Clinical Significance of Low Level Human Chorionic Gonadotropin in the Management of Testicular Germ Cell Tumor

Journal of Urology

Volumn 179, Issue 3, 2008, Pages 930-935

  Takizawa, Akitoshi ^a   Kishida, Takeshi ^a   Miura, Takeshi ^b   Hattori, Yusuke ^a   Noguchi, Kazumi ^a   Kubota, Yoshinobu ^c  

^a YOKOHAMA CITY UNIVERSITY MEDICAL CENTER   (Japan)

^b KANAGAWA CANCER CENTER   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

biological; chorionic gonadotropin; false positive reactions; testicular neoplasms; testis; tumor markers

Indexed keywords

CHORIONIC GONADOTROPIN;

ADULT; ALGORITHM; ARTICLE; CANCER THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FALSE POSITIVE RESULT; GERM CELL TUMOR; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; LABORATORY DIAGNOSIS; MALE; MEDICAL EXAMINATION; PHYSICIAN; PRIORITY JOURNAL; TESTIS CANCER; TROPHOBLASTIC TUMOR; TUMOR CLASSIFICATION; URINALYSIS;

ADULT; ALGORITHMS; BIOLOGICAL MARKERS; CHORIONIC GONADOTROPIN; FALSE POSITIVE REACTIONS; HUMANS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; TESTICULAR NEOPLASMS;

EID: 39149088950     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2007.11.008     Document Type: Article

References (13)

1. Doherty A.P., Bower M., and Christmas T.J. The role of tumour markers in the diagnosis and treatment of testicular germ cell cancers. Br J Urol 79 (1997) 247
2. Lamerz R. Alpha-fetoprotein. In: Thomas L. (Ed). Clinical Laboratory Diagnostics (1998), TH-Books, Frankfurt am Main 941
3. Saller B., Clara R., Spottl G., Siddle K., and Mann K. Testicular cancer secretes intact human choriogonadotropin (HCG) and its free β-subunit: evidence that HCG (+HCG-β) assays the most reliable in diagnosis and follow-up. Clin Chem 36 (1990) 234
4. Rotmensch S., and Cole L.A. False diagnosis and needless therapy of presumed malignant disease in women with false-positive human chorionic gonadotropin concentrations. Lancet 355 (2000) 712
5. Cole L.A., and Khanlian S.A. Inappropriate management of women with persistent low hCG results. J Reprod Med 49 (2004) 423
6. Kohorn E.I. What we know about low level hCG: definition, classification and management. J Reprod Med 49 (2004) 433
7. Trojan A., Joller-Jemelka H., Stahel R.A., Jacky E., and Hersberger M. False-positive human serum chorionic gonadotropin in a patient with a history of germ cell cancer. Oncology 66 (2004) 336
8. Hattori Y., Takizawa A., Kishida T., Fujikawa N., Teranishi J., Kondo K., et al. A case of seminoma with a low level positive of serum hCG (human chorionic gonadotropin) beta considered as false positive hCG beta. Nippon Hinyokika Gakkai Zasshi 97 (2006) 804
9. Cole L.A., Khanlian S.A., Giddings A., Butler S.A., Muller C.Y., Hammond C., et al. Gestational trophoblastic diseases: 4. Presentation with persistent low positive human chorionic gonadotropin test results. Gynecol Oncol 102 (2006) 165
10. Marcillac I., Troalen F., Bidart J.M., Ghillani P., Ribrag V., Escudier B., et al. Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms. Cancer Res 52 (1992) 3901
11. Khanlian S.A., Smith S.O., and Cole L.A. Persistent low levels of human chorionic gonadotropin: a premalignant gestational trophoblastic disease. Am J Obset Gynecol 188 (2003) 1254
12. Khanlian S.A., and Cole L.A. Management of gestational trophoblastic disease and other cases with low serum levels of human chorionic gonadotropin. J Reprod Med 51 (2006) 812
13. Birken S., Maydelman Y., Gawinowicz M.A., Pound A., Liu Y., and Hartree A.S. Isolation and characterization of human pituitary chorionic gonadotropin. Endocrinology 137 (1996) 1402