Expression of ExsA in trans confers type III secretion system-dependent cytotoxicity on noncytotoxic Pseudomonas aeruginosa cystic fibrosis isolates

Infection and Immunity

Volumn 69, Issue 1, 2001, Pages 538-542

  Dacheux, D ^a   Attree, I ^a   Toussaint, B ^a  

^a CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CYSTIC FIBROSIS; CYTOTOXICITY; GENE EXPRESSION; OPERON; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN SECRETION; PSEUDOMONAS AERUGINOSA; REGULON; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; CYSTIC FIBROSIS; DNA-BINDING PROTEINS; HUMANS; MACROPHAGES; NEUTROPHILS; OPERON; PSEUDOMONAS AERUGINOSA; TRANS-ACTIVATORS;

EID: 0035173475     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.1.538-542.2001     Document Type: Article

References (29)

1. FACS-optimized mutants of the green fluorescent protein (GFP)
2. Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system
3. Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophils
4. Cystic fibrosis. 2. Lung injury in cystic fibrosis
5. Electroporation of freshly plated Escherichia coli and Pseudomonas aeruginosa cells
6. ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury
7. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa
8. Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments
9. Functional analysis of ExsC and ExsB in regulation of exoenzyme S production by Pseudomonas aeruginosa
10. Microbial pathogenesis in cystic fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia cepacia
11. PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence
12. Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon
13. Type III protein secretion systems in bacterial pathogens of animals and plants
14. Type III secretion systems: Machines to deliver bacterial proteins into eukaryotic cells?
15. Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients
16. Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor
17. Modification of Ras in eukaryotic cells by Pseudomonas aeruginosa exoenzyme S
18. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line
19. Interruption of multiple cellular processes in HT-29 epithelial cells by Pseudomonas aeruginosa exoenzyme S
20. Effects of differential expression of the 49-kilodalton exoenzyme S by Pseudomonas aeruginosa on cultured eukaryotic cells
21. The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins
22. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
23. Pseudomonas aeruginosa contains an IHF-like protein that binds to the algD promoter
24. Construction of improved Escherichia-Pseudomonas shuttle vectors derived from pUC18/19 and sequence of the region required for their replication in Pseudomonas aeruginosa
25. Transcriptional organization of the trans-regulatory locus which controls exoenzyme S synthesis in Pseudomonas aeruginosa
26. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway
27. Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene
28. ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system