Preliminary results of interferon alpha-2a and lamivudine combination therapy regimen in children with chronic hepatitis B;Kronik hepatit B tanιsι alan çocuklarda interferon-alfa 2a ve lamivudin kombinasyonu tedavisinin erken dönem sonuçlarι

Mikrobiyoloji Bulteni

Volumn 40, Issue 1-2, 2006, Pages 47-53

  Aşik Akman, Sezin ^a   Çokçeken Okçu, Sabriye ^a   Halicioǧlu, Oya ^a   Anil, Murat ^a   Köse, Şükran ^b   Bakiler, Ali Rahmi ^a  

^a TEPECIK EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b Tepecik E itim ve Ara tirma Hastanesi   (Turkey)

Author keywords

Childhood; Chronic hepatitis B; Combination therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA2A INTERFERON; ANTIVIRUS AGENT; HEPATITIS B ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; VIRUS DNA;

ADOLESCENT; ARTICLE; BLOOD; CHILD; DRUG COMBINATION; FEMALE; GENETICS; HEPATITIS B; HUMAN; IMMUNOLOGY; MALE; PRESCHOOL CHILD; PROSPECTIVE STUDY; TREATMENT OUTCOME;

ADOLESCENT; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; DRUG THERAPY, COMBINATION; FEMALE; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; INTERFERON ALFA-2A; LAMIVUDINE; MALE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 39049195118     PISSN: 03749096     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Lai CL, Ratziu V, Yuen MF, et al. Viral hepatitis B. Lancet 2003; 362: 2089-94.
2. Papatheodoridis GV, Hadziyannis SJ. Current management of chronic hepatitis B. Aliment Pharmacol Ther 2004; 19: 25-37.
3. Gurakan F, Kocak N, Ozen H, Yuce A. Comparison of stanclart and high dosage recombinant interferon alpha 2b for treatment of children with chronic hepatitis B infection. Pediatr Infect Dis 2000; 19: 52-6.
4. Mutimer D, Dowling D, Cane P, et al. Additive antiviral effects of lamivudine and alpha-interferon in chronic hepatitis B infection. Antivir Ther 2000; 5: 273-7.
5. Korba BE, Cote P, Hornbuckle W, et al. Enhanced antiviral benefit of combination therapy with lamivudine and alpha interferon against WHV replication in chronic carrier woodchucks. Antivir Ther 2000; 5: 95-104.
6. Taşyaran M. HBV infeksiyonu epiclemiyolojisi, s: 121-8. Tekeli E, Balik I (ed), Viral Hepatit 2002. 2002, 1.baski. Viral Hepatitle Savaşim Derneǧi, Ankara.
7. Barbaro G, Zechini F, Pellicelli AM, et al. and Lamivudine Italian Study Group Investigators. Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monotherapy in patients with chronic hepatitis B. An Italian multicenter, randomized trial. J Hepatol 2001; 35: 406-11.
8. Jang MK, Chung YH, Choi MH, et al. Combination of alpha-interferon with lamivudine reduces viral breakthrough during long-term therapy. J Gastroenterol Hepatol 2004; 19: 1363-8.
9. Schalm SW, Heathcote J, Cianciara J, et al. Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial. Gut 2000; 46: 562-8.
10. Dikici B, Bosnak M, Bosnak V, et al. Combination therapy for children with chronic hepatitis B virus infection. J Gastroenterol Hepatol 2002; 17: 1087-91.
11. Saltik Temizel IN, Koçak N, Demir H. Lamivudine and high-dose interferon-alpha combination therapy for naive children with chronic hepatitis B infection. J Clin Gastroenterol 2005; 39: 68-70.
12. Dikici B, Bosnak M, Bosnak V, et al. Comparison of treatments of chronic hepatitis B in children with lamivudine and alpha-interferon combination and alpha-interferon alone. Pediatr Int 2002; 44: 517-21.
13. Leung N. Treatment of chronic hepatitis B: case selection and duration of therapy. J Gastroenterol Hepatol 2002; 17: 409-14.
14. Janssen HL, Gerken G, Carreno V, et al. Interferon alpha for chronic hepatitis B infection: increased efficacy of prolonged treatment. The European Concerted Action on Viral Hepatitis (EUROHEP). Hepatology 1999; 30: 238-43.
15. Simon K, Retter K, Zalewska M. HBV-DNA level in blood serum as a predictor of good response to therapy with interferon-alpha 2b of patients with chronic hepatitis B. Med Sci Monitor 2000; 6: 971-5.
16. Ozgenc F, Dikici B, Targan S, et al. Comparison of antiviral effect of lamivudine with interferon-alpha 2a versus -alpha 2b in children with chronic hepatitis B infection. Antivir Ther 2004; 9: 23-6.
17. Hartman C, Berkowitz D, Shouval D, et al. Lamivudine treatment for chronic hepatitis B infection in children unresponsive to interferon. Pediatr Infect Dis J 2003; 22: 224-8.