Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation

Infection and Immunity

Volumn 76, Issue 2, 2008, Pages 632-638

  Mulcahy, Heidi ^a,d   O'Callaghan, Julie ^a   O'Grady, Eoin P ^a,d   Maciá, María D ^b   Borrell, Nuria ^b   Gómez, Cristina ^b   Casey, Pat G ^c   Hill, Colin ^c   Adams, Claire ^a   Gahan, Cormac G M ^a,c   Oliver, Antonio ^b   O'Gara, Fergal ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d Health Sciences Centre Calgary   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; RSMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; GENE MUTATION; LOBAR PNEUMONIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA;

ANIMALS; FEMALE; GENE DELETION; MICE; MICE, INBRED BALB C; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TRANSCRIPTION FACTORS; VIRULENCE; VIRULENCE FACTORS;

EID: 39149118930     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01132-07     Document Type: Article

References (39)

1. Burns, J. L., R. L. Gibson, S. McNamara, D. Yim, J. Emerson, M. Rosenfeld, P. Hiatt, K. McCoy, R. Castile, A. L. Smith, and B. W. Ramsey. 2001. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J. Infect. Dis. 183:444-452.
2. Burrowes, E., A. Abbas, A. O'Neill, C. Adams, and F. O'Gara. 2005. Characterisation of the regulatory RNA RsmB from Pseudomonas aeruginosa PAO1. Res. Microbiol. 156:7-16.
3. Burrowes, E., C. Baysse, C. Adams, and F. O'Gara. 2006. Influence of the regulatory protein RsmA on cellular functions in Pseudomonas aeruginosa PAO1, as revealed by transcriptome analysis. Microbiology 152:405-418.
4. Choi, K. H., J. B. Gaynor, K. G. White, C. Lopez, C. M. Bosio, R. R. Karkhoff-Schweizer, and H. P. Schweizer. 2005. A Tn7-based broad-range bacterial cloning and expression system. Nat. Methods 2:443-448.
5. Chopra, I., A. J. O'Neill, and K. Miller. 2003. The role of mutators in the emergence of antibiotic-resistant bacteria. Drug Resist. Updates 6:137-145.
6. Comolli, J. C., A. R. Hauser, L. Waite, C. B. Whitchurch, J. S. Mattick, and J. N. Engel. 1999. Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia. Infect. Immun. 67:3625-3630.
7. Dacheux, D., I. Attree, and B. Toussaint. 2001. Expression of ExsA in trans confers type III secretion system-dependent cytotoxicity on noncytotoxic Pseudomonas aeruginosa cystic fibrosis isolates. Infect. Immun. 69:538-542.
8. Deretic, V., M. J. Schurr, and H. Yu. 1995. Pseudomonas aeruginosa, mucoidy and the chronic infection phenotype in cystic fibrosis. Trends Microbiol. 3:351-356.
9. Ernst, R. K., D. A. D'Argenio, J. K. Ichikawa, M. G. Bangera, S. Selgrade, J. L. Burns, P. Hiatt, K. McCoy, M. Brittnacher, A. Kas, D. H. Spencer, M. V. Olson, B. W. Ramsey, S. Lory, and S. I. Miller. 2003. Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis. Environ. Microbiol. 5:1341-1349.
10. Freeman, R., H. Geier, K. M. Weigel, J. Do, T. E. Ford, and G. A. Cangelosi. 2006. Roles for cell wall glycopeptidolipid in surface adherence and planktonic dispersal of Mycobacterium avium. Appl. Environ. Microbiol. 72:7554-7558.
11. Friedman, L., and R. Kolter. 2004. Genes involved in matrix formation in Pseudomonas aeruginosa PA14 biofilms. Mol. Microbiol. 51:675-690.
12. Furukawa, S., S. L. Kuchma, and G. A. O'Toole. 2006. Keeping their options open: acute versus persistent infections. J. Bacteriol. 188:1211-1217.
13. Goldberg, J. B., and G. B. Pler. 1996. Pseudomonas aeruginosa lipopolysaccharides and pathogenesis. Trends Microbiol. 4:490-494.
14. Goodman, A. L., B. Kulasekara, A. Rietsch, D. Boyd, R. S. Smith, and S. Lory. 2004. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev. Cell 7:745-754.
15. Hentzer, M., G. M. Teitzel, G. J. Balzer, A. Heydorn, S. Molin, M. Givskov, and M. R. Parsek. 2001. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function. J. Bacteriol. 183:5395-5401.
16. Heurlier, K., F. Williams, S. Heeb, C. Dormond, G. Pessi, D. Singer, M. Camara, P. Williams, and D. Haas. 2004. Positive control of swarming, rhamnolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeruginosa PAO1. J. Bacteriol. 186: 2936-2945.
17. Jain, M., D. Ramirez, R. Seshadri, J. F. Cullina, C. A. Powers, G. S. Schulert, M. Bar-Meir, C. L. Sullivan, S. A. McColley, and A R. Hauser. 2004. Type III secretion phenotypes of Pseudomonas aeruginosa strains change during infection of individuals with cystic fibrosis. J. Clin. Microbiol. 42:5229-5237.
18. Johansen, H. K., F. Espersen, S. J. Cryz, Jr., H. P. Hougen, A. Fomsgaard, J. Rygaard, and N. Hoiby. 1994. Immunization with Pseudomonas aeruginosa vaccines and adjuvant can modulate the type of inflammatory response subsequent to infection. Infect. Immun. 62:3146-3155.
19. Kay, E., B. Humair, V. Denervaud, K. Riedel, S. Spahr, L. Eberl, C. Valverde, and D. Haas. 2006. Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa. J. Bacteriol. 188: 6026-6033.
20. Labat, F., O. Pradillon, L. Garry, M. Peuchmaur, B. Fantin, and E. Denamur. 2005. Mutator phenotype confers advantage in Escherichia coli chronic urinary tract infection pathogenesis. FEMS Immunol. Med. Microbiol. 44:317-321.
21. Laskowski, M. A., E. Osborn, and B. I. Kazmierczak. 2004. A novel sensor kinase-response regulator hybrid regulates type III secretion and is required for virulence in Pseudomonas aeruginosa. Mol. Microbiol. 54:1090-1103.
22. Lujan, A. M., A. J. Moyano, I. Segura, C. E. Argarana, and A. M. Smania. 2007. Quorum-sensing-deficient (lasR) mutants emerge at high frequency from a Pseudomonas aeruginosa mutS strain. Microbiology 153:225-237.
23. Luzar, M. A., and T. C. Montie. 1985. Avirulence and altered physiological properties of cystic fibrosis strains of Pseudomonas aeruginosa. Infect. Immun. 50:572-576.
24. Macia, M. D., N. Borrell, M. Segura, C. Gomez, J. L. Perez, and A. Oliver. 2006. Efficacy and potential for resistance selection of antipseudomonal treatments in a mouse model of lung infection by hypermutable Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 50:975-983.
25. Mahenthiralingam, E., M. E. Campbell, and D. P. Speert. 1994. Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect. Immun. 62:596-605.
26. Mena, A., M. D. Macia, N. Borrell, B. Moya, T. de Francisco, J. L. Perez, and A. Oliver. 2007. Inactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis mice. J. Bacteriol. 189:3665-3668.
27. Mukherjee, A., Y. Cui, W. Ma, Y. Liu, and A. K. Chatterjee. 2000. hexA of Erwinia carotovora ssp. carotovora strain Ecc71 negatively regulates production of RpoS and rsmB RNA, a global regulator of extracellular proteins, plant virulence and the quorum-sensing signal, N-(3-oxohexanoyl)-L- homoserine lactone. Environ. Microbiol. 2:203-215.
28. Mulcahy, H., J. O'Callaghan, E. P. O'Grady, C. Adams, and F. O'Gara. 2006. The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system. Infect. Immun. 74:3012-3015.
29. O'Grady, E. P., H. Mulcahy, J. O'Callaghan, C. Adams, and F. O'Gara. 2006. Pseudomonas aeruginosa infection of airway epithelial cells modulates expression of Kruppel-like factors 2 and 6 via RsmA-mediated regulation of type III exoenzymes S and Y. Infect. Immun. 74:5893-5902.
30. Oliver, A., F. Baquero, and J. Blazquez. 2002. The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants. Mol. Microbiol. 43:1641-1650.
31. Oliver, A., R. Canton, P. Campo, F. Baquero, and J. Blazquez. 2000. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 288:1251-1254.
32. Pessi, G., F. Williams, Z. Hindle, K. Heurlier, M. T. Holden, M. Camara, D. Haas, and P. Williams. 2001. The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa. J. Bacteriol. 183:6676-6683.
33. Ramsey, B. W., M. S. Pepe, J. M. Quan, K. L. Otto, A. B. Montgomery, J. Williams-Warren, K. M. Vasiljev, D. Borowitz, C. M. Bowman, B. C. Marshall, S. Marshall, and A. L. Smith. 1999. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N. Engl. J. Med. 340:23-30.
34. Riedel, C. U., P. G. Casey, H. Mulcahy, F. O'Gara, C. G. M. Gahan, and C. Hill. 2007. Construction of p16Slux, a novel vector for improved bioluminescent-labeling of gram-negative bacteria. Appl. Environ. Microbiol. 73: 7092-7095.
35. van Heeckeren, A. M., and M. D. Schluchter. 2002. Murine models of chronic Pseudomonas aeruginosa lung infection. Lab. Anim. 36:291-312.
36. Ventre, I., A. L. Goodman, I. Vallet-Gely, P. Vasseur, C. Soscia, S. Molin, S. Bleves, A. Lazdunski, S. Lory, and A. Filloux. 2006. Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes. Proc. Natl. Acad. Sci. USA 103:171-176.
37. Yahr, T. L., and E. P. Greenberg. 2004. The genetic basis for the commitment to chronic versus acute infection in Pseudomonas aeruginosa. Mol. Cell 16:497-498.
38. Yahr, T. L., and M. C. Wolfgang. 2006. Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 62:631-640.
39. Zolfaghar, I., D. J. Evans, R. Ronaghi, and S. M. Fleiszig. 2006. Type III secretion-dependent modulation of innate immunity as one of multiple factors regulated by Pseudomonas aeruginosa RetS. Infect. Immun. 74:3880-3889.