Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia

Psychoneuroendocrinology

Volumn 33, Issue 3, 2008, Pages 340-351

  Bernstein, Hans Gert ^a   Lendeckel, Uwe ^a   Dobrowolny, Henrik ^a   Stauch, Renate ^a   Steiner, Johann ^a   Grecksch, Gisela ^a   Becker, Axel ^a   Jirikowski, Gustav F ^b   Bogerts, Bernhard ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Beacon ubiquitin 5 like; Haloperidol; Human brain; Hypothalamus; Immunohistochemistry; Metabolic syndrome; Rat brain; Rat model of schizophrenia; Schizophrenia

Indexed keywords

HALOPERIDOL; UBIQUITIN; UBIQUITIN 5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BODY MASS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MEYNERT BASAL NUCLEUS; MORPHOMETRICS; NEOCORTEX; NEUROBLASTOMA CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SCHIZOPHRENIA; SUPRACHIASMATIC NUCLEUS; SUPRAOPTIC NUCLEUS; THALAMUS; WEIGHT GAIN; ZONA INCERTA;

ANIMALS; ANIMALS, NEWBORN; ANTIPSYCHOTIC AGENTS; ASTROCYTES; CELL LINE, TUMOR; EYE PROTEINS; FEMALE; HALOPERIDOL; HUMANS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NERVE FIBERS; NERVE TISSUE PROTEINS; NEURONS; OBESITY; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PSYCHIATRIC STATUS RATING SCALES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHIZOPHRENIA; SUPRAOPTIC NUCLEUS; UBIQUITINS;

EID: 39149143681     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2007.12.002     Document Type: Article

References (58)

1. Alfonso J., Frick L.R., Silberman D.M., Palumbo M.L., Genaro A.M., and Frasch A.C. Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments. Biol. Psychiatry 59 (2006) 244-251
2. Badenhop R.F., Moses M.J., Scimone A., Mitchell P.B., Ewen-White K.R., Rosso K., Donald D.J., Adams L.J., and Schofield P.L. A genome screen of 13 bipolar affective pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosome 9, 13 and 19. Mol. Psychiatry 7 (2002) 851-859
3. Bassett A.S. Chromosomal aberrations and schizophrenia. Autosomes. Br. J. Psychiatry 161 (1992) 323-334
4. Becker A., Grecksch G., Bernstein H.-G., Höllt V., and Bogerts B. Social behaviour in rats lesioned with ibotenic acid in the hippocampus: quantitative and qualitative analysis. Psychopharmacology 144 (1999) 333-338
5. Bernstein H.-G., Stanarius A., Baumann B., Henning H., Krell D., Danos P., Falkai P., and Bogerts B. Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83 (1998) 867-875
6. Bernstein H.-G., Baumann B., Danos P., Diekmann S., Bogerts B., Gundelfinger E.D., and Braunewell K.-H. Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. J. Neurocytol. 28 (1999) 655-662
7. Bernstein H.-G., Grecksch G., Becker B., Höllt V., and Bogerts B. Cellular changes in rat brain areas associated with neonatal hippocampal damage. Neuroreport 10 (1999) 2307-2311
8. Bernstein H.-G., Lendeckel U., Bertram I., Bukowska A., Kanakis D., Dobrowolny H., Stauch R., Krell D., Mawrin C., Budinger E., Keilhoff G., and Bogerts B. Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain. Brain Res. Bull. 69 (2006) 546-559
9. Bernstein H.-G., Stricker R., Dobrowolny H., Trübner K., Bogerts B., and Reiser G. Histochemical evidence for wide expression of the metalloendopeptidase nardilysin (NRDc) in human brain neurons. Neuroscience 146 (2007) 1513-1523
10. Bernstein, H.-G., Sahin, J., Smalla, K.-H., Gundelfinger, E.D., Bogerts, B., Kreutz., M.R., 2007b. A reduced number of cortical neurons show increased caldendrin protein expression levels in chronic schizophrenia. Schizophr. Res.
11. Bozaoglu K., Curran J.E., Elliot K.S., Walder K.R., Dyer T.D., Rainwater D.L., Van de Berg J.L., Comuzzie P., Collier G.R., Zimmet P., MacCluer J.W., Jowett J.B., and Blangero J. Association of genetic variation within DBL5 with phenotypes of metabolic syndrome. Hum. Biol. 78 (2006) 147-159
12. Brailoiu G.C., Dun S.L., Yang J., Chang J.K., Castellino S., and Dun N.J. Beacon-like immunoreactivity in the hypothalamus of Spague-Dawley rats. Neurosci. Lett. 317 (2002) 166-168
13. Brailoiu G.C., Dun S.L., Chiu M., Ohsawa M., Chang J.K., Yang J., and Dun N.J. Beacon/ubiquitin-like-5 immunoreactivity in the hypothalamus and pituitary of the mouse. Brain Res. 984 (2003) 215-223
14. Bukowska A., Lendeckel U., Hirte D., Wolke C., Striggow F., Röhnert P., Huth C., Klein H.U., and Goette A. Activation of the calcineurin signaling pathway induces atrial hypertrophy during atrial fibrillation. Cell. Mol. Life Sci. 63 (2006) 333-342
15. Casey D.C. Metabolic issues and cardiovascular disease in patients with psychiatric disorders. Am. J. Med. 118 Suppl. 2 (2005) 15S-22S
16. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
17. Collier G.R., McMillan J.S., Windmill K., Walder K., Tenne-Brown J., de Silva A., Trevaskis J., Jones S., Morton G.J., Lee S., Augert G., Civitarese A., and Zimmet P.Z. Beacon: a novel gene involved in the regulation of energy balance. Diabetes 49 (2000) 1766-1771
18. Danos P., Baumann B., Krämer K., Bernstein H.-G., Stauch R., Krell D., Falkai P., and Bogerts B. Volumes of association thalamic nuclei in schizophrenia: a postmortem study. Schizophr. Res. 60 (2003) 141-155
19. Dean B., Crook J.M., Pavey G., Opeskin K., and Copolov D.L. Muscarinic 1 and 2 receptor mRNA in human caudate-putamen: no change in m1 mRNA in schizophrenia. Mol. Psychiatry 5 (2000) 203-207
20. Diagnostic and Statistical Manual of Mental Disorders (3rd ed. revised, DSM-III-R 1987). American Psychiatric Association (Ed.), American Psychiatric Press, Washington, DC, pp. 1-924.
21. Dorn A., Bernstein H.-G., Hahn H.J., and Kostmann G. Occurrence of somatostatin-like immunoreactivity (SLI) in the dorsal hippocampus of the sand rat (Psammomys obesus). Acta histochem. 65 (1979) 276-278
22. Endo K., Hori T., Abe S., and Asada T. Alterations in GABA (A) receptor expression in neonatal ventral hippocampal lesioned rats: comparison of prepubertal and postpubertal periods. Synapse (2007) 357-366
23. Esposito V., de Girolamo P., Gargiulo G., and Dun N.J. Beacon-like immunoreactivity in the hypothalamus of domestic chick. Anat. Histol. Embryol. 35 (2006) 361-364
24. Forloni G., Fisone G., Guaitani A., Ladinsky H., and Consolo S. Role of the hippocampus in the sex-dependent eating behavior: studies with kainic acid. Physiol. Behav. 38 (1986) 321-326
25. Gejman P.V. Chromosomes 19 and 20 report. Am. J. Med. Genet. 88 (1999) 271
26. Grecksch G., Bernstein H.-G., Becker A., Höllt V., and Bogerts B. Disruption of latent inhibition in rats with postnatal hippocampal lesions. Neuropsychopharmacology 20 (1999) 525-532
27. Green A.I., Lieberman J.A., Hamer R.M., Glick I.D., Gur R.E., Kahn R.S., McEvoy J.P., Perkins D.O., Rothschild A.J., Sharma T., Tohen M.F., Woolson S., and Zipursky P.S. Olanzapine and haloperidol in first episode psychosis: two-year data. Schizophr. Res. 86 (2006) 234-243
28. Hamshere M.L., Bennett P., Williams N., Seguardo R., Cardno A., Norton N., Lambert D., Williams H., Kirov G., Corvin A., Holmans P., Jones I., Jones L., Gill M., O'Donovan M.C., Owen M.J., and Craddock N. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch. Gen. Psychiatry 62 (2005) 1081-1088
29. Hatanaka K., Ikegami K., Takagi H., and Setou M. Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of Ubl5. Biochem. Biophys. Res. Commun. 350 (2006) 610-615
30. Jowett J.B., Elliot K.S., Curran J.E., Hunt N., Walder K.R., Collier G.R., Zimmet P.Z., and Blangero J. Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes. Diabetes 53 (2004) 2467-2472
31. Kalra S.P., Dube M.G., Pu S., Xu S., Horvath T.L., and Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrine Rev. 20 (1999) 68-100
32. Kantham L., Kerr-Bayles L., Godde N., Quick M., Webb R., Sunderland T., Bond J., Walder K., Augert G., and Collier G. Beacon interacts with cdc2/cdc28-like kinases. Biochem. Biophys. Res. Commun. 304 (2003) 125-129
33. Koenig J.L. Schizophrenia: a unique translational opportunity in behavioural neuroendocrinology. Horm. Behav. (Basel) 50 (2006) 602-611
34. Lillrank S.M., Lipska B.K., and Weinberger D.R. Neurodevelopmental animal models of schizophrenia. Clin. Neurosci. 3 (1995) 98-104
35. Lipska B.K. Using animal models to test neurodevelopmental hypothesis of schizophrenia. J. Psychiatry Neurosci. 29 (2004) 282-286
36. Lusting H.R. The neuroendocrinology of obesity. In: Klibanski A. (Ed). Neuroendocrinology, Endocrinology and Metabolism Clinics of North America, vol. 30 (2001), Endocrine Society Press, San Diego 764-785
37. Malidelis Y.L., Panayotacopoulou M.T., van Heerikhuize J.J., Unmehopa U.A., Kontostavlaki D.P., and Swaab D.F. Absence of a difference in the neurosecretory activity of supraoptic nucleus vasopressin neurons of neuroleptic-treated schizophrenic patients. Neuroendocrinology 82 (2005) 63-69
38. Mastorakos G., and Zapani E. The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin-releasing hormone. Nutr. Neurosci. 7 (2004) 271-280
39. Mayhew M.H. A review of recent advances in stereology for quantifying neural structure. J. Neurocytol. 21 (1992) 313-328
40. Murata S., Yoshiara T., Lim C.R., Sugino M., Kogure M., Ohnuki T., Komurasaki T., and Matsubara K. Psychophysiological stress-regulated gene expression in mice. FEBS Lett. 579 (2005) 2137-2142
41. Nettles K.W., Pesold C., and Goldman M.B. Influence of the ventral hippocampal formation on plasma vasopressin, hypothalamic-pituitary-adrenal axis, and behavioral responses to novel acoustic stress. Brain Res. 858 (2000) 181-190
42. Ng Y.K., Brailoiu G.C., Dun S.L., Ling E.A., Yang J., Chang J.K., and Dun N.J. Beacon immunoreactivity in the rat hypothalamus. J. Neurosci. Res. 83 (2006) 1106-1117
43. Pato C.N., Pato M.T., Kirby A., Petryshen T.L., Medeiros H., Carvalho C., Macedo A., Dourado A., Coelho I., Valente J., Soares M.J., Ferreira C.P., Lei M., Verner A., Hudson T.J., Morley C.P., Kennedy J.L., Azevedo M.H., Daly M.J., and Sklar P. Genome-wide scan in Portuguese island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11. Am. J. Med. Genet. B Neuropsychiatr. Genet. 127 (2004) 30-34
44. Purba J.S., Hoogendijk W.J.G., Hofman M.A., and Swaab D.F. Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch. Gen. Psychiatry 53 (1996) 137-143
45. Rucinski M., Andreis P.G., Ziolkowska A., Nussdorfer G.G., and Malendowicz L.K. Differential expression and function of beacon in rat adrenal cortex and medulla. Int. J. Mol. Med. 16 (2005) 35-40
46. Rucinski M., Spinazzi R., Ziolkowska A., Nussdorfer G.G., and Malendowicz L.K. Effects of beacon on the rat pituitary-adrenocortical axis response to stress. Int. J. Mol. Med. 16 (2005) 297-299
47. Sacks F.M. Metabolic syndrome: epidemiology and consequences. J. Clin. Psychiatry 18 (2004) 3-12
48. Schröder H., Grecksch G., Becker A., Bogerts B., and Höllt V. Alterations of the dopaminergic and glutamatergic neurotransmission in adult rats with postnatal ibotenic acid hippocampal lesion. Psychopharmacology 145 (1999) 61-66
49. Schulz C., Paulus K., and Lehnert H. Central nervous and metabolic effects of intranasally applied leptin. Endocrinology 145 (2004) 2696-2701
50. Thakore J.H. Metabolic disturbances in first-episode schizophrenia. Br. J. Psychiatry Suppl. 47 (2004) S76-S79
51. Thakore J.H., Mann J.N., Vlahos I., Martin I., and Reznek R. Increased visceral fat distribution in drug-naïve and drug-free patients with schizophrenia. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 137-141
52. Tirupati, S., Chua, L.-E., 2007. Body mass index as a screening test for metabolic syndrome in schizophrenia and schizoaffective disorders. Australas. Psychiatry. doi:10.1080/10398560701639606.
53. Walder K., Ziv E., Kalman R., Whitecross K., Shafrir E., Zimmet P., and Collier G.R. Elevated hypothalamic beacon in Psammomys obesus prone to develop obesity and type 2 diabetes. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 605-609
54. Wang F., Tian I.R., Chen H., Shi X.S., Chang J.K., Yang J., Yuan L., and Han J.S. Distribution of beacon immunoreactivity in the rat brain. Peptides 27 (2006) 165-171
55. Weiden P.J., Mackell J.A., and McDonnell D.D. Obesity as a risk for antipsychotic non-compliance. Schizophr. Res. 66 (2004) 51-57
56. Yamada Y., Esaki Y., and Mizutani T. Intracranial cavity volume can be accurately estimated from the weights of intracranial contents: confirmation by the dental plaster casting method. Neuropathol. Appl. Neurobiol. 25 (1999) 341-344
57. Yeap S., and Thakore J.H. Stress axis dysfunction in schizophrenia. Eur. Psychiatry Suppl. 3 (2005) S307-S312
58. Ziolkowska A., Rucinski M., Di Liddo R., Nussdorfer G.G., and Malendowicz L.K. Expression of the beacon gene in endocrine glands of the rat. Peptides 25 (2004) 133-137