Combination of α-interferon with lamivudine reduces viral breakthrough during long-term therapy

Journal of Gastroenterology and Hepatology (Australia)

Volumn 19, Issue 12, 2004, Pages 1363-1368

  Jang, Myoung Kuk ^a   Chung, Young Hwa ^a   Choi, Min Hee ^a   Kim, Jeong A ^a   Ryu, Soo Hyung ^a   Shin, Jung Woo ^a   Kim, In Sook ^a   Park, Neung Hwa ^a   Lee, Han Chu ^a   Lee, Yung Sang ^a   Suh, Dong Jin ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Chronic hepatitis B; Interferon; Lamivudine; Viral breakthrough

Indexed keywords

ALPHA INTERFERON; HEPATITIS B(E) ANTIGEN; LAMIVUDINE;

ABDOMINAL PAIN; ADULT; ANTIVIRAL ACTIVITY; ARTICLE; BLOOD SAMPLING; CHRONIC HEPATITIS; DRUG EFFECT; DRUG EFFICACY; FATIGUE; FEMALE; HEADACHE; HEPATITIS B; HUMAN; LIVER BIOPSY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; SIDE EFFECT; VIRAL BREAKTHROUGH; VIRUS DETECTION; VIRUS MUTANT;

EID: 19944426352     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2004.03464.x     Document Type: Article

References (19)

1. Dienstag JL, Perrillo RP, Schiff ER, Bartholomew M, Vicary C, Rubin M. A preliminary trial of lamivudine for chronic hepatitis B infection. N. Engl. J. Med. 1995; 333: 1657-61.
2. Dienstag JL, Schiff ER, Wright TL et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N. Engl. J. Med. 1999; 341: 1256-63.
3. Nowak MA, Bonhoeffer S, Hill AM, Boehme R, Thomas HC, McDade H. Viral dynamics in hepatitis B virus infection. Proc. Natl Acad. Sci. USA 1996; 93: 4398-402.
4. Zeuzem S, de Man RA, Honkoop P, Roth WK, Schalm SW, Schmidt JM. Dynamics of hepatitis B virus infection in vivo. J. Hepatol. 1997; 27: 431-6.
5. Di Bisceglie AM. Combination therapy for hepatitis B. Gut 2002; 50: 443-5.
6. Kaplan DD, Reddy KR. One two tandem of lamivudine and interferon might work for patients with chronic hepatitis B who failed interferon monotherapy. Am. J. Gastroenterol. 2002; 97: 2465-7.
7. Mutimer D, Naoumov N, Honkoop P et al. Combination alpha-interferon and lamivudine therapy for alpha-interferon-resistant chronic hepatitis B infection: results of a pilot study. J. Hepatol. 1998; 28: 923-9.
8. Schalm SW, Heathcote J, Cianciara J et al. Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial. Gut 2000; 46: 562-8.
9. Ishak K, Baptista A, Bianchi L et al. Histological grading and staging of chronic hepatitis. J. Hepatol. 1995; 22: 696-9.
10. Chung YH, Song BC, Lee GC et al. Individualization of interferon therapy using hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: a randomized controlled study. Eur. J. Gastroenterol. Hepatol. 2003; 15: 489-93.
11. Baker BL, Di Bisceglie AM, Kaneko S et al. Determination of hepatitis B virus DNA in serum using the polymerase chain reaction: clinical significance and correlation with serological and biochemical markers. Hepatology 1991; 13: 632-6.
12. Kaneko S, Miller RH, Di Bisceglie AM, Feinstone SM, Hoofnagle JH, Purcell RH. Detection of hepatitis B virus DNA in serum by polymerase chain reaction: application for clinical diagnosis. Gastroenterology 1990; 99: 799-804.
13. Ryu SH, Chung YH, Choi MH et al. Long-term additional lamivudine therapy enhances durability of lamivudine-induced HBeAg loss: a prospective study. J. Hepatol. 2003; 39: 614-19.
14. Rang A, Gunther S, Will H. Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells. J. Hepatol. 1999; 31: 791-9.
15. Guptan RC, Thakur V, Kazim SN, Sarin SK. Efficacy of granulocyte- macrophage colony-stimulating factor or lamivudine combination with recombinant interferon in non-responders to interferon in hepatitis B virus-related chronic liver disease patients. J. Gastroenterol. Hepatol. 2002; 17: 765-71.
16. Tatulli I, Francavilla R, Rizzo GL et al. Lamivudine and alpha-interferon in combination long term for precore mutant chronic hepatitis B. J. Hepatol. 2001; 35: 805-10.
17. Santantonio T, Niro GA, Sinisi E et al. Lamivudine/interferon combination therapy in anti-HBe positive chronic hepatitis B patients: a controlled pilot study. J. Hepatol. 2002; 36: 799-804.
18. Richman DD. The impact of drug resistance on the effectiveness of chemotherapy for chronic hepatitis B. Hepatology 2000; 32: 866-7.
19. Chisari FV. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 1995; 13: 29-60.