Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid

Neurobiology of Disease

Volumn 29, Issue 3, 2008, Pages 391-399

  McLin, Jessica Pilar ^a,b   Thompson, Leslie Michels ^b   Lusis, Aldons J ^c   Davis, Richard C ^c   Steward, Oswald ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Epilepsy; Genome tagged mice; Hippocampus; Huntington's disease; Kainic acid

Indexed keywords

KAINIC ACID; QUINOLINIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 18; CONGENIC STRAIN; EPILEPTIC STATE; EXCITOTOXICITY; GENE; GENETIC SUSCEPTIBILITY; MALE; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; STRIATONIGRAL DEGENERATION;

ANIMALS; CHROMOSOMES, MAMMALIAN; CORPUS STRIATUM; DISEASE SUSCEPTIBILITY; EXCITATORY AMINO ACID AGONISTS; MALE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, INBRED DBA; NERVE DEGENERATION; QUINOLINIC ACID; SPECIES SPECIFICITY; STATUS EPILEPTICUS;

EID: 39149137852     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.10.002     Document Type: Article

References (21)

1. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14 (1985) 375-403
2. Ben-Ari Y., Tremblay E., and Ottersen O.P. Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical, and histological study in relation to the oathology of epilepsy. Neuroscience 5 (1980) 515-528
3. Davis R.C., Schadt E.E., Smith D.J., Hsieh E.W., Cervino A.C., van Nas A., Rosales M., Doss S., Meng H., Allyee H., and Lusis A.J. A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6 background. Genomics 86 (2005) 259-270
4. Engstrom F.L., and Woodbury D.M. Seizure susceptibility in DBA and C57 mice: the effects of various convulsants. Epilepsia 29 (1988) 389-395
5. Ferraro T.N., Golden G.T., Smith G.G., and Berrettini W.H. Differential susceptibility to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice. Epilepsia 36 (1995) 301-307
6. Ferraro T.N., Golden G.T., Smith G.G., Schork N.J., St. Jean P., Ballas C., Choi H., and Berrettini W.H. Mapping murine loci for seizure response to kainic acid. Mamm. Genome 8 (1997) 200-208
7. Golden G.T., Ferraro T.N., Smith G.G., Snyder R.L., Jones N.L., and Berrettini W.H. Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains. Neuropsychopharmacology 24 (2001) 291-299
8. Iakoubova O.A., Olsson C.L., Dains K.M., Ross D.A., Andalibi A., Lau K., Choi J., Kalcheva I., Cunanan M., Louie J., Nimon V., Machrus M., Bentely L.G., Beauheim C., Silvey S., Cavalcoli J., Aldons J.L., and West D.B. Genome-tagged mice (GTM): two sets of genome-wide congenic strains. Genomics 74 (2001) 89-104
9. Lorenzana A., Chancer Z., and Schauwecker P.E. A quantitative trait locus on chromosome 18 is a critical determinant of excitotoxic cell death susceptibility. Eur. J. Neurosci. 25 (2007) 1998-2008
10. McLin J.P., and Steward O. Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. Eur. J. Neurosci. 24 (2006) 2191-2202
11. McLin J.P., Thompson L.M., and Steward O. Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred, and hybrid mouse strains. Eur. J. Neurosci. 24 (2006) 3134-3140
12. Racine R. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32 (1972) 281-294
13. Schauwecker P.E. Complications associated with genetic background effects in models of experimental epilepsy. Prog. Brain Res. 135 (2002) 139-148
14. Schauwecker P.E. Genetic basis of kainate-induced excitotoxicity in mice: phenotypic modulation of seizure-induced cell death. Epilepsy Res. 55 (2003) 201-210
15. Schauwecker P.E. Susceptibility to excitotoxic and metabolic striatal neurodegeneration in the mouse is genotype dependent. Brain Res. 1040 (2005) 112-120
16. Schauwecker P.E., and Steward O. Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 4103-4108
17. Schauwecker P.E., Williams R.W., and Santos J.B. Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. J. Comp. Neurol. 477 (2004) 96-107
18. Schmued L.C., and Hopkins K.J. Fluoro-jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874 (2000) 123-130
19. Schmued L.C., and Hopkins K.J. Fluoro-jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol. Pathol. 28 (2000) 91-99
20. Schmued L.C., Albertson C., and Slikker W. Fluoro-jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751 (1997) 37-46
21. Sperk G., Lassmann H., Baran H., Kish S.J., Seitelberger F., and Hornykiewicz O. Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10 (1983) 1301-1315