Khat (Catha edulis) lowers plasma luteinizing hormone (LH) and testosterone secretion, but increases cortisol levels in male rabbits

Journal of Ethnopharmacology

Volumn 116, Issue 2, 2008, Pages 245-250

  Nyongesa, A W ^a   Patel, N B ^a   Onyango, D W ^a   Odongo, H O ^a   Wango, E O ^a  

^a UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

Cortisol; Khat; Luteinizing hormone; Rabbits; Testosterone

Indexed keywords

CATHA EDULIS EXTRACT; HYDROCORTISONE; LUTEINIZING HORMONE; PLANT EXTRACT; SEX HORMONE; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CATHA EDULIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; HYDROCORTISONE BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MALE; MOUSE; NONHUMAN; PULSE RATE; RABBIT; RADIOIMMUNOASSAY; REPRODUCTION; REPRODUCTIVE TOXICITY; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE;

ANIMALS; CATHA; HYDROCORTISONE; LUTEINIZING HORMONE; MALE; MICE; PLANT EXTRACTS; RABBITS; RADIOIMMUNOASSAY; TESTOSTERONE;

ANIMALIA; CATHA EDULIS; ORYCTOLAGUS CUNICULUS;

EID: 39149105958     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.11.022     Document Type: Article

References (47)

1. Adeoya-Osiguwa S.A., and Fraser L.R. Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss. Human Reproduction 20 (2005) 198-207
2. Akana S.F., Casio C.S., Du J.Z., Levin N., and Dallman M.F. Reset of feedback in the adrenocortical system: an apparent shift in sensitivity of adrenocorticotrophin to inhibition by corticosterone between morning and evening. Endocrinology 119 (1996) 2325-2332
3. Albers D.S., and Sonsall P.K. Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and non-protective agents. Journal of Pharmacology and Experimental Therapeutics 275 (1995) 1104-1114
4. Al-Meshal I.A. Mitodepressive effects of (-)-cathinone from khat (Catha edulis) on the meristematic region of Allium cepa root tips. Journal of the International Society on Toxinology 25 (1987) 451-454
5. Al-Meshal I.A., Qureshi S., El-Feraly F.S., and Tariq M. The toxicity of (-)-cathinone from Catha edulis on prolonged treatment in Swiss mice. Proceedings of the 35th International Congress on Alcoholism and Drug Dependence, vol. 1. Oslo, Norway (1989) 64
6. Al-Motarreb A., Baker K., and Broadley K.J. Khat: Pharmacological and medical aspects and its social use in Yemen. Phytotherapy Research 16 (2002) 403-413
7. Baasher T.A. The use of khat: a stimulant with regional distribution. In: Edwards G., and Arif A. (Eds). Drug Problems in the Socio-cultural Context. A Basis for Policies and Programme Planning (1980), World Health Organization, Geneva 86-93
8. Balint G.A., Ghebrekidan H., and Balint E. Catha edulis: an international socio-medical problem with considerable pharmacological implications. East African Medical Journal 68 (1991) 555-561
9. Brenneisen R., Fisc H.U., Koelbing U., Geisshüsler S., and Kalix P. Amphetamine-like effects in humans of the khat alkaloid cathinone. British Journal of Clinical Pharmacology 30 (1990) 825-828
10. Calcagnetti D.J., and Schechter M.D. Place preference for the psychostimulant-cathinone is blocked by pretreatment with a dopamine release inhibitor. Progress in Neuro-psychopharmacology and Biological Psychiatry 17 (1993) 637-649
11. De Hondt H.A., Fahmy A.M., and Abdelbaset S.A. Chromosomal and biochemical studies on the effect of khat extract on laboratory rats. Environmental Mutagenesis 6 (1984) 851-860
12. Elmi A.S. The chewing of khat in Somalia. Journal of Ethnopharmacology 8 (1983) 163-176
13. Halbreich U., Sachar E.J., Asnis G.M., Nathan R.S., and Halpern F.S. Diurnal cortisol responses to dextroamphetamine in normal subjects. Psychoneuroendocrinology 6 (1981) 223-229
14. Hall P.F. Testicular steroid synthesis: organization and regulation. Physiology and Reproduction 2 (1994) 1335-1362
15. Hammouda E.S. Effect of khat extract, D-cycloserine and thiadomide on RNA of the neurons of 7 and 19 days of chick embryo. Bulletin of Sciences 3 (1971) 64
16. Islam M.W., Tariq M., Ageel A.M., El-Feraly F.S., Al-Meshal I.A., and Ashaf I. An evaluation of the male reproductive toxicity of cathinone. Toxicology 603 (1990) 223-234
17. Jacobs D., Silverstone T., and Rees L. The neuroendocrine response to oral dextroamphetamine in normal subjects. International Clinical Psychopharmacology 4 (1989) 135-147
18. Kaira P.S., Sahu A., and Karl S.P. Interleukin 1 inhibits the ovarian steroid, induces LH surge and release of hypothalamus LHRH in rats. Endocrinology 126 (1990) 2145-2152
19. Kalix P. Cathinone: an alkaloid from khat leaves with an amphetamine-like releasing effect. Psychopharmacology 74 (1981) 269-270
20. Kalix P. The amphetamine-like releasing effect of alkaloid (-) cathinone on rat nucleus accumbens and rabbit caudate nucleus. Progress in Neuro-psychopharmacology and Biological Psychiatry 6 (1982) 43-49
21. Kalix P. The pharmacology of khat. General Pharmacology 15 (1984) 179-187
22. Kalix P. Khat: a plant with amphetamine effects. Journal of Substance Abuse Treatment 5 (1988) 163-169
23. Kalix P. The pharmacology of psychoactive alkaloids from ephedra and catha. Journal of Ethnopharmacology 32 (1991) 201-208
24. Kalix P. Cathinone: a natural amphetamine. Pharmacological Toxicology 70 (1992) 77-86
25. Kalix P., and Braenden O. Pharmacological aspects of the chewing of khat leaves. Pharmacological Reviews 37 (1985) 149-164
26. Kalix P., and Glennon G. Further evidence for an amphetamine-like mechanism of action of the alkaloid cathinone. Biomedical Pharmacology 35 (1986) 3015-3019
27. Kalix P., Taha S.A., Ageel A.M., Islam M.W., and Ginawi O.T. Effect of (-)-cathinone, a psychoactive alkaloid from khat (Catha edulis Forsk) and caffeine on sexual behaviour in rats. Pharmacology Research 31 (1995) 299-303
28. Luqman W., and Danowski T.S. The use of khat (Catha edulis) in Yemen: social and medical observations. Annals of Internal Medicine 85 (1976) 246-249
29. Marinelli M., and Piazza P.V. Interaction between glucocorticoid hormones, stress and psychostimulant drugs. European Journal of Neuroscience 16 (2002) 387-394
30. Marquette C., Ban E., Fillon G., and Haour F. Receptors for interleukin 1, 2 and 6 in mouse, rat and human pituitary. Neuroendocrinology 52 (1990) 48
31. Mello N.K., and Mendelson J.H. Cocaine's effects on neuroendocrine systems: clinical and preclinical studies. Pharmacology Biochemistry and Behaviour 57 (1997) 571-599
32. Mwenda J.M., Owuor R.A., Kyama C.M., Wango E.O., Arimi M.M., and Langat D.K. Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboon. Journal of Ethnopharmacology 103 (2006) 379-384
33. Nencini P., Anania M.A., Abdulhi A.M., Amiconi G., and Elmi A.S. Physiological and neuroendocrine effects of khat in man. International Conference on Khat. The Health and Socioeconomic Aspects of Khat Use. International Council on Alcohol and Addictions, Madagascar (1983) 148-152
34. Nyongesa A.W., Patel N.B., Onyango D.W., Wango E.O., and Odongo H.O. In vitro study of the effects of khat (Catha edulis Forsk) extract on isolated mouse interstitial cells. Journal of Ethnopharmacology 110 (2007) 401-405
35. Parmar N.S., and Tariq M. Studies on endocrine disturbances induced by chronic khat (Catha edulis Forsk) administration in albino rats. Sixth European Symposium on Animals and Microbial Toxins. Basle, August (1984) 27-31
36. Patel N.B. Mechanism of action of cathinone: the active ingredient of khat (Catha edulis). East African Medical Journal 77 (2000) 329-332
37. Scarborough D.E. Cytokine modulation of pituitary hormone secretion. Annals of New York Academy of Science 594 (1990) 169-187
38. Schad C.A., Justice J.B., and Holtzman S.G. Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. Journal of Pharmacology and Experimental Therapeutics 300 (2002) 932-938
39. 2 autoreceptors, transporters and synaptic vesicle stores. Journal of Neuroscience 21 (2001) 5916-5924
40. Smith S.M., Vaughan J.M., Donaldson C.J., Rivier J., Li C., and Chen A. Cocaine and amphetamine-regulated transcript activates the hypothalamic-pituitary-adrenal axis through a corticotrophin-releasing factor receptor-dependent mechanism. Endocrinology 145 (2004) 5202-5209
41. Sufi S.B., Donaldson A., and Jeffcoate S.L. World Health Organization Matched Reagent Programme Method Manual. 17th ed. (1996), WHO, Geneva
42. Swerdlow N.R., Koob G.F., Cador M., Lorang M., and Hauger R.L. Pituitary-adrenal axis responses to acute amphetamine in the rat. Pharmacology Biochemistry and Behaviour 45 (1993) 629-637
43. Tariq M., Parmar S., Qureshi S., El-Feraly F.S., and Al-Meshal I.A. Clastogenic evaluation of cathinone and amphetamine in somatic cells of mice. Mutation Research 190 (1987) 153
44. Wagner G., Preston K., Ricuarte G., Schuster C., and Seiden L. Neurochemical similarities between d-1-cathinone and d-amphetamine. Drug and Alcohol Dependence 9 (1982) 279-284
45. Wango E.O., Odongo H.O., Oduma J., and Oduor-Okelo D. Effects of 6-hydroxydopamine on testosterone production by mouse Leydig cells in vitro. Acta Biologica Hungarica 46 (1995) 75-85
46. Yang N.Y., Kaphle K., Wang P.H., Jong D.S., Wu L.S., and Lin H.H. Effects of aqueous extracts of "Betel quid" and its constituents on testosterone production by dispersed mouse interstitial cells. American Journal of Chinese Medicine 32 (2004) 705-715
47. Yen S.S. The hypothalamic control of pituitary hormone secretion. In: Yen S.S., and Jaffe R.B. (Eds). Reproductive Endocrinology (1991), Saunders, W.B. Company 65-104