydrocephalus in bacterial meningitis in adults Surg Neurol 2005, 64:61-65. 10.1016/j.surneu.2004.10.009 15993186
20. Hoppe-Hirsch E Laroussinie F Brunet L Sainte-Rose C Renier D Cinalli G Zerah M Pierre-Kahn A Late outcome of the surgical treatment of hydrocephalus Childs Nerv Syst 1998, 14:97-99. 10.1007/s003810050186 9579862
21. Lindvall P Ahlm C Ericsson M Gothefors L Naredi S Koskinen LO Reducing intracranial pressure may increase survival among patients with bacterial meningitis Clin Infect Dis 2004, 38:384-390. 10.1086/380970 14727209
22. Malipiero U Koedel U Pfister HW Leveen P Burki K Reith W Fontana A TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis Brain 2006, 129:2404-2415. 10.1093/ brain/awl192 16891635
23. Papadopoulos MC Verkman AS Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis J Biol Chem 2005, 280:13906-13912. 10.1074/jbc.M413627200 15695511
24. Pfister HW Koedel U Lorenzl S Tomasz A Antioxidants attenuate microvascular changes in the early phase of experimental pneumococcal meningitis in rats Stroke 1992, 23:1798-1804. 1448831
25. Koedel U Pfister HW Tomasz A Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis Brain Res 1994, 644:25-31. 10.1016/0006-8993(94)90342-5 8032946
26. Tauber MG Brain edema, intracranial pressure and cerebral blood flow in bacterial meningitis Pediatr Infect Dis J 1989, 8:915-917. 2696929
27. Loubinoux I Volk A Borredon J Guirimand S Tiffon B Seylaz J Meric P Spreading of vasogenic edema and cytotoxic edema assessed by quantitative diffusion and T2 magnetic resonance imaging Stroke 1997, 28:419-426. 9040700
28. Massicotte EM Buist R Del Bigio MR Altered diffusion and perfusion in hydrocephalic rat brain: A magnetic resonance imaging analysis J Neurosurg 2000, 92:442-447. 10701531
29. Slater AJ Berkowitz ID Wilson DA Traystman RJ Role of leukocytes in cerebral autoregulation and hyperemia in bacterial meningitis in rabbits Am J Physiol 1997, 273:H380-H386. 9249513
30. Ellis CG Bateman RM Sharpe MD Sibbald WJ Gill R Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis Am J Physiol Heart Circ Physiol 2002, 282:H156-H164. 11748059
31. Goldman D Bateman RM Ellis CG Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: Interpreting capillary oxygen transport data using a mathematical model Am J Physiol Heart Circ Physiol 2004, 287:H2535-H2544. 10.1152/ajpheart.00889.2003 15319199
32. Lam C Tyml K Martin C Sibbald W Microvascular perfusion is impaired in a rat model of normotensive sepsis J Clin Invest 1994, 94:2077-2083. 294647 7962554
33. Tureen J Cerebral blood flow and metabolism in experimental meningitis Pediatr Infect Dis J 1989, 8:917-918. 2626304
34. Paulson OB Hansen EL Kristensen HS Brodersen P Cerebral blood flow, cerebral metabolic rate of oxygen and CSF acid-base parameters in patients with acute pyogenic meningitis and with acute encephalitis Acta Neurol Scand Suppl 1972, 51:407-408. 4514362
35. Ashwal S Stringer W Tomasi L Schneider S Thompson J Perkin R Cerebral blood flow and carbon dioxide reactivity in children with bacterial meningitis J Pediatr 1990, 117:523-530. 10.1016/S0022-3476(05)80683-3 2120412
36. Lukasik VM Gillies RJ Animal anaesthesia for in vivo magnetic resonance NMR Biomed 2003, 16:459-467. 10.1002/nbm.836 14696002